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Personal profile

Research interests

My research interests are in the functional replacement of tissues and organs using nanostructured adsorbent and smart polymer materials which can be modified with bioactive molecules to improve biocompatibility and functional performance. I am interested in better understanding the mechanisms that impact the cell-biomaterial interface and in the development of functional biomaterials for cell guidance, the control of infection, inflammation and oxidative stress. Such materials may be used for example, to improve the removal of inflammatory molecules and bacterial toxins which current limit the efficacy of dialysis for kidney and liver disease, as enterosorbents to slow the progression of liver disease, in the development of a wearable artificial kidney and in the development of corneal and lens replacement strategies for ophthalmic tissue engineering. Working within international networks of academic, clinical and industrial partners, I have led research projects funded by UK NIHR i4i (DART and ADEPT), EU FP7 IAPP (ACROBAT), EU Horizon 2020 (CARBALIVE), British Council GII (NOMAD) and UKRI MRC (MXene for accomodating IOL) funding streams.

Supervisory Interests

Current PhD Students   

Amira Nagy (2018-current) Electrospinning of polymer nanocomposites for drug delivery applications

Wulan Koagouw (2017-2021)Integrative Assessment of Marine Pollution - Impact of Pharmaceuticals on Marine Bivalves

Neda Hedari (2017-2021)The role of senescence in bioartificial liver design

Emma Ward (2017-2021)A new class of two dimensional optoelectronic materials in accommodating intraocular lens design

Dr Vankata Avadhanam (2013 - current)Clinico-radiological study of OOKP lamina and development of a synthetic lamina

Tochukwu Ozulumba (2015 - current)Nanostructured scaffolds for remediation of environmental and biological tissue contaminants

Flavia Bonalumi (2017-2020)Engineering a bioartificial liver prototype using cell loaded macroporous hydrogel scaffolds

Previous PhD Students

Elsie Fok (2013) The development of advanced corneal epithelial stem cell delivery systems for the treatment of corneal epithelial defects 

Yishan Zheng  (2012) Hybrid filtration adsorbent systems for extracorporeal applications 

Education/Academic qualification

PhD, University of Brighton

19961999

Bachelor, Queen Mary University of London

19931996

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Research Output 1997 2018

Amine-Functionalized Electrically Conductive Core–Sheath MEH-PPV:PCL Electrospun Nanofibers for Enhanced Cell–Biomaterial Interactions

Borah, R., Ingavle, G., Sandeman, S., Kumar, A. & Mikhalovsky, S. 14 Aug 2018 4, 9, p. 3327–3346 19 p.

Research output: Contribution to journalArticle

Biocompatible Materials
Nanofibers
Amines
1,6-diaminohexane
Collagen

Bioinspired detoxification of blood: The efficient removal of anthrax toxin protective antigen using an extracorporeal macroporous adsorbent device

Ingavle, G., Baillie, L. W. J., Davies, N., Beaton, N., Zheng, Y., Mikhalovsky, S. & Sandeman, S. 14 May 2018 8

Research output: Contribution to journalArticle

Open Access
File
Equipment and Supplies
Hemoperfusion
Antibodies
Monoclonal Antibodies
Exotoxins

Electrically conductive MEH-PPV: PCL electrospun nanofibres for electrical stimulation of rat PC12 pheochromocytoma cells

Borah, R., Ingavle, G., Sandeman, S., Kumar, A. & Mikhalovsky, S. 9 Jul 2018 18 p.

Research output: Contribution to journalArticle

Nanofibers
PC12 Cells
Pheochromocytoma
Electric Stimulation
Electric Conductivity

MXene Sorbents for Removal of Urea from Dialysate: A Step toward the Wearable Artificial Kidney

Meng, F., Seredych, M., Chen, C., Gura, V., Mikahlovsky, S., Sandeman, S., Ingavle, G., Ozulumba, T., Miao, L., Anasori, B. & Gogotsi, Y. 26 Sep 2018

Research output: Contribution to journalArticle

Dialysis Solutions
Sorbents
Urea
Adsorption
Dialysis

Rapid Adsorption of Proinflammatory Cytokines by Graphene Nanoplatelets and Their Composites for Extracorporeal Detoxification

Zheng, Y., Pescatore, N., Gogotsi, Y., Dyatkin, B., Ingavle, G., Mochalin, V., Ozulumba, T., Mikhalovsky, S. & Sandeman, S. 21 Feb 2018 2018

Research output: Contribution to journalArticle

Open Access
File
Graphite
Adsorption
Cytokines
Hemoperfusion
Sepsis