Development of theranostic wound dressings: harnessing the knowledge of biospecific interactions at the biomaterial interface to promote healing and identify biomarkers

Gianluca Melotto; Rachel Forss; Lucy Redhead; Jacqueline Elsom; Nadia Terrazzini; Susan Sandeman; Dipak Sarker; Giselda Bucca; Andrew Hesketh; Cyril Crua; Matteo Santin

doi:10.1080/17434440.2023.2181694

Development of theranostic wound dressings: harnessing the knowledge of biospecific interactions at the biomaterial interface to promote healing and identify biomarkers

Gianluca Melotto, Rachel Forss, Lucy Redhead, Jacqueline Elsom, Nadia Terrazzini, Susan Sandeman, Dipak Sarker, Giselda Bucca, Andrew Hesketh, Cyril Crua, Matteo Santin

Research output: Contribution to journal › Editorial › peer-review

Original language	English
Pages (from-to)	163-165
Number of pages	3
Journal	Expert Review of Medical Devices
Volume	20
Issue number	3
DOIs	https://doi.org/10.1080/17434440.2023.2181694
Publication status	Published - 23 Feb 2023

Bibliographical note

Funding Information:
This paper is supported by the UKRI Engineering and Physical Science Research Council, grant number EP/W023164/1.

Funding Information:
Although of high interest, these findings have not been linked to the well-established principles of biomaterial biocompatibility that demonstrate that biomaterial surface properties can lead to the adsorption of a wider range of proteins. These proteins play a role either in the cellular biochemical signaling pathways (i.e. pro-inflammatory cytokines and growth factors) or as structural components of the extracellular matrix of tissues (e.g. fibronectin and laminin). Depending on the hydrophobic and electrostatic interactions and hydrogen bonds occurring upon adsorption on polymeric surface, these proteins may either retain their native conformation or undergo denaturation. In the former case, they maintain their biochemical role either in cell signaling or as substrates. In the latter case, they are likely to become antigens capable of activating immune cells, thus protracting the inflammatory response into a chronic status []. In the case of the biomaterials used for manufacturing the absorbent layer of wound dressings, the absorption throughout the mesh of the hydrogels can lead to an additional phenomenon that is the concentration of either favorable or unfavorable proteins and cells within the wound bed. It is therefore argued that a systematic study of the interactions between the biochemical and cellular components of the exudate and the wound dressing biomaterials could indeed drive the development of theranostic wound dressings. It is suggested that these developments could focus on the surface functionalisation of the currently used biomaterials rather than searching for completely new solutions. This is the approach that the authors will be following at the Center for Regenerative Medicine and Devices (CRMD), University of Brighton through a 6-year research project supported by the UK Research and Innovation, Engineering and Physical Science Research Council (EPSRC).

Keywords

Chronic wounds
wound dressings
theranostics
biomimetic biomaterials
healing biomarkers

Access to Document

10.1080/17434440.2023.2181694

Saberianpour et al Exp Rev Med Dev November 2022_Submitted_RevisedAccepted author manuscript, 256 KBLicence: CC BY-NC-ND

Cite this

Melotto, G., Forss, R., Redhead, L., Elsom, J., Terrazzini, N., Sandeman, S., Sarker, D., Bucca, G., Hesketh, A., Crua, C., & Santin, M. (2023). Development of theranostic wound dressings: harnessing the knowledge of biospecific interactions at the biomaterial interface to promote healing and identify biomarkers. Expert Review of Medical Devices, 20(3), 163-165. https://doi.org/10.1080/17434440.2023.2181694

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title = "Development of theranostic wound dressings: harnessing the knowledge of biospecific interactions at the biomaterial interface to promote healing and identify biomarkers",

keywords = "Chronic wounds, wound dressings, theranostics, biomimetic biomaterials, healing biomarkers",

author = "Gianluca Melotto and Rachel Forss and Lucy Redhead and Jacqueline Elsom and Nadia Terrazzini and Susan Sandeman and Dipak Sarker and Giselda Bucca and Andrew Hesketh and Cyril Crua and Matteo Santin",

note = "Funding Information: This paper is supported by the UKRI Engineering and Physical Science Research Council, grant number EP/W023164/1. Funding Information: Although of high interest, these findings have not been linked to the well-established principles of biomaterial biocompatibility that demonstrate that biomaterial surface properties can lead to the adsorption of a wider range of proteins. These proteins play a role either in the cellular biochemical signaling pathways (i.e. pro-inflammatory cytokines and growth factors) or as structural components of the extracellular matrix of tissues (e.g. fibronectin and laminin). Depending on the hydrophobic and electrostatic interactions and hydrogen bonds occurring upon adsorption on polymeric surface, these proteins may either retain their native conformation or undergo denaturation. In the former case, they maintain their biochemical role either in cell signaling or as substrates. In the latter case, they are likely to become antigens capable of activating immune cells, thus protracting the inflammatory response into a chronic status []. In the case of the biomaterials used for manufacturing the absorbent layer of wound dressings, the absorption throughout the mesh of the hydrogels can lead to an additional phenomenon that is the concentration of either favorable or unfavorable proteins and cells within the wound bed. It is therefore argued that a systematic study of the interactions between the biochemical and cellular components of the exudate and the wound dressing biomaterials could indeed drive the development of theranostic wound dressings. It is suggested that these developments could focus on the surface functionalisation of the currently used biomaterials rather than searching for completely new solutions. This is the approach that the authors will be following at the Center for Regenerative Medicine and Devices (CRMD), University of Brighton through a 6-year research project supported by the UK Research and Innovation, Engineering and Physical Science Research Council (EPSRC).",

year = "2023",

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doi = "10.1080/17434440.2023.2181694",

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Melotto, G , Forss, R , Redhead, L, Elsom, J, Terrazzini, N , Sandeman, S , Sarker, D, Bucca, G, Hesketh, A, Crua, C & Santin, M 2023, 'Development of theranostic wound dressings: harnessing the knowledge of biospecific interactions at the biomaterial interface to promote healing and identify biomarkers', Expert Review of Medical Devices, vol. 20, no. 3, pp. 163-165. https://doi.org/10.1080/17434440.2023.2181694

Development of theranostic wound dressings: harnessing the knowledge of biospecific interactions at the biomaterial interface to promote healing and identify biomarkers. / Melotto, Gianluca ; Forss, Rachel ; Redhead, Lucy et al.
In: Expert Review of Medical Devices, Vol. 20, No. 3, 23.02.2023, p. 163-165.

Research output: Contribution to journal › Editorial › peer-review

TY - JOUR

T1 - Development of theranostic wound dressings

T2 - harnessing the knowledge of biospecific interactions at the biomaterial interface to promote healing and identify biomarkers

AU - Melotto, Gianluca

AU - Forss, Rachel

AU - Redhead, Lucy

AU - Elsom, Jacqueline

AU - Terrazzini, Nadia

AU - Sandeman, Susan

AU - Sarker, Dipak

AU - Bucca, Giselda

AU - Hesketh, Andrew

AU - Crua, Cyril

AU - Santin, Matteo

N1 - Funding Information: This paper is supported by the UKRI Engineering and Physical Science Research Council, grant number EP/W023164/1. Funding Information: Although of high interest, these findings have not been linked to the well-established principles of biomaterial biocompatibility that demonstrate that biomaterial surface properties can lead to the adsorption of a wider range of proteins. These proteins play a role either in the cellular biochemical signaling pathways (i.e. pro-inflammatory cytokines and growth factors) or as structural components of the extracellular matrix of tissues (e.g. fibronectin and laminin). Depending on the hydrophobic and electrostatic interactions and hydrogen bonds occurring upon adsorption on polymeric surface, these proteins may either retain their native conformation or undergo denaturation. In the former case, they maintain their biochemical role either in cell signaling or as substrates. In the latter case, they are likely to become antigens capable of activating immune cells, thus protracting the inflammatory response into a chronic status []. In the case of the biomaterials used for manufacturing the absorbent layer of wound dressings, the absorption throughout the mesh of the hydrogels can lead to an additional phenomenon that is the concentration of either favorable or unfavorable proteins and cells within the wound bed. It is therefore argued that a systematic study of the interactions between the biochemical and cellular components of the exudate and the wound dressing biomaterials could indeed drive the development of theranostic wound dressings. It is suggested that these developments could focus on the surface functionalisation of the currently used biomaterials rather than searching for completely new solutions. This is the approach that the authors will be following at the Center for Regenerative Medicine and Devices (CRMD), University of Brighton through a 6-year research project supported by the UK Research and Innovation, Engineering and Physical Science Research Council (EPSRC).

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DO - 10.1080/17434440.2023.2181694

M3 - Editorial

C2 - 36803232

AN - SCOPUS:85149309362

SN - 1743-4440

VL - 20

SP - 163

EP - 165

JO - Expert Review of Medical Devices

JF - Expert Review of Medical Devices

IS - 3

ER -

Development of theranostic wound dressings: harnessing the knowledge of biospecific interactions at the biomaterial interface to promote healing and identify biomarkers

Bibliographical note

Keywords

Access to Document

Other files and links

Climate change chemistry and global warming

Using research interests in sustainable materials and practices to give students a meaningful taste of the pressing sustainability agenda

Materials usage, the circular economy (?) and opportunities of drive change in the orthopaedics sector and wider clinical setting

Cite this

Development of theranostic wound dressings: harnessing the knowledge of biospecific interactions at the biomaterial interface to promote healing and identify biomarkers

Bibliographical note

Keywords

Access to Document

Other files and links

Activities

Climate change chemistry and global warming

Using research interests in sustainable materials and practices to give students a meaningful taste of the pressing sustainability agenda

Materials usage, the circular economy (?) and opportunities of drive change in the orthopaedics sector and wider clinical setting

Cite this