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Personal profile

Research interests

My research is in the field of biomaterials and tissue engineering with current focus on functional tissue and organ replacement strategies for kidney, liver and eye. I am interested in the replacement of tissues and organs using nanostructured adsorbent and smart polymer materials which can be modified with bioactive molecules to improve biocompatibility and functional performance. I am interested in better understanding the mechanisms that impact the cell-biomaterial interface and in the development of functional biomaterials for cell guidance, the control of infection, inflammation and oxidative stress. Such materials may be used for example, to improve the removal of inflammatory molecules and bacterial toxins which current limit the efficacy of dialysis for kidney and liver disease, as enterosorbents to slow the progression of liver disease, in the development of a wearable artificial kidney and in the development of corneal and lens replacement strategies for ophthalmic tissue engineering. Working within international networks of academic, clinical and industrial partners, I have led research projects funded by UK NIHR i4i (DART and ADEPT), EU FP7 IAPP (ACROBAT), EU Horizon 2020 (CARBALIVE), British Council GII (NOMAD) and UKRI MRC (MXene for accomodating IOL) funding streams.

Supervisory Interests

I supervise students in research areas related to biomedical materials and tissue engineering. I'm particularly interested in cell-biomaterial interactions and in strategies to understand changing tissue dynamics in disease and injury in order to optimise functional tissue repair and replacement.

Current PhD Students   

Grace Cooksley (2019-2022) Optoelectronic nanomaterials to reduce the complications associated with cataract surgery

Wulan Koagouw (2017-2021)Integrative Assessment of Marine Pollution - Impact of Pharmaceuticals on Marine Bivalves

Neda Hedari (2017-2021)The role of senescence in bioartificial liver design

Emma Ward (2017-2021)A new class of two dimensional optoelectronic materials in accommodating intraocular lens design

Dr Vankata Avadhanam (2013 - current)Clinico-radiological study of OOKP lamina and development of a synthetic lamina

Tochukwu Ozulumba (2015 - current)Nanostructured scaffolds for remediation of environmental and biological tissue contaminants

Flavia Bonalumi (2017-2020)Engineering a bioartificial liver prototype using cell loaded macroporous hydrogel scaffolds

Previous PhD Students

Elsie Fok (2013) The development of advanced corneal epithelial stem cell delivery systems for the treatment of corneal epithelial defects 

Yishan Zheng  (2012) Hybrid filtration adsorbent systems for extracorporeal applications 

Education/Academic qualification

PhD, University of Brighton

19961999

Bachelor, Queen Mary University of London

19931996

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Projects 2015 2021

Research Output 1997 2019

Green synthesis of Pluronic stabilized reduced graphene oxide: Chemical and biological characterization

Cherian, R., Sandeman, S., Ray, S., Savina, I., Ashtami, J. & Mohanan, PV., 25 Mar 2019, In : Colloids and Surfaces B: Biointerfaces. 179, 19, p. 94-106 13 p.

Research output: Contribution to journalArticle

Poloxamer
Graphite
Oxides
Toxicity
Poisons

Plackett-Burman design for screening of critical variables and their effects on the optical transparency and swelling of gatifloxacin-Pluronic-loaded contact lens

Maulvi, F. A., Parmar, R., Shukla, M., Desai, A., Desai, D., Ranch, K., Shah, S., Sandeman, S. & Shah, D., 5 Jun 2019, In : International Journal of Pharmaceutics. 566, p. 513-519 7 p.

Research output: Contribution to journalArticle

Poloxamer
Contact Lenses
Product Packaging
Micelles
Lenses

Amine-Functionalized Electrically Conductive Core–Sheath MEH-PPV:PCL Electrospun Nanofibers for Enhanced Cell–Biomaterial Interactions

Borah, R., Ingavle, G., Sandeman, S., Kumar, A. & Mikhalovsky, S., 14 Aug 2018, In : ACS Biomaterials Science & Engineering. 4, 9, p. 3327–3346 19 p.

Research output: Contribution to journalArticle

Open Access
File
Nanofibers
Amines
1,6-diaminohexane
Collagen
Scaffolds (biology)

Bioinspired detoxification of blood: The efficient removal of anthrax toxin protective antigen using an extracorporeal macroporous adsorbent device

Ingavle, G., Baillie, L. W. J., Davies, N., Beaton, N., Zheng, Y., Mikhalovsky, S. & Sandeman, S., 14 May 2018, In : Scientific Reports. 8

Research output: Contribution to journalArticle

Open Access
File
Equipment and Supplies
Hemoperfusion
Antibodies
Monoclonal Antibodies
Exotoxins

Electrically conductive MEH-PPV: PCL electrospun nanofibres for electrical stimulation of rat PC12 pheochromocytoma cells

Borah, R., Ingavle, G., Sandeman, S., Kumar, A. & Mikhalovsky, S., 9 Jul 2018, In : Biomaterials Science. 18 p.

Research output: Contribution to journalArticle

Open Access
File
Nanofibers
PC12 Cells
Pheochromocytoma
Electric Stimulation
Electric Conductivity