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Personal profile

Research interests

My research interest is cartilage – often thought of as an inert, gristly material, in reality is a fascinating tissue.

Articular cartilage

Articular cartilage – lines the surface of bones of articulating joints, protecting the underlying bone from the mechanical forces associated with movement and support. Degeneration of articular cartilage results in chronic diseases affecting millions of people in the UK alone, osteoarthritis (OA) being the most common. OA was once thought of as simply a result of wear and tear, but it is now believed the resident cells of cartilage, chondrocytes, play a key role in its initiation and progression. Currently we know little of the disease process, and consequently the treatment options are limited.

Chondrocyte morphology has been observed to change in osteoarthritis cartilage, indicating a shift in cell phenotype. My work with Dr Andrew Hall (University of Edinburgh) has identified an increased number of these cells and their expression of the powerful inflammatory cytokine interleukin 1beta (IL-1beta) with the progression of osteoarthritis. Indeed, cell changes have been observed in apparently normal articular cartilage suggesting a role in the initiation of the disease process. Researchers are further investigating this novel observation.

One treatment option for patients suffering from OA is joint resurfacing using osteochondral (bone+cartilage) donor grafts (mosaicplasty). Unfortunately, availability of suitable and safe tissue is limited due to the lack of options for tissue storage. My research group is interested in how to improve upon this, developing novel techniques to allow successful cryopreservation of articular cartilage.

Growth plate cartilage

The growth plate, also known as the epiphyseal plate, is entirely responsible for bone lengthening through childhood and adolescence. It is a fundamental process, driven by the increase in volume of growth plate chondrocytes, but the cellular mechanisms are relatively unknown. I am interested in how these cells increase their size, and what regulates the change in volume.

Osteosarcoma

Osteosarcomas are bone cancers which predominantly affect children and adolescents; they typically occur next to the growth plate. MicroRNAs (miRNAs) are small non-coding RNAs which are an important regulator of gene expression in cells, and may be involved in osteosarcoma. In collaboration with colleagues at the  Brighton and Sussex Medical School (Dr Sarah Newbury’s group) we are investigating the potential role of the miRNA XRN1.

Education/Academic qualification

PhD, University of Aberdeen

1 Aug 19921 Mar 1997

Bachelor, University of Portsmouth

Sep 1989Jun 1992

Keywords

  • QP Physiology

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Chondrocytes Medicine & Life Sciences
Tissue Inhibitor of Metalloproteinase-3 Medicine & Life Sciences
Osteoarthritis Medicine & Life Sciences
Interleukin-1beta Medicine & Life Sciences
Growth Plate Medicine & Life Sciences
Cartilage Medicine & Life Sciences
Biomimetics Engineering & Materials Science
Articular Cartilage Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1995 2018

Engineering of TIMP‐3 as a LAP‐fusion protein for targeting to sites of inflammation

Alberts, B., Sacre, S., Bush, P. & Mullen, L. 18 Nov 2018 5 p.

Research output: Contribution to journalArticle

Open Access
File
Tissue Inhibitor of Metalloproteinase-3
Protein Transport
Inflammation
Peptides
Matrix Metalloproteinases

MRI-informed Biomimetic Design of Artificial Intervertebral Disc Scaffolds using 3D Bioplotting

Hodder, E., Covill, D., Bush, P., Cercignani, M., Dowell, N. G., Overall, A., Gelinsky, M., Lode, A. & Duin, S. 1 Dec 2017 p. 0-0 1 p.

Research output: Contribution to conferenceAbstract

Open Access
File
Biomimetics
Scaffolds (biology)
Magnetic resonance imaging

Abnormal human chondrocyte morphology is related to increased levels of cell-associated IL-1 beta and disruption to pericellular collagen yype VI

Murray, D. H., Bush, P., Brenkel, I. J. & Hall, A. C. 30 Nov 2010 28, 11, p. 1507-1514 8 p.

Research output: Contribution to journalArticle

Chondrocytes
Interleukin-1beta
Collagen Type VI
Collagen
Fluorescence

A cell shrinkage artefact in growth plate chondrocytes with common fixative solutions: importance of fixative osmolarity for maintaining morphology

Loqman, M. Y., Bush, P., Farquharson, C. & Hall, A. C. May 2010 14, 19, p. 214-227 14 p.

Research output: Contribution to journalArticle

Open Access
File

A key role for membrane transporter NKCC1 in mediating chondrocyte volume increase in the mammalian growth plate

Bush, P., Pritchard, M., Loqman, M. Y., Damron, T. A. & Hall, A. C. Jul 2010 25, 7, p. 1594-1603 10 p.

Research output: Contribution to journalArticle