Projects per year
Personal profile
Research interests
My research looks to understand the development, regulation and pathology of the musculoskeletal system, with a particular focus on understanding the molecular pathogenesis of osteoarthritis. My current research is funded by the Medical Research Council (>£2 million). My group consists of PDRAs Drs Lucie Bourne, Aikta Sharma and Lucinda Evans, and PhD students (Natalie Crump, Sophia Khan, Bew Promruk, Mohamed Habbat).
I currently sit on Veterinary Advisory Committee for the Horserace Betting Levy Board, the Scientific Advisory Committee for Orthopaedic Research UK, and the Research Grant Assessment Panel for the Royal Osteoporosis Society. I am on the Editorial Board for the Frontiers in Endocrinology, Bone Research. I regularly review papers for a number of internationally-recoginsed journals, and have reviewed grants for a number of funding bodies including the MRC, BBSRC, & the Rosetrees Trust.. My research has featured as a number of press releases. I am currently the ECR Ambassador for the University of Brighton.
Scholarly biography
I completed my BSc in Anatomical Sciences at Bristol University in 2008. I then moved to the University of Edinburgh and was awarded my PhD in 2012, with a thesis that examined the role of Mepe in chondrocyte matrix mineralisation, under the direction of Prof. Colin Farquharson.
In 2012, I started my first postdoctoral position with Prof. Andy Pitsillides at the Royal Veterinary College, London. It was during this Arthritis Research UK funded post that my interest in osteoarthritis developed. In 2014, Imoved back to the University of Edinburgh to work on another Arthritis Research UK postdoctoral position looking at the subchondral bone in osteoarthritis. I was then awarded a Vice Chancellor's Fellowship at Edinburgh Napier University in 2017, before joining the University of Brighton as a Senior Lecturer in 2020.
Supervisory Interests
I currently supervise a dynamic team of PhD students and postdocs examining musculoskeletal health. My supervisory interests are:
- Osteoarthritis
- Secondary osteoporosis
- Musculoskeletal model development
- Imaging of the musculoskeletal system
I am always happy to hear from enthusiastic and motivated individuals who are looking to join our team.
Approach to teaching
I teach on various courses within the School of Applied Sciences on the Biomedical and Biological Sciences courses, as well as in Pharmacy. I adopt a research-focused approach to my teaching across all levels, including discussing current and exciting literature, as well as my own research and that within SAS. I always strive to make my teaching as interactive as possible and particularly enjoy welcoming final year UG students and Masters level students to my lab for their research projects.
Education/Academic qualification
PhD, The role of Mepe in chondrocyte matrix mineralisation, University of Edinburgh
2008 → 2012
Bachelor, Anatomical Sciences, University of Bristol
2005 → 2008
Keywords
- QM Human anatomy
- Bone
- Cartilage
- Joints
- Growth plate
- QP Physiology
- Osteoarthritis
- Osteoporosis
- Chronic Kidney Disease
- Biomineralisation
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- 6 Similar Profiles
Collaborations and top research areas from the last five years
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Understanding the heterogeneity of diseased tissue using state of the art omics technology for the prevention and treatment of disease
Yeoman, M. (PI), Patel, B. (CoI), Flint, M. (CoI), Staines, K. (CoI), Faragher, R. (CoI), Dymond, M. (CoI), Stewart, N. (CoI), Santin, M. (CoI), Shakur, R. (CoI), Mullen, L. (CoI), Waddell, S. (CoI) & Hafezparast, M. (CoI)
1/10/23 → 31/03/26
Project: Research Councils / Government Depts.
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BioGrOA: Imaging joint biomechanics in growth and osteoarthritis
Staines, K. (PI)
1/03/22 → 30/09/25
Project: Research Councils / Government Depts.
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Osteoarthritis: Going back to basics
Staines, K. (PI)
4/09/18 → 3/09/21
Project: Research Councils / Government Depts.
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Mitochondrial dysfunction and mitophagy blockade contribute to renal osteodystrophy in chronic kidney disease-mineral bone disorder
Staines, K., 16 Jan 2025, (Accepted/In press) In: Kidney International. 52 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Associations between life course longitudinal growth and hip shapes at ages 60–64 years: evidence from the MRC National Survey of Health and Development
Staines, K. A., Saunders, F. R., Ireland, A., Aspden, R. M., Gregory, J. S., Hardy, R. J. & Cooper, R., 10 Apr 2024, In: RMD Open. 10, 2, e003816.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Sexually dimorphic effects of prenatal alcohol exposure on the murine skeleton
Bourne, L. E., Jayash, S. N., Michels, L. V., Hopkinson, M., Guppy, F. M., Clarkin, C. E., Gard, P., Brissett, N. & Staines, K. A., 18 Jun 2024, In: Biology of Sex Differences. 15, 1, 19 p., 51.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
The effects of physiological and injurious hydrostatic pressure on murine ex vivo articular and growth plate cartilage explants: an RNAseq study
Bourne, L., Hesketh, A., Sharma, A., Bucca, G., Bush, P. & Staines, K., 7 Dec 2023, In: Frontiers in Endocrinology. 14Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Ciliary IFT88 protects coordinated adolescent growth plate ossification from disruptive physiological mechanical forces
Coveney, C. R., Samvelyan, H. J., Miotla-Zarebska, J., Carnegie, J., Chang, E., Corrin, C. J., Coveney, T., Stott, B., Parisi, I., Duarte, C., Vincent, T. L., Staines, K. & Wann, A. K. T., 17 Jan 2022, In: Journal of Bone and Mineral Research. 37, 6, p. 1081-1096 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile
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Growth plate fusion mechanisms”
Staines, K. (Presenter)
2023Activity: External talk or presentation › Invited talk
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Growth plate biology
Staines, K. (Presenter)
2023Activity: External talk or presentation › Invited talk
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Mechanisms of growth plate fusion
Staines, K. (Presenter)
2023Activity: External talk or presentation › Invited talk
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Growth plate bridging
Staines, K. (Presenter)
2022Activity: External talk or presentation › Invited talk
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Do growth plate fusion mechanisms underpin lifelong MSK health?
Staines, K. (Presenter)
2022Activity: External talk or presentation › Invited talk