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Personal profile

Research interests

Dr. Flint is a senior Lecturer and cancer research at the University of Brighton. She is currently Co-leader of Brighton and Sussex Cancer Research Network and a member of the Cancer Translation Advisory Group Steering Committee and Theme leader for Cancer. Dr. Flint is also a member of the NCRI Symptom Management Working Group.

 

Dr. Flint trained in the Women’s cancer research center, at the University of Pittsburgh cancer Institute and remains at adjunct Research Assistant Professor in the Department of Pharmacology, University of Pittsburgh.

 

Her work on the effect of stress on cancer progression, chemotherapy and the immune system has been highlighted in the Making Research Matter and will likely results in changing treatment paradigms in patients with cancer.

 

How I like to teach

I currently teach Immunopharmacology, autoimmunity and I’m case leader for Breast Cancer. I prefer a more hands on practical approach to my teaching—this can be achieved though interactive lectures and workshops. Together with psychologist, Macmillan nurses, pharmacologists and pharmacists we will create interactive workshops to enhance student experiences.

 

Quotation  

Its very exciting to work on a (series) of projects that combine the expertise of laboratory based scientists with that of psycho-oncologists in an innovative area of research likely to produce tangible benefits for patients receiving cancer treatments. Valerie Jenkins, SHORE-C Sussex health Outcomes Research and Education group.

Research Interests

Currently, the focus of my laboratory is translational cancer research. Specifically, my research examines hormonal influences on cell cycle regulation and cancer. My primary research project involves the direct interplay between stress hormones (cortisol, noradrenaline) and the immune and cancer cells. This is accomplished through a mechanistic study of administration of stress hormones to cancerous cells, and observing these effects both in vitro, in vivo and human tissue sample models. The goal of my laboratory is to understand the mechanism through which behavioural stress impacts cancer progression.

PI Externally Funded Projects

Team Verrico  'Exploring polymorphisms in breast cancer'  June 2018-2017  £15,000.

CRUK 'A reactive oxygen and nitrogen species (ROS/RNS) monitoring system to study their role in cancer' Role: Co-Principal Investigator   Jan 2018-Jan 2020.

Breast Cancer Research Trust 'Stress hormones in BRCA mutation carriers increase susceptibility to the development of breast cancer' £49,997 Dec 2017-Dec 2018

Scholarly Biography

 I received my Ph.D. at Imperial College, London, UK. I moved to the United States and trained as a postdoctoral scientist at the National Institute of Occupational Safety and Health, Morgantown, WV. It was there that I began a research track in the field of biobehavioral research. I became very interested in the power of stressful influences impacting disease outcome. At the time, I remained focused on the immune and inflammatory systems and the impact of stressful responses. My research interests began to include investigations into how psychosocial hormones influence the immune system and may impact cancer biology. Indeed, I was recruited to join the Behavioral Oncology team at the University of Pittsburgh Cancer Institute (UPCI) as a Research Associate on the basis of my past experience in the field of stress and the immune system. During my tenure in this group, I worked on a number of projects related to how stress may impact the incidence and course of cancer, with a focus on the impact of stress and stress hormones on DNA damage and repair. In 2007, I was promoted to Research Instructor in the Department of Pharmacology & Chemical Biology. I began to apply my molecular and cell biology expertise to complement my breast cancer research, especially with the validation and implementation of cancer biomarkers. I became a Research Assistant Professor in 2012, where I trained in breast and ovarian cancer at the Womens cancer Research center, Pittsburgh. I am currently a Senior lecturer and leader of a stress and breast cancer program at the University of Brighton.

PhD Students

Marta Falcinelli Oct 2016-Oct 2019

Haya Intablis Jan 2016-Dec 2019

Maysa Maysa Al-Natsheh Jan 2017-Jan 2020

Post Doctoral Scientists (as of 2018)

Dr Aya Abdullah

Dr Renee Flaherty

Dr Caroline Garrett

Dr Will Jones

 

 

 

 

 

 

External positions

Adjunct Research Assistant Professor, University of Pittsburgh

1 Jan 2013 → …

Keywords

  • RC0254 Neoplasms. Tumors. Oncology (including Cancer)
  • stress, glucocorticoids, immune, drug resistance

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 3 Similar Profiles
Breast Neoplasms Medicine & Life Sciences
DNA Damage Medicine & Life Sciences
Psychological Stress Medicine & Life Sciences
Hydrocortisone Medicine & Life Sciences
Nitric Oxide Synthase Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Hormones Medicine & Life Sciences
Annexin A6 Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2017 2019

Research Output 1998 2017

Glucocorticoids induce ROS/RNS production and DNA damage through an iNOS mediated pathway in breast cancer

Flaherty, R. L., Owen, M., Fagan-Murphy, A., Intabli, H., Healy, D., Patel, A., Allen, M., Patel, B. & Flint, M. 24 Mar 2017 19

Research output: Contribution to journalArticle

Open Access
File
Glucocorticoids
DNA Damage
Hydrocortisone
Breast Neoplasms
Hormones

Inhibition of nitric oxide synthase (NOS) reduces the effect of stress hormone signalling in breast cancer

Flaherty, R. L., Patel, B., Allen, M. & Flint, M. 11 Sep 2017 p. 6-6 1 p.

Research output: Contribution to conferenceAbstract

Open Access
File
Nitric Oxide Synthase
NG-Nitroarginine Methyl Ester
Hormones
Breast Neoplasms
Nitric Oxide

The role of psychological stress and nitric oxide synthase inhibition in breast cancer

Flaherty, R. L., Patel, B., Allen, M. & Flint, M. 27 Oct 2017 p. 0-0 1 p.

Research output: Contribution to conferenceAbstract

Open Access
File
Psychological Stress
Nitric Oxide Synthase
Breast Neoplasms
Glucocorticoid Receptors
DNA Damage

The TNF-α antagonist etanercept reverses age-related decreases in colonic SERT expression and faecal output in mice

Patel, B., Fidalgo, S., Wang, C., Parmar, L., Mandona, K., Panossian, A., Flint, M., Ranson, R. N., Saffrey, M. J. & Yeoman, M. 15 Feb 2017 7

Research output: Contribution to journalArticle

Open Access
File
Hydroxyindoleacetic Acid
Tumor Necrosis Factor-alpha
Constipation
Water
Colon

Restraint and social isolation stressors differentially regulate adaptive immunity and yumor angiogenesis in a breast cancer mouse model

Budiu, R. A., Vlad, A. M., Nazario, L., Bathula, C., Cooper, K. L., Edmed, J., Thaker, P. H., Urban, J., Kalinski, P., Lee, A. V., Elishaev, E. L., Conrads, T. P. & Flint, M. 11 Nov 2016 6, 1

Research output: Contribution to journalArticle

Open Access
File
Social Isolation
Adaptive Immunity
Breast Neoplasms
Neoplasms
Immune System

Activities 2016 2016

  • 1 Research degree

Heat sensitivity and alleviating strategies for female breast cancer survivors

Maxwell, N. (Supervisor), Flint, M. (Supervisor), Beale, L. (Supervisor)
2016 → …

Activity: Research degree