Photo of Matteo Santin

Matteo Santin

Prof

  • Lewes Road, Huxley

    BN2 4GJ Brighton

    United Kingdom

19992019
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Personal profile

Research interests

Professor Santin's research interests are in the field of Regenerative Medicine.

He has been involved in many research projects with a focus ranging from bone and cartilage regeneration, cardiovascular devices, control of angiogenesis in cartilage regeneration and ischaemia and neurodegenerative diseases. Prof Santin's multidisciplinary research group has been developing natural biomaterials (for example, soybean-based biomaterials) and synthetic biomimetic nano-structured biomaterials (such as, hyperbranched polymers) able to control tissue regeneration as well as establishing in vitroclinically-reflective models for the testing of biomaterials, drugs and tissue engineering constructs.

Scholarly biography

Professor Matteo Santin is the leader of the Centre for Regenerative Medicine and Devices. He is also academic lead for Healthy Futures, one of five themes for cross-cutting research and enterprise across the University.

Professor Santin has over 25 years’ experience in the field of Biomaterials for Medical Devices and Tissue Engineering for a wide range of clinical applications. He has founded two start-up companies, Tissue Click Ltd. and Brighton Wound Care Ltd.

Professor Santin is the President of the European Society for Biomaterials (2013-2017), Emeritus Editor of the Journal of Materials Science: Materials in Medicine, Springer Nature Publishing Group and member of several scientific boards of research organisations and charities.

"My career in biomedical research and teaching spans over 25 years and it has been marked by significant achievements that were internationally recognised in 2005 by the European Society for Biomaterials who conferred on me the prestigious Jean Leary Award. My research started as an undergraduate and postgraduate student at the University of Naples (1987-1990) in the field of mammals thermogenesis. Later (1990-1992), I was involved in research projects focusing on protein biochemistry and enzymology in marine organisms and thermophilic bacteria at the Institute of Protein Biochemistry and Enzymology (IBPE), CNR in Naples, Italy. I started working in the field of biomaterials for medical devices and tissue regeneration in 1992 at IBPE. In the same year, I was a visiting scientist at the Institute of Materials Science, University of Connecticut in the USA, developing biomaterials for soft connective tissue regeneration. From 1994 to 1996, I was supported by an EC fellowship for Human Mobility (now knows as the Marie Slodowska-Curie fellowship) at the University of Brighton where I also achieved my PhD in Biomaterials Science. In 1996, I moved to the University of Turin, Italy where I achieved another PhD in Biomaterials. I moved back to the University of Brighton in October 1998 as research fellow in an EC-funded project on bone implants. In 2003, I became Senior Lecturer at the University of Brighton and in 2005 I received the title of Reader in Tissue Regeneration. In 2010, I was granted the title of Professor of Tissue Regeneration.

"In 2013, the University of Brighton gave me the mandate to establish the Centre for Regenerative Medicine and Devices, a multi-disciplinary centre including over 30 members of the staff across the University campuses and a number of early career researchers and postgraduate students. In 2017, I was appointed as academic lead for Healthy Futures, one of five themes for cross-cutting research and enterprise across the University.

"From 2008 to 2015, I was the Associate Editor (2008-2014) and Editor-in-Chief (2014-2015) of the Journal of Materials Science: Materials in Medicine, the official journal of the European Society for Biomaterials. Currently, I have the title of Emeritus Editor for this journal.

"In 2009, I was elected as a member of the Council of the European Society for Biomaterials and re-elected for another mandate in 2013 when the Council bestowed on me the prestigious role of President of the European Society for Biomaterials. I am the vice-chair of the European Technology Platform on Nanomedicine, Regenerative Medicine Working Group and a member of various scientific advisory groups for the European Commission, public and charitable organisations in the UK and across Europe. I am the founder and director of two start-up companies with a mission in biomaterials for biomedical applications and pre-clinical handling of transplantable cells – Brighton Wound Care Ltd and Tissue Click Ltd. Since 2011, the two companies have achieved grants and capital funding exceeding £500,000."

Education/Academic qualification

PhD

PhD

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Projects 2016 2019

Research Output 1999 2018

  • 57 Article
  • 2 Conference contribution with ISSN or ISBN
  • 2 Patent

Dendrimeric Poly(Epsilon-Lysine) Delivery Systems for the Enhanced Permeability of Flurbiprofen across the Blood-Brain Barrier in Alzheimer’s Disease

Al-azzawi, S., Masheta, D., Guildford, A., Phillips, G. & Santin, M. 18 Oct 2018 19, 3224, p. 1-18 18 p.

Research output: Contribution to journalArticle

Open Access
File
Flurbiprofen
Dendrimers
Blood-Brain Barrier
Lysine
Permeability

Gadolinium Tagged Osteoprotegerin-Mimicking Peptide: A Novel Magnetic Resonance Imaging Biospecific Contrast Agent for the Inhibition of Osteoclastogenesis and Osteoclast Activity

Mbundi, L., Meikle, S., Busquets Santacana, R., Dowell, N. G., Cercignani, M. & Santin, M. 2 Jun 2018 8, 6, p. 1-15 15 p.

Research output: Contribution to journalArticle

Open Access
File
Osteoprotegerin
Gadolinium
Osteoclasts
Osteogenesis
Contrast Media

Carboxybetaine-modified succinylated chitosan-based beads encourage pancreaticβ-cells (Min-6) to form islet-like spheroids under in vitro conditions

Perugini, V., Best, M., Kumar, S., Guildford, A., Bone, A., Macfarlane, W., Santin, M. & Phillips, G. 30 Dec 2017 29

Research output: Contribution to journalArticle

Open Access
File
Chitosan
Betaine
Cadherins
Cell Survival
Insulin
Open Access
File
tyrosyl-isoleucyl-glycyl-seryl-arginine
Stem Cell Niche
Laminin
Lysine
Stem Cells

Novel superparamagnetic micro-devices based on magnetised PLGA/PLA microparticles obtained by supercritical fluid emulsion and coating by carboxybetaine-functionalised chitosan allowing the tuneable release of therapeutics

Vincenzo, C., Best, M., Reverchon, E., Maffulli, N., Phillips, G., Santin, M. & Giovanna, D. P. 10 May 2017 106, 8, p. 2097-2105 9 p.

Research output: Contribution to journalArticle

Open Access
File
Supercritical fluids
Chitosan
Emulsions
Fluorescein
Biopolymers