Microelectrode investigation of neuroneal ageing from a single identified neurone

Bhavik Patel; M. Arundell; K.H. Parker; Mark Yeoman; D. O'Hare

doi:10.1039/C0CP00310G

Microelectrode investigation of neuroneal ageing from a single identified neurone

Bhavik Patel, M. Arundell, K.H. Parker, Mark Yeoman, D. O'Hare

University of Brighton

Research output: Contribution to journal › Article › peer-review

Abstract

Microelectrode amperometry is uniquely suited for characterising the dynamics of neurotransmitter release, as it offers unparalleled spatial and temporal resolution. We have used carbon fibre microelectrodes to study release of the monoamineneurotransmitterserotonin (5-HT) and the gaseous transmitter nitric oxide (NO) in intact central nervous system of the water snail, Lymnaea stagnalis. Analysis of spontaneous vesicular release of 5-HT and depolarisation-induced release of NO reveals significant differences with ageing that may be associated with changes in protein structure and function.

Original language	English
Pages (from-to)	10065-10072
Number of pages	8
Journal	Physical Chemistry Chemical Physics
Volume	12
Issue number	34
DOIs	https://doi.org/10.1039/C0CP00310G
Publication status	Published - 12 Jul 2010

Bibliographical note

Access to Document

10.1039/C0CP00310GLicence: Unspecified

Cite this

@article{de530d85c1074a5f825a46ea6d320030,

title = "Microelectrode investigation of neuroneal ageing from a single identified neurone",

abstract = "Microelectrode amperometry is uniquely suited for characterising the dynamics of neurotransmitter release, as it offers unparalleled spatial and temporal resolution. We have used carbon fibre microelectrodes to study release of the monoamineneurotransmitterserotonin (5-HT) and the gaseous transmitter nitric oxide (NO) in intact central nervous system of the water snail, Lymnaea stagnalis. Analysis of spontaneous vesicular release of 5-HT and depolarisation-induced release of NO reveals significant differences with ageing that may be associated with changes in protein structure and function.",

author = "Bhavik Patel and M. Arundell and K.H. Parker and Mark Yeoman and D. O'Hare",

note = "{\textcopyright} Royal Society of Chemistry",

year = "2010",

month = jul,

day = "12",

doi = "10.1039/C0CP00310G",

language = "English",

volume = "12",

pages = "10065--10072",

journal = "Physical Chemistry Chemical Physics",

issn = "1463-9076",

number = "34",

}

TY - JOUR

T1 - Microelectrode investigation of neuroneal ageing from a single identified neurone

AU - Patel, Bhavik

AU - Arundell, M.

AU - Parker, K.H.

AU - Yeoman, Mark

AU - O'Hare, D.

PY - 2010/7/12

Y1 - 2010/7/12

N2 - Microelectrode amperometry is uniquely suited for characterising the dynamics of neurotransmitter release, as it offers unparalleled spatial and temporal resolution. We have used carbon fibre microelectrodes to study release of the monoamineneurotransmitterserotonin (5-HT) and the gaseous transmitter nitric oxide (NO) in intact central nervous system of the water snail, Lymnaea stagnalis. Analysis of spontaneous vesicular release of 5-HT and depolarisation-induced release of NO reveals significant differences with ageing that may be associated with changes in protein structure and function.

AB - Microelectrode amperometry is uniquely suited for characterising the dynamics of neurotransmitter release, as it offers unparalleled spatial and temporal resolution. We have used carbon fibre microelectrodes to study release of the monoamineneurotransmitterserotonin (5-HT) and the gaseous transmitter nitric oxide (NO) in intact central nervous system of the water snail, Lymnaea stagnalis. Analysis of spontaneous vesicular release of 5-HT and depolarisation-induced release of NO reveals significant differences with ageing that may be associated with changes in protein structure and function.

U2 - 10.1039/C0CP00310G

DO - 10.1039/C0CP00310G

M3 - Article

SN - 1463-9076

VL - 12

SP - 10065

EP - 10072

JO - Physical Chemistry Chemical Physics

JF - Physical Chemistry Chemical Physics

IS - 34

ER -

Microelectrode investigation of neuroneal ageing from a single identified neurone

Abstract

Bibliographical note

Access to Document

Fingerprint

Cite this