Microelectrode investigation of neuroneal ageing from a single identified neurone

Bhavik Patel, M. Arundell, K.H. Parker, Mark Yeoman, D. O'Hare

Research output: Contribution to journalArticle

Abstract

Microelectrode amperometry is uniquely suited for characterising the dynamics of neurotransmitter release, as it offers unparalleled spatial and temporal resolution. We have used carbon fibre microelectrodes to study release of the monoamineneurotransmitterserotonin (5-HT) and the gaseous transmitter nitric oxide (NO) in intact central nervous system of the water snail, Lymnaea stagnalis. Analysis of spontaneous vesicular release of 5-HT and depolarisation-induced release of NO reveals significant differences with ageing that may be associated with changes in protein structure and function.
Original languageEnglish
Pages (from-to)10065-10072
Number of pages8
JournalPhysical Chemistry Chemical Physics
Volume12
Issue number34
DOIs
Publication statusPublished - 12 Jul 2010

Bibliographical note

© Royal Society of Chemistry

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