Age-Related Changes in Central Nervous System 5-Hydroxytryptamine Signalling and Its Potential Effects on the Regulation of Lifespan

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapterpeer-review


Serotonin or 5-hydroxytryptamine (5-HT) is an important neurotransmitter in the central nervous system and the periphery. Most 5-HT (~99%) is found in
the periphery where it regulates the function of the gastrointestinal (GI) tract and is an important regulator of platelet aggregation. However, the remaining 1% that is found in the central nervous system (CNS) can regulate a range of physiological
processes such as learning and memory formation, mood, food intake, sleep, temperature and pain perception. More recent work on the CNS of invertebrate model systems has shown that 5-HT can directly regulate lifespan.
This chapter will focus on detailing how CNS 5-HT signalling is altered with
increasing age and the potential consequences this has on its ability to regulate
Original languageEnglish
Title of host publicationBiochemistry and Cell Biology of Ageing
Subtitle of host publicationPart III Biomedical Science
EditorsJ. Robin Harris, Viktor Korolchuk
Place of PublicationSwitzerland
PublisherSpringer Nature
Number of pages35
ISBN (Electronic)9783031214103
ISBN (Print)9783031214097
Publication statusPublished - 5 Jan 2023

Publication series

NameSub-cellular biochemistry
ISSN (Print)0306-0225

Bibliographical note

Publisher Copyright:
© 2023. The Author(s), under exclusive license to Springer Nature Switzerland AG.


  • Serotonin
  • Ageing
  • central nervous system
  • ageing
  • 5-HT2A receptor
  • Central Nervous System
  • Signal Transduction
  • serotonin transporter
  • lifespan
  • Longevity

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