Projects per year
Personal profile
Research interests
My research is in biomaterials and tissue engineering with current focus on functional tissue and organ replacement strategies. I am interested in the replacement of tissues and organs using nanostructured adsorbent and smart polymer materials which can be modified with bioactive molecules to improve biocompatibility and functional performance. I am interested in better understanding the mechanisms that impact the cell-biomaterial interface and in the development of functional biomaterials for cell guidance, the control of infection, inflammation, and oxidative stress. Such materials may be used for example, to improve the removal of inflammatory molecules and bacterial toxins which current limit the efficacy of dialysis for kidney and liver disease, as enterosorbents to slow the progression of liver disease, in the development of a wearable artificial kidney and in the development of corneal and lens replacement strategies for ophthalmic tissue engineering. Working within international networks of academic, clinical, and industrial partners, I have led research projects funded by UK NIHR i4i (DART and ADEPT), EU FP7 IAPP (ACROBAT), EU Horizon 2020 (CARBALIVE), British Council GII (NOMAD) and UKRI MRC (MXene for accommodating IOL) funding streams. I am a co-inventor on biomedical materials patents linked to this grant activity.
I have served on grant review panels including as a member of the British Council Newton fund Biological and Medical Sciences panel (2014-) and as a peer reviewer for EU Horizon 2020, UKRI MRC, BBSRC and NIHR i4i funding programmes. I am an editor for Scientific Reports, the Journal of Biomaterials and Tissue Engineering and BioMed Research International.
Supervisory Interests
I supervise students in research areas related to biomedical materials and tissue engineering. I'm particularly interested in cell-biomaterial interactions and in strategies to understand changing tissue dynamics in disease and injury in order to optimise functional tissue repair and replacement.
Current PhD Students
Sertan Kiziloz (2023 -). Optimising the wound dressing interface.
Previous PhD Students
Natalia Noriega (2019-2023) Optoelectronic bionanomaterials for ophthalmic biosensing
Grace Cooksley (2019-2022) Optoelectronic nanomaterials to reduce the complications associated with cataract surgery
Neda Hedari (2017-2021)The role of senescence in bioartificial liver design
Emma Ward (2017-2021)A new class of two dimensional optoelectronic materials in accommodating intraocular lens design
Wulan Koagouw (2017-2021)Integrative Assessment of Marine Pollution - Impact of Pharmaceuticals on Marine Bivalves
Flavia Bonalumi (2017-2020)Engineering a bioartificial liver prototype using cell loaded macroporous hydrogel scaffolds
Tochukwu Ozulumba (2015 - 2019)Nanostructured scaffolds for remediation of environmental and biological tissue contaminants
Elsie Fok (2013) The development of advanced corneal epithelial stem cell delivery systems for the treatment of corneal epithelial defects
Yishan Zheng (2012) Hybrid filtration adsorbent systems for extracorporeal applications
Scholarly biography
Dr Susan Sandeman is a Reader in Biomaterials with a research focus on understanding and improving the physiological interaction of materials used in devices to treat organ failure.
After finishing her undergraduate studies at Queen Mary, University of London, Dr Sandeman went on to complete a PhD at the University of Brighton in ophthalmic biomaterials and tissue engineering. Her research identified senescence associated changes in the wound healing response to scaffold materials for use in corneal tissue replacement. Through a number of post-doctoral research positions Dr Sandeman developed an interest in porous hydrogel and synthetic carbon based adsorbents for medical device applications.
Dr Sandeman became a Principal Research Fellow in 2011, Reader in 2015 and Professor in 2024 in addition to her role as Deputy and then Director of Postgraduate Studies. She has been principal investigator on grants totalling more than £2 million from NIHR, EU FP7, British council and MRC funding sources, in addition to industrial and Horizon 2020 funding sources. She leads a research group of PDRAs and PhD students investigating the biological interaction of nanomaterials and smart polymer scaffolds for functional organ replacement.
Approach to teaching
Dr Sandeman teaches topics related to biomedical physiology, biomaterials, tissue engineering and medical device technologies. She aims to equip students with tools that promote both conceptual understanding and critical thought, linking foundational learning to its application in current research innovation.
Dr Sandeman is an advocate for the pivotal role of postgraduate research students in scientific innovation and the need for ambitious international, interdisciplinary, industry linked training programmes to better facilitate innovation across disciplinary boundaries.
Education/Academic qualification
PhD, Factors affecting keratocyte colonisation of novel keratoprosthetic biomaterials, University of Brighton
1996 → 1999
Award Date: 1 Feb 1999
External positions
Expert reviewer
2020 → …
Keywords
- Q Science (General)
- Biomaterials
- tissue engineering
- wound healing
- inflammation
- medical devices
- artificial organs
- host response biology
- biointerface
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Collaborations and top research areas from the last five years
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A biomimetic macromolecular platform for tissue healing and diagnostics at medical device interfaces: a personalised wound dressing model
Santin, M. (PI), Georgoulas, A. (CoI), Harris, P. (CoI), Crua, C. (CoI), Sarker, D. (CoI), Elsom, J. (CoI), Sandeman, S. (CoI), Forss, R. (CoI), Redhead, L. (CoI), Terrazzini, N. (CoI), Saberianpour, S. (PI), Melotto, G. (PI), Hesketh, A. (PI) & Sinha, A. (PI)
1/06/22 → 31/03/28
Project: Research Councils / Government Depts.
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Bioengineering controlled release from contact lens hydrogels
Lloyd, A. (PI), Sandeman, S. (CoI), Pannala, A. (CoI) & Hawthorne, D. (CoI)
1/07/19 → 29/02/24
Project: Industry
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H2020-MSCA-Individual Fellowship- Dual Function Polymer Materials for Blood Contacting Applications
Sandeman, S. (PI) & Azizova, L. (CoI)
18/09/17 → 17/09/19
Project: Grant
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ADePT: An adsorbent device to promote toxin removal during haemodialysis
Sandeman, S. (PI), Howell, C. (CoI), Zheng, Y. (CoI) & Ingavle, G. (CoI)
1/02/13 → 31/01/15
Project: EU / International
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Clinical, experimental and pathophysiological effects of Yaq-001: a non-absorbable, gut-restricted adsorbent in models and patients with cirrhosis
Liu, J., Jane, M., Kerbert, A., Portlock, T., Gonzalez, J., Jin, Y., Clasen, F., Habtesion, A., Ji, H., Jin, Q., Phillips, A., Chiara, F., Ingavle, G., Jimenez, C., Zaccherini, G., Husi, K., Gandia, M., Cordero, P., Soeda, J. & McConaghy, L. & 32 others, , 15 Apr 2024, In: GUT. p. 1-16 16 p., 330699.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
MXenes in Healthcare Technologies
Noriega Pedraza, N., Ozulumba, T., Cooksley, G., Ward, E. & Sandeman, S., 7 Jun 2024, Transition Metal Carbides and Nitrides (MXenes) Handbook: Synthesis, Processing, Properties and Applications. Zhang, C. & Naguib, M. (eds.). Hoboken, New Jersey: Wiley, p. 706-733 28 p.Research output: Chapter in Book/Conference proceeding with ISSN or ISBN › Chapter › peer-review
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Pristine Ti3C2Tx MXene Enables Flexible and Transparent Electrochemical Sensors
Noriega Pedraza, N., Shekhirev, M., Shuck, C., Salvage, J., VahidMohammadi, A., Dymond, M., Lacey, J., Sandeman, S., Gogotsi, Y. & Patel, B., 23 Jan 2024, In: ACS Applied Materials and Interfaces. 16, 5, p. 6569-6578 10 p.Research output: Contribution to journal › Article › peer-review
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Resveralogues protect HepG2 cells against cellular senescence induced by hepatotoxic metabolites
Heidari, N., Sandeman, S., Dymond, M., Rogers, C., Ostler, E. & Faragher, R., 12 May 2024, In: Mechanisms of Ageing and Development. 219, p. 1-12 12 p., 111938.Research output: Contribution to journal › Article › peer-review
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Development of theranostic wound dressings: harnessing the knowledge of biospecific interactions at the biomaterial interface to promote healing and identify biomarkers
Melotto, G., Forss, R., Redhead, L., Elsom, J., Terrazzini, N., Sandeman, S., Sarker, D., Bucca, G., Hesketh, A., Crua, C. & Santin, M., 23 Feb 2023, In: Expert Review of Medical Devices. 20, 3, p. 163-165 3 p.Research output: Contribution to journal › Editorial › peer-review
Open AccessFile
Activities
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Ti3C2Tx MXene in ophthalmic medical device interventions
Sandeman, S. (Invited presenter)
27 Jun 2023 → 30 Jun 2023Activity: External talk or presentation › Invited talk
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Novel materials for intraocular devices
Sandeman, S. (Invited presenter)
4 Apr 2023Activity: External talk or presentation › Invited talk
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NIHR Invention for Innovation (i4i) FAST expert assessor
Sandeman, S. (Member of expert group)
Jan 2023Activity: External funding peer-review
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Building Links in Ageing Science and Translation (BLAST) Network (External organisation)
Sandeman, S. (Member)
2023 → …Activity: External boards and professional/academic bodies › Personal board membership of professional/academic bodies