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2019

A Dynamic Core in Human NQO1 Controls the Functional and Stability Effects of Ligand Binding and Their Communication across the Enzyme Dimer

Vankova, P., Salido, E., Timson, D., Man, P. & Pey, A. L., 12 Nov 2019, In : Biomolecules. 9, 11, 728.

Research output: Contribution to journalArticle

Open Access
File
Flavin-Adenine Dinucleotide
Dicumarol
Dimers
Ligands
Communication

Cancer-associated variants of human NQO1: Impacts on inhibitor binding and cooperativity

Megarity, C. F. & Timson, D. J., 6 Sep 2019, In : Bioscience Reports. 39, 9, BSR20191874.

Research output: Contribution to journalArticle

Open Access
File
Dicumarol
Niacinamide
Oxidoreductases
Quinine
Enzymes

Catalytic mechanism of mevalonate kinase revisited, a QM/MM study

McClory, J., Lin, J. T., Timson, D., Zhang, J. & Huang, M., 5 Feb 2019, In : Organic and Biomolecular Chemistry. 17, 9, p. 2423-2431 9 p.

Research output: Contribution to journalArticle

Open Access
File
mevalonate kinase
Mevalonic Acid
Adenosine Triphosphate
Biofuels
Phosphorylation

Characterization of Calcium-Binding Proteins from Parasitic Worms

Thomas, C. M. & Timson, D. J., 2 Feb 2019, Calcium-Binding Proteins of the EF-Hand Superfamily. Heizmann, C. (ed.). New York: Humana Press, Vol. 1929. p. 615-641 27 p. (Methods in molecular biology (Clifton, N.J.)).

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapter

Calcium-Binding Proteins
Helminths
Calcium Signaling
Helminth Proteins
Pharmaceutical Preparations

Dynamic origins of substrate promiscuity in bacterial galactokinases

McAuley, M., Huang, M. & Timson, D., 17 Oct 2019, In : Carbohydrate Research. 486, 107839.

Research output: Contribution to journalArticle

Enzymes
Escherichia coli
Galactokinase
Sugar Phosphates
Bacterial Structures
Dicumarol
Eukaryota
Oxidoreductases
Escherichia coli
Alanine

Evidence for chaotropicity/kosmotropicity offset in a yeast growth model

Eardley, J., Dedi, C., Dymond, M., Hallsworth, J. E. & Timson, D., 26 Sep 2019, In : Biotechnology Letters. 41, 11, p. 1309-1318 10 p.

Research output: Contribution to journalArticle

yeast
ethanol
ammonium sulfate
fermentation
solute

Four Challenges for Better Biocatalysts

Timson, D. J., 9 May 2019, In : Fermentation. 5, 2, 9 p., 39.

Research output: Contribution to journalArticle

Open Access
File
Enzymes
Protein folding
Biochemistry
Molecules
Biomolecules

Fructose 1,6-bisphosphatase: getting the message across

Timson, D., 6 Mar 2019, In : Bioscience Reports. 39, 3, p. 1-5 5 p., BSR20190124.

Research output: Contribution to journalArticle

Open Access
File
Fructose-Bisphosphatase
Adenosine Monophosphate
Enzymes
Binding Sites
Allosteric Regulation

Myosin Va and spermine synthase: partners in exosome transport

Timson, D., 30 Apr 2019, In : Bioscience Reports. 39, 4, p. 1-5 5 p., BSR20190326.

Research output: Contribution to journalArticle

Open Access
File
Spermine Synthase
Exosomes
Myosins
Proteins
Genes

NAD(P)H quinone oxidoreductase (NQO1): An enzyme which needs just enough mobility, in just the right places

Pey, A. L., Megarity, C. F. & Timson, D. J., 3 Jan 2019, In : Bioscience Reports. 39, 1, BSR20180459.

Research output: Contribution to journalArticle

Open Access
File
Flavin-Adenine Dinucleotide
NAD
Oxidoreductases
Dicumarol
Quinones

Negative cooperativity in NAD(P)H quinone oxidoreductase 1 (NQO1)

Megarity, C. F., Abdel-Aal Bettley, H., Caraher, M. C., Scott, K. A., Whitehead, R. A., Jowitt, T. A., Gutierrez, A., Bryce, R. A., Nolan, K. A., Stratford, I. J. & Timson, D. J., 5 Jun 2019, In : ChemBioChem. 20, 22, p. 2841-2849 9 p.

Research output: Contribution to journalArticle

NAD
Oxidoreductases
Dicumarol
Binding Sites
Proteins

NQO1: A target for the treatment of cancer and neurological diseases, and a model to understand loss of function disease mechanisms

Beaver, S. K., Mesa-Torres, N., Pey, A. L. & Timson, D. J., 12 May 2019, In : BBA - Proteins and Proteomics. 1867, 7-8, p. 663-676 14 p.

Research output: Contribution to journalReview article

Flavin-Adenine Dinucleotide
NAD
Neoplasms
Proteins
Genetic Suppression

Phosphorylation Mechanism of N-acetyl-L-Glutamate Kinase, a QM/MM Study

McClory, J., Hu, G-X., Zou, J-W., Timson, D. J. & Huang, M., 8 Mar 2019, In : Journal of Physical Chemistry B. 123, 13, p. 2844-2852 9 p.

Research output: Contribution to journalArticle

glutamate 5-kinase
acetylglutamate kinase
phosphorylation
glutamates
Phosphorylation

Repurposing drugs for the treatment of galactosemia

Timson, D., 22 Oct 2019, In : Expert Opinion on Orphan Drugs. 7, 10, p. 443-451 9 p.

Research output: Contribution to journalReview article

Drug Repositioning
Galactosemias
Galactose
Therapeutics
Antioxidants
2018

A galactokinase-like protein from the liver fluke Fasciola hepatica

Zinsser, V. L., Cox, C., McAuley, M., Hoey, E. M., Trudgett, A. & Timson, D. J., 21 Jul 2018, In : Experimental Parasitology. 192, p. 65-72 8 p.

Research output: Contribution to journalArticle

Open Access
File
Galactokinase
Fasciola hepatica
Galactose
Acetylgalactosamine
Proteins
Open Access
File
Schistosoma mansoni
Calmodulin
Calcium Channels
Calcium
Ions

Improving the activity and stability of human galactokinase for therapeutic and biotechnological applications

McAuley, M., Mesa-Torres, N., McFall, A., Morris, S., Huang, M., Pey, A. L. & Timson, D., 26 Apr 2018, In : ChemBioChem. 19, 10, p. 1088-1095 8 p.

Research output: Contribution to journalArticle

Open Access
File
Galactokinase
Human Activities
Enzyme Replacement Therapy
Enzymes
Galactosemias

Modulation of the mobility of a key region in human galactokinase: Impacts on catalysis and stability

McAuley, M., Huang, M. & Timson, D. J., 19 Sep 2018, In : Bioorganic Chemistry. 81, p. 649-657 9 p.

Research output: Contribution to journalArticle

Open Access
File
Galactokinase
Catalysis
Enzymes
Galactose
Catalytic Domain

Natural (and Unnatural) Small Molecules as Pharmacological Chaperones and Inhibitors in Cancer

Betancor-Fernández, I., Timson, D. J., Salido, E. & Pey, A. L., 1 Jan 2018, Targeting Trafficking in Drug Development. Ulloa-Aguirre, A. & Tao, Y. X. (eds.). Springer, p. 155-190 36 p. (Handbook of Experimental Pharmacology; vol. 245).

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapter

Pharmacology
Molecules
Protein Stability
Neoplasms
Proteins

Prenatal alcohol exposure, biomarkers and fetal alcohol spectrum disorders

Gard, P. R., Zanganeh, M. & Timson, D. J., 4 Dec 2018, Fetal Alcohol Syndrome: Recognition, Differential Diagnosis and Long-Term Effects. Nova Science Publishers Inc, p. 19-57 39 p.

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapter

Fetal Alcohol Spectrum Disorders
Biomarkers
Alcohols
Histone Code
Mothers

Prenatal Alcohol Exposure, Biomarkers and Foetal Alcohol Spectrum Disorders

Gard, P., Zanganeh, M. & Timson, D., Nov 2018, Fetal Alcohol Syndrome: Recognition, Differential Diagnosis and Long-Term Effects. Knight, D. (ed.). Nova Science Publishers Inc, p. 19-57 38 p.

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapter

Fetal Alcohol Spectrum Disorders
Biomarkers
Alcohols
Histone Code
Mothers

The mechanism of action of praziquantel: Six hypotheses

Thomas, C. M. & Timson, D. J., 1 Jan 2018, In : Current Topics in Medicinal Chemistry. 18, 18, p. 1575-1584 10 p.

Research output: Contribution to journalReview article

Open Access
File
Praziquantel
Pharmaceutical Preparations
Anthelmintics
Parasites
Hydra

The mechanism of action of praziquantel: can new drugs exploit similar mechanisms?

Thomas, C. & Timson, D., 26 Sep 2018, In : Current Medicinal Chemistry. 25, 1

Research output: Contribution to journalArticle

Open Access
File
Praziquantel
Pharmaceutical Preparations
Calcium Channels
Paralysis
Ions

The tegumental allergen-like proteins of Schistosoma mansoni: a biochemical study of SmTAL4-TAL13

Carson, J., Thomas, C. M., McGinty, A., Takata, G. & Timson, D., 14 Feb 2018, In : Molecular and Biochemical Parasitology. 221, p. 14-22 9 p.

Research output: Contribution to journalArticle

Open Access
File
Schistosoma mansoni
allergens
ions
hands
proteins

Type IV galactosemia

Timson, D. J., 21 Nov 2018, In : Genetics in Medicine. 21, p. 1283-1285

Research output: Contribution to journalArticle

Open Access
File

Water-mediated network in the resistance mechanism of fosfomycin

McClory, J., Lin, J. T., Timson, D. J., Zhang, J. & Huang, M., 2 Aug 2018, In : Physical Chemistry Chemical Physics. 20, 33, p. 21660-21667 8 p.

Research output: Contribution to journalArticle

Open Access
File
Fosfomycin
Water
phosphates
phosphorylation
Phosphorylation
2017

Characterisation of eppin function: expression and activity in the lung

Scott, A., Glasgow, A., Small, D., Carlile, S., McCrudden, M. T. C., McLean, D. T. F., Brown, R., Doherty, D., Lundy, F. T., Hamid, U. I., O'Kane, C. M., McAuley, D. F., Brodlie, M., Tunney, M., Elborn, J. S., Irwin, C. R., Timson, D., Taggart, C. C. & Weldon, S., 13 Jul 2017, In : European Respiratory Journal. 50, 1

Research output: Contribution to journalArticle

Open Access
File
Lipopolysaccharides
Myeloid Cells
Lung
Chemokine CXCL2
Serine Proteinase Inhibitors

Different specificities of two aldehyde dehydrogenases from Saccharomyces cerevisiae var boulardii

Datta, S., Annapore, U. S. & Timson, D., 26 Jan 2017, In : Bioscience Reports. 37, 2

Research output: Contribution to journalArticle

Open Access
File
aldehyde dehydrogenase
aldehydes
Saccharomyces cerevisiae
active sites
isozymes

Enhanced vulnerability of human proteins towards disease-associated inactivation through divergent evolution

Medina-Carmona, E., Fuchs, J. E., Gavira, J. A., Mesa-Torres, N., Neira, J. L., Salido, E., Palomino-Morales, R. J., Burgos, M., Timson, D. & Pey, A. L., 6 Jul 2017, In : Human Molecular Genetics. 26, 18, p. 3531-3544 14 p.

Research output: Contribution to journalArticle

Open Access
File
Proteins
Amino Acids
Mutation
Protein Stability
Genetic Suppression
Open Access
File
Triose-Phosphate Isomerase
Computer Simulation
Mutation
Genes
Amino Acids

LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1 -Rac1 pathway

Carmon, K. S., Xing, G., Yi, J., Wu, L., Thomas, A., Moore, C., Masuho, I., Timson, D., Martemyanov, K. A. & Liu, Q. J., 24 Jul 2017, In : Journal of Biological Chemistry. 292, p. 14989-15001 13 p.

Research output: Contribution to journalArticle

Open Access
File
Cell Adhesion
Colonic Neoplasms
Stem Cells
Actins
Catenins

Molecular Genetics of Galactosaemia

Timson, D., 15 May 2017, eLS. Chichester: John Wiley & Sons Ltd

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapter

Galactosemias
Molecular Biology
Genes
UDPglucose 4-Epimerase
Galactokinase

New model for the interaction of IQGAP1 with CDC42 and RAC1

Nouri, K., Timson, D. & Ahmadian, M. R., 19 Jun 2017, In : Small GTPases.

Research output: Contribution to journalArticle

Open Access
File
Proteins
GTP Phosphohydrolases
Adhesion
Polarization

Reaction Mechanism of Isopentenyl Phosphate Kinase: A QM/MM Study

McClory, J., Timson, D., Singh, W., Zhang, J. & Huang, M., 20 Nov 2017, In : Journal of Physical Chemistry B. 121, 49, p. 11062-11071 10 p.

Research output: Contribution to journalArticle

Open Access
File
Phosphorylation
Phosphotransferases
Phosphates
Substrates
Metal ions

Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism

Medina-Carmona, E., Neira, J. L., Salido, E., Fuchs, J. E., Palomino-Morales, R. J., Timson, D. & Pey, A. L., 14 Mar 2017, In : Scientific Reports. 7

Research output: Contribution to journalArticle

Open Access
File
Flavin-Adenine Dinucleotide
Neoplasms
Inborn Genetic Diseases
Proteins
Prodrugs
Open Access
File
Acetylgalactosamine
Uridine Diphosphate
Galactosamine
Pharmaceutical Preparations
Neoplasms

We are all mutants

Timson, D., 2017, In : School Science Review. 99, 366, p. 45-50

Research output: Contribution to journalArticle

Down Syndrome
science
social science
Disease
cause
2015

Chaotropicity: a key factor in product tolerance of biofuel-producing microorganisms

Cray, J. A., Stevenson, A., Ball, P., Bankar, S. B., Eleutherio, E. C. A., Ezeji, T. C., Singhal, R. S., Thevelein, J. M., Timson, D. & Hallsworth, J. E., 30 Jun 2015, In : Current Opinion in Biotechnology. 33, p. 228-259 32 p.

Research output: Contribution to journalArticle

Comparative biochemical analysis of three members of the Schistosoma mansoni TAL family: Differences in ion and drug binding properties

Thomas, C. M., Fitzsimmons, C. M., Timson, D. & Dunne, D. W., 31 Jan 2015, In : Biochimie. 108, p. 40-47 8 p.

Research output: Contribution to journalArticle

Open Access
File

Dicoumarol: a drug which hits at least two very different targets in vitamin K metabolism

Timson, D., 22 Jul 2015, In : Current Drug Targets. 16, p. 1-11 11 p.

Research output: Contribution to journalArticle

Open Access
File
Dicumarol
Vitamin K
Warfarin
Vitamin K Epoxide Reductases
Pharmaceutical Preparations

FhCaBP2: a Fasciola hepatica calcium-binding protein with EF-hand and dynein light chain domains

Thomas, C. M. & Timson, D., 30 Sep 2015, In : Parasitology. 142, 11, p. 1375-1386 12 p.

Research output: Contribution to journalArticle

Open Access
File

Is there a common water-activity limit for the three domains of life?

Stevenson, A., Cray, J. A., Williams, J. P., Santos, R., Sahay, R., Neuenkirchen, N., McClure, C. D., Grant, I. R., Houghton, J. D. R. & Timson, D., 30 Jun 2015, In : ISME Journal. 9, 6, p. 1333-1351 19 p.

Research output: Contribution to journalArticle

Open Access
File

Multiplication of microbes below 0.690 water activity: implications for terrestrial and extraterrestrial life

Stevenson, A., Burkhardt, J., Cockell, C. S., Cray, J. A., Dijksterhuis, J., Fox-Powell, M., Kee, T. P., Kminek, G., McGenity, T. J. & Timson, D., 28 Feb 2015, In : Environmental Microbiology. 17, 2, p. 257-277 21 p.

Research output: Contribution to journalArticle

Quantitative enzymology

Timson, D. J., 1 Jul 2015, In : Current Enzyme Inhibition. 11, 1, p. 12-31 20 p.

Research output: Contribution to journalArticle

Enzymes
Enzyme kinetics
Biotechnology
Drug Delivery Systems
Therapeutics

The molecular basis of galactosemia — Past, present and future

Timson, D. J., 2 Jul 2015, In : Gene. 589, 2, p. 133-141 9 p.

Research output: Contribution to journalArticle

Galactosemias
Galactose
UDPglucose 4-Epimerase
Oxidative Stress
Inborn Errors Metabolism

UDP-galactose 4 '-epimerase from the liver fluke, Fasciola hepatica: biochemical characterization of the enzyme and identification of inhibitors

Zinsser, V. L., Lindert, S., Banford, S., Hoey, E. M., Trudgett, A. & Timson, D., 31 Mar 2015, In : Parasitology. 142, 3, p. 463-472 10 p.

Research output: Contribution to journalArticle

2014

Biochemical characterisation of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) from the liver fluke, Fasciola hepatica

Zinsser, V. L., Hoey, E. M., Trudgett, A. & Timson, D., 30 Apr 2014, In : BBA - Proteins and Proteomics. 1844, 4, p. 744-749 6 p.

Research output: Contribution to journalArticle

Calcium binding proteins in the liver fluke, Fasciola Hepatica

Russell, S. L. & Timson, D. J., 1 Jan 2014, New Developments in Calcium Signaling Research. Nova Science Publishers Inc, p. 89-103 15 p.

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapter

Fasciola hepatica
Calcium-Binding Proteins
Liver
Calcium
Dyneins