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Personal profile

Research interests

My research looks to understand the development, regulation and pathology of the musculoskeletal system, with a particular focus on understanding the molecular pathogenesis of osteoarthritis. My current research is funded by the Medical Research Council & Medical Research Scotland, and my group consists of a PDRA (Dr Jasmine Samvelyan), and three PhD students (David Hughes, Rachel Lopera-Burgueno, Lewis Hsu).

 

I am in the European Calcified Tissue Society (ECTS) Academy, and currently sit on the Editorial Board for the Journal of Endocrinology, the Journal of Molecular Endocrinology, BMC musculoskeletal disorders, and Frontiers in Endocrinology, Bone Research. I has reviewed papers for more than 305 different internationally-recoginsed journals, and has reviewed grants for a number of funding bodies including the Rosetrees Trust, the ECTS, and the Belgian Public Research Programme. My research has featured as a number of press releases.

Scholarly biography

I completed my BSc in Anatomical Sciences at Bristol University in 2008. I then moved to the University of Edinburgh and was awarded my PhD in 2012, with a thesis that examined the role of Mepe in chondrocyte matrix mineralisation, under the direction of Prof. Colin Farquharson.

In 2012, I started my first postdoctoral position with Prof. Andy Pitsillides at the Royal Veterinary College, London. It was during this Arthritis Research UK funded post that my interest in osteoarthritis developed. In 2014, Imoved back to the University of Edinburgh to work on another Arthritis Research UK postdoctoral position looking at the subchondral bone in osteoarthritis. I was then awarded a Vice Chancellor's Fellowship at Edinburgh Napier University in 2017, before joining the University of Brighton as a Senior Lecturer in 2020.

Education/Academic qualification

PhD, University of Edinburgh

20082012

Bachelor, University of Bristol

20052008

Fingerprint Dive into the research topics where Katherine Staines is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Azathioprine Medicine & Life Sciences
Inflammatory Bowel Diseases Medicine & Life Sciences
Osteocytes Medicine & Life Sciences
Bone and Bones Medicine & Life Sciences
Autophagy Medicine & Life Sciences
Bone Chemical Compounds
X Ray Tomography Medicine & Life Sciences
Unfolded Protein Response Medicine & Life Sciences

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Research Output 2011 2020

Conditional deletion of E11/Podoplanin in bone protects against ovariectomy-induced increases in osteoclast formation and activity

Staines, KA., Hopkinson, M., Dillon, S., Stephen, LA., Fleming, R., Sophocleous, A., Buttle, DJ., Pitsillides, AA. & Farquharson, C., 2 Jan 2020, In : Bioscience Reports. 40, 1, BSR20190329.

Research output: Contribution to journalArticle

Open Access
File
Ovariectomy
Osteoclasts
Osteocytes
Bone
Knockout Mice

Azathioprine Has a Deleterious Effect on the Bone Health of Mice with DSS-Induced Inflammatory Bowel Disease

Morgan, S., Hooper, KM., Milne, EM., Farquharson, C., Stevens, C. & Staines, KA., 3 Dec 2019, In : International Journal of Molecular Sciences. 20, 23, 6085.

Research output: Contribution to journalArticle

Open Access
File
Dextran Sulfate
dextrans
Sodium sulfate
Dextran
Azathioprine

Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis

Staines, KA., Ikpegbu, E., Törnqvist, AE., Dillon, S., Javaheri, B., Amin, AK., Clements, DN., Buttle, DJ., Pitsillides, AA. & Farquharson, C., 27 Jul 2019, In : BMC Musculoskeletal Disorders. 20, 344.

Research output: Contribution to journalArticle

Open Access
File

How To Build a Bone: PHOSPHO1, Biomineralization, and Beyond

Dillon, S., Staines, K. A., Millán, J. L. & Farquharson, C., 10 May 2019, In : JBMR Plus. 3, 7, e10202.

Research output: Contribution to journalArticle

Open Access
File

In situ characterization of nanoscale strains in loaded whole joints via synchrotron X-ray tomography

Madi, K., Staines, KA., Bay, BK., Javaheri, B., Geng, H., Bodey, AJ., Cartmell, S., Pitsillides, AA. & Lee, PD., 25 Nov 2019, In : Nature biomedical engineering.

Research output: Contribution to journalArticle

X Ray Tomography
Synchrotrons
Tomography
Joints
Tissue