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Mark Yeoman

Dr, Ph.D Neuropharmacology, Director of the Centre for Stress and Age-related Disease

 https://orcid.org/0000-0003-2113-8650
1995 …2023
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Research Output 1995 2019

2019

Determination of tryptophan metabolism from biological tissues and fluids using high performance liquid chromatography with simultaneous dual electrochemical detection

Brooks, E., Mutengwa, V., Abdalla, A., Yeoman, M. & Patel, B., 16 Sep 2019, In : Analyst. 144, 20, p. 6011-6018 8 p.

Research output: Contribution to journal › Article

High performance liquid chromatography
Kynurenine
Metabolism
Tryptophan
Tissue

Region specific differences in the effect of propofol on the murine colon result in dysmotility

Diss, L., Villeneuve, S., Pearce, K., Yeoman, M. & Patel, B., 29 Mar 2019, In : Autonomic Neuroscience-Basic & Clinical. 219, p. 19-24 6 p.

Research output: Contribution to journal › Article

Propofol
Colon
Maintenance
Intravenous Anesthetics
Nitric Oxide Synthase

Three-Dimensional-Printed Electrochemical Sensor for Simultaneous Dual Monitoring of Serotonin Overflow and Circular Muscle Contraction

Bin Hamzah, H., Keattch, O., Yeoman, M., Covill, D. & Patel, B., 27 Aug 2019, In : Analytical Chemistry. 91, 18, p. 12014-12020 7 p.

Research output: Contribution to journal › Article

Electrochemical sensors
Muscle
Serotonin
Monitoring
Sensors
2018

BBSRC Pathfinder - Technology Market Assessment and Patent Landscape Analysis for use of TNF-α Antagonists in the Management of Constipation in the Elderly

Yeoman, M. & Patel, B., 2018, 54 p.

Research output: Book/Report › Commissioned report

File
Biomedical Technology Assessment
Constipation
Drug Prescriptions
Immunologic Factors
Ulcerative Colitis

Changes in murine anorectum signaling across the life course

Fidalgo, S., Patel, B., Ranson, R., Saffrey, J. & Yeoman, M., 30 Jul 2018, In : Neurogastroenterology and Motility. 30, 10, p. 13426-13438 13 p., e13426.

Research output: Contribution to journal › Article

Open Access
File
Fecal Impaction
Acetylcholine
Constipation
Cholinergic Agents
Nitric Oxide

Does the 5-HT1A rs6295 polymorphism influence the safetyand efficacy of citalopram therapy in the oldest old?

Scutt, G., Overall, A., Scott, R., Patel, B., Hachoumi, L., Yeoman, M. & Wright, J., 23 Apr 2018, In : Therapeutic Advances in Drug Safety. 9, 7, p. 355-366

Research output: Contribution to journal › Article

Open Access
File
Citalopram
Genotype
Major Depressive Disorder
Bayes Theorem
Antidepressive Agents

Interstitial cell network volume is reduced in the terminal bowel of ageing mice

Gamage, P. P. K. M., Patel, B. A., Yeoman, M. S., Ranson, R. N. & Jill Saffrey, M., 25 Jul 2018, In : Journal of Cellular and Molecular Medicine.

Research output: Contribution to journal › Article

Open Access
File
Interstitial Cells of Cajal
Cell Size
Gastrointestinal Tract
Anal Canal
Rectum
2017

The TNF-α antagonist etanercept reverses age-related decreases in colonic SERT expression and faecal output in mice

Patel, B., Fidalgo, S., Wang, C., Parmar, L., Mandona, K., Panossian, A., Flint, M., Ranson, R. N., Saffrey, M. J. & Yeoman, M., 15 Feb 2017, In : Scientific Reports. 7

Research output: Contribution to journal › Article

Open Access
File
Hydroxyindoleacetic Acid
Constipation
Water
Colon
Etanercept
2016

Acute paraquat exposure impairs colonic motility by selectively attenuating nitrergic signaling in the mouse

Diss, L., Dyball, S., Ghela, T., Golding, J., Morris, R., Robinson, S., Tucker, R., Walter, T., Young, P., Allen, M., Fidalgo, S., Gard, P., Mabley, J., Patel, B., Chatterjee, P. & Yeoman, M., 30 Jan 2016, In : Autonomic Neuroscience-Basic & Clinical. 195, p. 8-15 8 p.

Research output: Contribution to journal › Article

Open Access
File
Paraquat
Migrating Myoelectric Complexes
Gastrointestinal Tract
Colon
Myenteric Plexus

Does Age Matter? The Impact of Rodent Age on Study Outcomes

Jackson, S., Andrews, N., Ball, D., Bellatntuono, L., Gray, J., Hachoumi, L., Holmes, A., Latcham, J., Petrie, A., Potter, P., Rice, A., Ritchie, A., Stewart, M., Strepka, C., Yeoman, M. & Chapman, K., 15 Jun 2016, In : Laboratory Animals. 51, 2, p. 160-169 10 p.

Research output: Contribution to journal › Article

Open Access
File
Rodentia
Outcome Assessment (Health Care)
Research Design
Cell Aging
Research

Electrochemical sensor for the detection of multiple reactive oxygen and nitrogen species from ageing central nervous system homogenates

Fagan-Murphy, A., Hachoumi, L., Yeoman, M. & Patel, B., 14 Oct 2016, In : Mechanisms of Ageing and Development. 160, p. 28-31 4 p.

Research output: Contribution to journal › Article

Open Access
File
2015

A switch in the mode of the sodium/calcium exchanger underlies an age-related increase in the slow afterhyperpolarization

Scutt, G., Allen, M., Kemenes, G. & Yeoman, M., 1 Oct 2015, In : Neurobiology of Aging. 36, 10, p. 2838-2849 12 p.

Research output: Contribution to journal › Article

Open Access
File
Sodium-Calcium Exchanger
Giant Cells
Cell Aging
Lymnaea
Snails
2014

Impaired colonic motility and reduction in tachykinin signalling in the aged mouse

Patel, B., Patel, N., Fidalgo, S., Wang, C., Ranson, R. N., Saffrey, M. J. & Yeoman, M., 31 May 2014, In : Experimental Gerontology. 53, p. 24-30 7 p.

Research output: Contribution to journal › Article

2013

Age-related changes in melatonin release in the murine distal colon

Diss, L. B., Robinson, S. D., Wu, Y., Fldalgo, S., Yeoman, M. & Patel, B., 30 Apr 2013, In : ACS Chemical Neuroscience. 4, 5, p. 879-887 9 p.

Research output: Contribution to journal › Article

Melatonin
Colon
Constipation
Serotonin
Fecal Impaction

Biomarkers, interventions and healthy ageing

Kenessary, A., Zhumadilov, Z., Nurgozhin, T., Kipling, D., Yeoman, M., Cox, L., Ostler, E. & Faragher, R., 25 May 2013, In : New Biotechnology. 30, 4, p. 373-377 5 p.

Research output: Contribution to journal › Article

Biomarkers
Aging of materials
Morbidity
Quality of Life
Pathology

Changes in the innervation of the mouse internal anal sphincter during aging

Wang, C., Houghton, M. J., Gamage, P. P. K. M., Collins, H. E., Patel, B., Yeoman, M., Ranson, R. N. & Saffrey, M. J., 1 May 2013, In : Neurogastroenterology and Motility. 25, 7

Research output: Contribution to journal › Article

Anal Canal
Nerve Fibers
Mucous Membrane
Nitric Oxide Synthase Type I
Muscles

Myenteric neuron numbers are maintained in aging mouse distal colon

Gamage, P. P. K. M., Ranson, R. N., Patel, B., Yeoman, M. & Saffrey, M. J., 20 Mar 2013, In : Neurogastroenterology and Motility. 25, 7

Research output: Contribution to journal › Article

Colon
Neurons
Nitric Oxide Synthase Type I
Nerve Fibers
Nitrergic Neurons
2012

Age-related change in cholinergic and nitrergic signaling in the mouse rectum

Patel, B., Fidalgo, S., Ranson, R. N., Saffrey, M. J. & Yeoman, M., 30 Sep 2012, p. 120-120. 1 p.

Research output: Contribution to conference › Abstract

Age-related changes in colonic motility, faecal output and the properties of faecal pellets in the mouse

Patel, B., Patel, N., Fidalgo, S., Ranson, R. N., Saffery, J. & Yeoman, M., 30 Sep 2012, In : Neurogastroenterology and Motility. 24

Research output: Contribution to journal › Article

Analysis of changes in the cells of the mouse internal anal sphincter during aging

Saffrey, M. J., Wang, C., Gamage, P. P. K. M., Davies, H., Colyer, F., Houghton, M. J., Patel, B., Yeoman, M. & Ranson, R. N., 30 Sep 2012, p. 125-125. 1 p.

Research output: Contribution to conference › Abstract

Chromatographic analysis of age-related changes in mucosal serotonin transmission in the murine distal ileum

Parmar, L., Fidalgo, S., Yeoman, M. & Patel, B., 31 Dec 2012, In : Chemistry Central Journal. 6, 1

Research output: Contribution to journal › Article

Open Access
File
Ileum
Chromatography
Serotonin
Hydroxyindoleacetic Acid
5-Hydroxytryptophan

Chromatographic assay to study the activity of multiple enzymes involved in the synthesis and metabolism of dopamine and serotonin

Patel, B., Yeoman, M., Morgan, L. D. & Baker, H., 31 Dec 2012, In : Analyst. 137, 6, p. 1409-1415 7 p.

Research output: Contribution to journal › Article

Decrease in serotonin-induced tachykinin signaling can account for age: Related reductions in the amplitude and the frequency of Colonic Migrating Motor Complexes (CMMCS) in the murine distal colon

Patel, B., Yeoman, M., Fidalgo, S., Dhulia, P., Girdlestone, I., Ranson, R. N. & Saffrey, M. J., 30 Sep 2012, In : Neurogastroenterology and Motility. 24, p. 128-128 1 p.

Research output: Contribution to journal › Article

Effect of age on mucosal serotonin signalling and circular muscle contractions in the murine rectum

Patel, B., Parmar, L., Fidalgo, S., Wang, C., Ranson, R. N., Saffrey, M. J. & Yeoman, M., 30 Sep 2012, p. 84-84. 1 p.

Research output: Contribution to conference › Abstract

Insights into CNS ageing from animal models of senescence

Yeoman, M., Scutt, G. & Faragher, R., 30 Jun 2012, In : Nature Reviews Neuroscience. 13, 6, p. 435-445 11 p.

Research output: Contribution to journal › Article

2011

The effect of Alzheimer's disease - Associated β-amyloid peptide on voltage-dependant currents in a human-derived cell line

MacKenzie, L., Killock, R., Mayne, L. & Yeoman, M. S., 12 Apr 2011, In : Journal of Pharmacy and Pharmacology. 50, S9, 1 p.

Research output: Contribution to journal › Article

2010

Microelectrode investigation of neuroneal ageing from a single identified neurone

Patel, B., Arundell, M., Parker, K. H., Yeoman, M. & O'Hare, D., 12 Jul 2010, In : Physical Chemistry Chemical Physics. 12, 34, p. 10065-10072 8 p.

Research output: Contribution to journal › Article

Microelectrodes
Serotonin
Nitric Oxide
Lymnaea
Neurons
2009

Transcriptome analysis of the central nervous system of the mollusc Lymnaea stagnalis

Feng, Z. P., Zhang, Z., Van Kesteren, R. E., Straub, V. A., Van Neirop, P., Jin, K., Nejatbakhsh, N., Goldberg, J. I., Spencer, G. E., Yeoman, M. S., Wildering, W., Coorssen, J. R., Croll, R. P., Buck, L. T., Syed, N. I. & Smit, A. B., 2009, In : BMC Genomics. 10, 451

Research output: Contribution to journal › Article

Open Access
File
2008

Synapse-specific changes in serotonin signalling contribute to age-related changes in the feeding behaviour of the pond snail, Lymnaea

Yeoman, M., Patel, B., Arundell, M., Parker, K. & O'Hare, D., 28 Jun 2008, In : Journal of Neurochemistry. 106, 4, p. 1699-1709 11 p.

Research output: Contribution to journal › Article

File
2007

Renin- angiotensin- system gene polymorphisms and depression

Saab, Y., Gard, P., Yeoman, M., El-Moalem, H., Mfarrej, B. & Ingram, M., 30 Jun 2007, In : Progress in Neuro-Psychopharmacology and Biological Psychiatry. 31, 5, p. 1113-1118 6 p.

Research output: Contribution to journal › Article

Renin-Angiotensin System
Depression
Angiotensin Type 1 Receptor
Angiotensin Receptors
Genes
2006

Changes in the properties of the modulatory cerebral giant cells contribute to aging in the feeding system of Lymnaea

Patel, B., Arundell, M., Allen, M., Gard, P., O'Hare, D., Parker, K. & Yeoman, M., 1 Dec 2006, In : Neurobiology of Aging. 27, 12, p. 1892-1901 10 p.

Research output: Contribution to journal › Article

Lymnaea
Giant Cells
Feeding Behavior
Aptitude
Motor Neurons

Detection of nitric oxide release from single neurons in the pond snail, Lymnaea stagnalis

Patel, B., Arundell, M., Parker, K. H., Yeoman, M. & O'Hare, D., Aug 2006, In : Analytical Chemistry. 78, 22, p. 7643-7648 6 p.

Research output: Contribution to journal › Article

Effects of age on feeding behavior and chemosensory processing in the pond snail, Lymnaea stagnalis

Arundell, M., Patel, B., Straub, V., Allen, M., Janse, C., O'Hare, D., Parker, K., Gard, P. & Yeoman, M., Dec 2006, In : Neurbiology of Aging. 27, 12, p. 1880-1891 12 p.

Research output: Contribution to journal › Article

Lymnaea
Snails
Feeding Behavior
Sucrose
Lip

Novel subsecond voltametric separation betwen dopamine and serotonin in the presence of ascorbate

Anastassiou, C. A., Patel, B. A., Arundell, M., Yeoman, M., Parker, K. H. & O'Hare, D., Aug 2006, In : Analtical Chemistry. 78, 19, p. 6990-6998 9 p.

Research output: Contribution to journal › Article

Dopamine
Serotonin
Neurotransmitter Agents
Electric potential
Molecules

Subsecond voltametric separation between dopamine and serotonin in the presence of ascorbate

Anastassiou, C. A., Patel, B., Arundell, M., Yeoman, M., Parker, K. H. & O'Hare, D., Aug 2006, In : Analytical Chemistry. 78, 19, p. 6990-6998 9 p.

Research output: Contribution to journal › Article

Dopamine
Serotonin
Neurotransmitter Agents
Electric potential
Molecules
2005

Decreases in the serotonin content of a pair of identified neurones can explain the effect of p-chlorophenylanaline on the feeding behaviour of the pond snail, lymnaea stagnalis

Patel, B., Arundell, M., Parker, K., Yeoman, M. & O'Hare, D., 2005, In : Current Separations. 21, 2, p. 53-58 6 p.

Research output: Contribution to journal › Article

Simple and rapid determination of serotonin and catecholamines in biological tissue using high-performance liquid chromatography with electrochemical detection

Patel, B., Arundell, M., Parker, K. H., Yeoman, M. & O'Hare, D., Apr 2005, In : Journal of Chromatography B. 818, 2, p. 269-276 8 p.

Research output: Contribution to journal › Article

High performance liquid chromatography
Catecholamines
Serotonin
Tissue
Dopamine
2004

Endothelin-1 inhibits mucin secretion from ovine airway epithelial goblet cells

Clancy, S. M., Yeadon, M., Parry, J., Yeoman, M., Adam, E. C., Schumacher, U. & Lethem, M., 2004, In : American Journal of Respiratory Cell and Molecular Biology. 31, p. 663-671 9 p.

Research output: Contribution to journal › Article

Hilbert transformation of voltammetric data

Arundell, M., Patel, B., Yeoman, M., Parker, K. H. & O'Hare, D., 2004, In : Electrochemical Communications. 6, 4, p. 366-372 7 p.

Research output: Contribution to journal › Article

Hilbert transform of voltammetric data

Arundell, M., Patel, B. A., Yeoman, M., Parker, K. H. & O'Hare, D., Apr 2004, In : Electrochemistry Communications. 6, 4, p. 366-372 7 p.

Research output: Contribution to journal › Article

Electrodes
Glassy carbon
Electrochemistry
Fast Fourier transforms
Oxides
2001

Ageing and the nervous system: insights from studies on invertebrates

Yeoman, M. & Faragher, R., Jun 2001, In : Biogerontology. 2, 2, p. 85-97 13 p.

Research output: Contribution to journal › Article

Invertebrates
Nervous System
Neurons
Brain
1999

LVA and HVA Ca2+ currents in ventricular muscle cells of the Lymnaea heart

Yeoman, M. S., Brezden, B. L. & Benjamin, P. R., 14 Dec 1999, In : Journal of Neurophysiology. 82, 5, p. 2428-2440 13 p.

Research output: Contribution to journal › Article

Lymnaea
Cardiac Myocytes
Nifedipine
Ions
Excitation Contraction Coupling

Two types of voltage-gated K+ currents in dissociated heart ventricular muscle cells of the snail Lymnaea stagnalis

Yeoman, M. S. & Benjamin, P. R., 14 Dec 1999, In : Journal of Neurophysiology. 82, 5, p. 2415-2427 13 p.

Research output: Contribution to journal › Article

Lymnaea
Snails
Cardiac Myocytes
Action Potentials
Tetraethylammonium
1995

Identification, Distribution and Physiological Activity of Three Novel Neuropeptides of Lymnaea: FLRlamide and pQFYRlamide Encoded by the FMRFamide Gene, and a Related Peptide

Santama, N., Wheeler, C. H., Skingsley, D. R., Yeoman, M. S., Bright, K., Kaye, I., Burke, J. F. & Benjamin, P. R., 1 Jan 1995, In : European Journal of Neuroscience. 7, 2, p. 234-246 13 p.

Research output: Contribution to journal › Article

FMRFamide
Lymnaea
Neuropeptides
Peptides
Genes