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2019

Off-target interactions as novel explantion of NSAID CV risk

Dolan, G., MacKenzie, L., Zloh, M. & Lione, L., Apr 2019.

Research output: Contribution to conferenceAbstract

Open Access
File
Cardiovascular Agents
Anti-Inflammatory Agents
Diclofenac
Naproxen
Cytoplasmic and Nuclear Receptors

Regulation of pulmonary artery inflamation by PPARβ/δ

Perez Diaz, N., Lione, L., MacKenzie, L. & Hutter, V., Apr 2019.

Research output: Contribution to conferenceAbstract

Open Access
File
PPAR delta
Pulmonary Artery
Inflammation
Transcription Factors
Anti-Inflammatory Agents
2018

An overview of anti-diabetic plants used in Gabon: Pharmacology and toxicology

Bading Taika, B., Bouckandou, M., Souza, A., Bourobou Bourobou, H. P., Mackenzie, L. & Lione, L. A., 2 Jan 2018, In : Journal of Ethnopharmacology. 216, p. 203-228 26 p.

Research output: Contribution to journalArticle

Open Access
File
Gabon
Toxicology
Pharmacology
Hyperglycemia
Tabernaemontana

Predicted interactions of selected NSAIDS with hERG potassium channel using Virtual Toxlab

Dolan, G., MacKenzie, L., Zloh, M. & Lione, L., Mar 2018.

Research output: Contribution to conferenceAbstract

Open Access
File
Celecoxib
Potassium Channels
Anti-Inflammatory Agents
Cardiac Arrhythmias
etoricoxib

The non-genomic effects of the PPARβ/δ agonist GW0742 on STZ treated rat aorta

Perez-Diaz, N., Pushkarsky, I., Oweis, N., Lione, L. A. & Mackenzie, L., 31 Dec 2018, In : Current Molecular Pharmacology. 11, 2, p. 149-154 6 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Aorta
Dilatation
GW0742
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
2017

Exploration of the structural differences between safe and unsafe NSAIDs using 3D molecular similarity

Dolan, G., MacKenzie, L. & Zloh, M., Dec 2017.

Research output: Contribution to conferenceAbstract

Open Access
File
etoricoxib
Naproxen
Anti-Inflammatory Agents
Pharmaceutical Preparations
Drug-Related Side Effects and Adverse Reactions

Identifying compounds that inhibit S100P – RAGE binding as a novel therapy for pancreatic cancer

Ogbeni, D., Camara, R., Chau, D., Patel, P., Kirton, S., MacKenzie, L. & Rossiter, S., 5 Jul 2017.

Research output: Contribution to conferenceAbstract

Open Access
File

Identifying inhibitor of S100P – RAGE binding as a novel therapy for pancreatic cancer

Ogbeni, D., Camara, R., Kirton, S., Patel, P., Crnogorac-Jurcevic, T., MacKenzie, L., Chau, D. & Rossiter, S., 5 Sep 2017.

Research output: Contribution to conferenceAbstract

Open Access
File

New Drugs for Pancreatic Cancer

Ogbeni, D., Chau, D., Patel, P., Rossiter, S. & MacKenzie, L., 13 Mar 2017.

Research output: Contribution to conferenceAbstract

Open Access
File
Pancreatic Neoplasms
Pharmaceutical Preparations
Neoplasms
Cell Movement
Adenocarcinoma

Novel compounds for the inhibition of S100P binding with RAGE as a potential therapy for pancreatic cancer

Ogbeni, D., Camara, R., Kirton, S., Crnogorac-Jurcevic, T., MacKenzie, L., Chau, D. & Rossiter, S., 5 Jul 2017.

Research output: Contribution to conferenceAbstract

Open Access
File

This new treatment could make pancreatic cancer a manageable disease

Ogbeni, D. & MacKenzie, L., 9 Feb 2017, The Conversation.

Research output: Other contribution

Open Access

Thyroid Hormone Receptor Antagonists; from Environmental Pollution to Novel Small Molecules

Mackenzie, L., 5 Jun 2017, Vitamins and Hormones. Litwack, G. (ed.). UK: Elsevier, Vol. 106. p. 147-162 16 p. (Vitamins and Hormones).

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapter

Hormone Antagonists
Thyroid Hormone Receptors
Environmental Pollution
Hyperthyroidism
Physiological Phenomena
2016

A New NO-Releasing Nanoformulation for the Treatment of Pulmonary Arterial Hypertension

Mohamed, N. A., Ahmetaj-Shala, B., Duluc, L., Mackenzie, L., Kirkby, N. S., Reed, D. M., Lickiss, P. D., Davies, R. P., Freeman, G. & Wojciak-Stothard, B., 9 Mar 2016, In : Journal of Cardiovascular Translational Research. 9, 2, p. 162-164 3 p.

Research output: Contribution to journalArticle

Open Access
File
Pulmonary Hypertension
Nitric Oxide
Nanomedicine
Hydrogel
Half-Life

Can NSAIDs alter thyroid hormone function?

MacKenzie, L., 26 Apr 2016, The Atlas of Science .

Research output: Other contribution

Open Access

Can NSAIDs alter Thyroid Hormone Function?

MacKenzie, L., 28 Sep 2016.

Research output: Contribution to conferenceAbstract

Celecoxib
Thyroid Hormones
Anti-Inflammatory Agents
Diclofenac
Pharmaceutical Preparations

Evidence that Diclofenac and Celecoxib are thyroid hormone receptor beta antagonists

Zloh, M., Perez-Diaz, N., Tang, L., Patel, P. & Mackenzie, L., 1 Feb 2016, In : Life Sciences. 146, p. 66-72 7 p.

Research output: Contribution to journalArticle

Celecoxib
Thyroid Hormone Receptors beta
Diclofenac
Naproxen
Non-Steroidal Anti-Inflammatory Agents

Methylglyoxal, A Metabolite Increased in Diabetes is Associated with InsulinResistance, Vascular Dysfunction and Neuropathies

Shamsaldeen, Y. A., Mackenzie, L., Lione, L. A. & Benham, C. D., 1 Jan 2016, In : Current Drug Metabolism. 17, 4, p. 359-367 9 p.

Research output: Contribution to journalArticle

Open Access
File
Pyruvaldehyde
Blood Vessels
Diabetes Complications
Hyperglycemia
Bibliographic Databases
2015

ELISA screen of novel compounds that inhibit S100P and RAGE binding to identify new candidate drugs as a new therapy for pancreatic cancer

Ogbeni, D., Camara, R., Chau, D., Kirton, S., Rossiter, S. & MacKenzie, L., 2015.

Research output: Contribution to conferenceAbstract

Open Access
File
Pancreatic Neoplasms
Enzyme-Linked Immunosorbent Assay
Pharmaceutical Preparations
Therapeutics
Adenocarcinoma

Evidence that Diclofenac and Celecoxib are Thyroid Hormone Receptor Beta Antagonists; use of in silico, Molecular and Pharmacological Techniques

Perez Diaz, N., Zloh, M., Patel, P. & MacKenzie, L., Dec 2015.

Research output: Contribution to conferenceAbstract

Open Access
File
Celecoxib
Thyroid Hormone Receptors beta
Diclofenac
Non-Steroidal Anti-Inflammatory Agents
Computer Simulation

Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: novel explanation of cardiovascular side effects associated with anti-inflammatory drugs

Ahmetaj-Shala, B., Kirkby, N. S., Knowles, R., Al’Yamani, M., Mazi, S., Wang, Z., Tucker, A. T., Mackenzie, L., Armstrong, P. C. J. & Nusing, R. M., 27 Oct 2015, In : Circulation. 131, 7, p. 633-642 10 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2
Anti-Inflammatory Agents
Kidney
omega-N-Methylarginine
Biomarkers
Open Access
File
Pancreatic Neoplasms
Calcium-Binding Proteins
Neoplasm Metastasis
Neoplasms
Therapeutics

In silico modelling of prostacyclin and other lipid mediators to nuclear receptors reveal novel thyroid hormone receptor antagonist properties

Perez-Diaz, N., Zloh, M., Patel, P. & Mackenzie, L., 11 Dec 2015, In : Prostaglandins & Other Lipid Mediators. 122, p. 18-27 10 p.

Research output: Contribution to journalArticle

beraprost
Hormone Antagonists
Thyroid Hormone Receptors
Epoprostenol
Cytoplasmic and Nuclear Receptors

Linking Induction and Transrepression of PPARβ/δ with Cellular Function

Perez-Diaz, N. & Mackenzie, L., 26 Jan 2015, In : Annual Research and Review in Biology. 6, 4, p. 253-263 11 p.

Research output: Contribution to journalArticle

Open Access
File
Peroxisome Proliferator-Activated Receptors
Cytoplasmic and Nuclear Receptors
Ligands
Drug and Narcotic Control
Drug Design

Reply to Letter Regarding Article, "Evidence That Links Loss of Cyclooxygenase-2 With Increased Asymmetric Dimethylarginine: Novel Explanation of Cardiovascular Side Effects Associated With Anti-Inflammatory Drugs

Ahmetaj-Shala, B., Kirkby, N. S., Knowles, R., Al’Yamani, M., Mazi, S., Wang, Z., Tucker, A. T., Mackenzie, L., Armstrong, P. C. J. & Nusing, R. M., 24 Nov 2015, In : Circulation. 132, 17, p. 213-214 2 p.

Research output: Contribution to journalArticle

Targeting PPARbeta/delta in lung disease

MacKenzie, L., 1 Dec 2015.

Research output: Contribution to conferenceAbstract

2014

Role of prostacyclin in pulmonary hypertension

Mitchell, J., Ahmetaj-Shala, B., Kirkby, N. S., Wright, W. R., Mackenzie, L., Reed, D. M. & Mohamed, N. A., 31 Dec 2014, In : Global Cardiology Science and Practice. 4, p. 382-393 12 p.

Research output: Contribution to journalArticle

Open Access
File
Epoprostenol
Pulmonary Hypertension
Lung
Epoprostenol Receptors
Hormones

Selective inhibition of NADPH Oxidase reverses the over contraction of diabetic rat aorta

Rehman, A. U., Dugic, E., Benham, C. D., Lione, L. A. & Mackenzie, L., 1 Jan 2014, In : Redox Biology. 2, p. 61-64 4 p.

Research output: Contribution to journalArticle

Open Access
File
NADPH Oxidase
Aorta
Phenylephrine
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Reactive Oxygen Species
2013

Aspirin triggered 15-epi-lipoxin A4 predicts cyclo-oxygenase-2 in the lungs of LPS treated mice but not in the circulation: implications for a clinical test

Kirkby, N. S., Chan, M., Lundberg, M. H., Massey, K. A., Edmands, W. M. B., Mackenzie, L., Holmes, E., Nicolaou, A., Warner, T. D. & Mitchell, J., 1 Jun 2013, In : Faseb journal. 27, 10, p. 3938-3946 9 p.

Research output: Contribution to journalArticle

Open Access
File
Prostaglandin-Endoperoxide Synthases
Aspirin
Cyclooxygenase 2
Lipoxins
Lung

Cross-talk between toll-like receptor 4 (TLR4) and proteinase-activated receptor 2 (PAR) is involved in vascular function

Bucci, M., Vellecco, V., Harrington, L., Brancaleone, V., Roviezzo, F., Mattace Raso, G., Ianaro, A., Lungarella, G., De Palma, R. & Meli, R., 1 Jan 2013, In : British Journal of Pharmacology. 168, 2, p. 411-420 10 p.

Research output: Contribution to journalArticle

PAR-2 Receptor
Toll-Like Receptor 4
Blood Vessels
Peptides
Vasodilation

Harnessing the benefits of PPARβ/δ agonists

Mackenzie, L. & Lione, L. A., 18 Dec 2013, In : Life Sciences. 93, 25-26, p. 963-967 5 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Mediator Complex
Clinical Trials
Lipids
Research

LC-MS/MS Confirms That COX-1 Drives Vascular Prostacyclin Whilst Gene Expression Pattern Reveals Non-Vascular Sites of COX-2 Expression

Kirkby, N. S., Zaiss, A. K., Urquhart, P., Jiao, J., Austin, P. J., Al’Yamani, M., Lundberg, M. H., Mackenzie, L., Warner, T. D. & Nicolaou, A., 9 Jul 2013, In : PLoS ONE. 8, 7

Research output: Contribution to journalArticle

Open Access
File
Cyclooxygenase 1
Epoprostenol
Cyclooxygenase 2
Blood Vessels
Gene Expression

Linking phospholipase C isoforms with differentiation function in human vascular smooth muscle cells

Mackenzie, L., Lymn, J. S. & Hughes, A. D., 14 Aug 2013, In : BBA - Molecular Cell Research. 1833, 12, p. 3006-3012 7 p.

Research output: Contribution to journalArticle

Open Access
File
Type C Phospholipases
Vascular Smooth Muscle
Smooth Muscle Myocytes
Protein Isoforms
Actins
2012

Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system

Kirkby, N. S., Lundberg, M. H., Harrington, L., Leadbeater, P. D. M., Milne, G., Potter, C. M. F., Al’Yamani, M., Adeyemi, O., Warner, T. D. & Mitchell, J., 23 Oct 2012, In : Proceedings of the National Academy of Sciences. 109, 43, p. 17597-17602 6 p.

Research output: Contribution to journalArticle

Cyclooxygenase 1
Epoprostenol
Cyclooxygenase 2
Cardiovascular System
Endothelium

Role of RhoB in the regulation of pulmonary endothelial and smooth muscle cell responses to hypoxia

Wojciak-Stothard, B., Zhao, L., Oliver, E., Dubois, O., Wu, Y., Kardassis, D., Vasilaki, E., Huang, M., Mitchell, J. & Harrington, L., 25 May 2012, In : Circulation Research. 110, 11, p. 1423-1434 12 p.

Research output: Contribution to journalArticle

Smooth Muscle Myocytes
Lung
Pulmonary Hypertension
Farnesyltranstransferase
Blood Vessels
2011

Reduced endothelial dependent vasodilation in vessels from TLR4 mice is associated with increased superoxide generation

Harrington, L., Lundberg, M. H., Waight, M., Rozario, A. & Mitchell, J., 20 May 2011, In : Biochemical and biophysical research communications. 408, 4, p. 511-515 5 p.

Research output: Contribution to journalArticle

Open Access
File
Vasodilation
Superoxides
Mesenteric Arteries
Toll-Like Receptor 4
Vasodilator Agents

Role of shear stress in endothelial cell morphology and expression of cyclooxygenase isoforms

Potter, C. M. F., Lundberg, M. H., Harrington, L., Warboys, C. M., Warner, T. D., Berson, R. E., Moshkov, A. V., Gorelik, J., Weinburg, P. D. & Mitchell, J., 1 Feb 2011, In : Arteriosclerosis Thrombosis and Vascular Biology. 31, 2, p. 384-391 8 p.

Research output: Contribution to journalArticle

Cyclooxygenase 1
Prostaglandin-Endoperoxide Synthases
Protein Isoforms
Cyclooxygenase 2
Endothelial Cells
2010

Nucleotide oligomerization domain 1 is a dominant pathway for NOS2 induction in vascular smooth muscle cells: comparison with Toll-like receptor 4 responses in macrophages

Moreno, L., McMaster, S. K., Gatheral, T., Harrington, L., Cartwright, N., Armstrong, P. C. J., Warner, T. D., Paul-Clark, M. & Mitchell, J., 1 Aug 2010, In : British Journal of Pharmacology. 160, p. 1997-2007 11 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Vascular Smooth Muscle
Smooth Muscle Myocytes
Nucleotides
Macrophages

The PPARβ/δ agonist GW0742 relaxes pulmonary vessels and limits right heart hypertrophy in rats with hypoxia-induced pulmonary hypertension

Harrington, L., Moreno, L., Reed, A., Wort, S. J., Desvergne, B., Garland, C., Zhao, L. & Mitchell, J., 4 Mar 2010, In : PLoS ONE. 5, 3

Research output: Contribution to journalArticle

Open Access
File
Peroxisome Proliferator-Activated Receptors
PPAR-beta
Cardiomegaly
Pulmonary Hypertension
Lung