Age-Related Changes in Central Nervous System 5-Hydroxytryptamine Signalling and Its Potential Effects on the Regulation of Lifespan

Mark Yeoman

doi:10.1007/978-3-031-21410-3_15

Age-Related Changes in Central Nervous System 5-Hydroxytryptamine Signalling and Its Potential Effects on the Regulation of Lifespan

, Mark Yeoman

School of Applied Sciences

Research output: Chapter in Book/Conference proceeding with ISSN or ISBN › Chapter › peer-review

Abstract

Serotonin or 5-hydroxytryptamine (5-HT) is an important neurotransmitter in the central nervous system and the periphery. Most 5-HT (~99%) is found in
the periphery where it regulates the function of the gastrointestinal (GI) tract and is an important regulator of platelet aggregation. However, the remaining 1% that is found in the central nervous system (CNS) can regulate a range of physiological
processes such as learning and memory formation, mood, food intake, sleep, temperature and pain perception. More recent work on the CNS of invertebrate model systems has shown that 5-HT can directly regulate lifespan.
This chapter will focus on detailing how CNS 5-HT signalling is altered with
increasing age and the potential consequences this has on its ability to regulate
lifespan.

Original language	English
Title of host publication	Biochemistry and Cell Biology of Ageing
Subtitle of host publication	Part III Biomedical Science
Editors	J. Robin Harris, Viktor Korolchuk
Place of Publication	Switzerland
Publisher	Springer Nature
Chapter	15
Pages	379-413
Number of pages	35
Volume	102
Edition	3
ISBN (Electronic)	9783031214103
ISBN (Print)	9783031214097
DOIs	https://doi.org/10.1007/978-3-031-21410-3_15
Publication status	Published - 5 Jan 2023

Publication series

Name	Sub-cellular biochemistry
ISSN (Print)	0306-0225

Bibliographical note

Publisher Copyright:
© 2023. The Author(s), under exclusive license to Springer Nature Switzerland AG.

Keywords

Serotonin
Ageing
central nervous system
ageing
5-HT2A receptor
Central Nervous System
Signal Transduction
serotonin transporter
lifespan
Longevity

Access to Document

10.1007/978-3-031-21410-3_15

Cite this

, & Yeoman, M. (2023). Age-Related Changes in Central Nervous System 5-Hydroxytryptamine Signalling and Its Potential Effects on the Regulation of Lifespan. In J. R. Harris, & V. Korolchuk (Eds.), Biochemistry and Cell Biology of Ageing: Part III Biomedical Science (3 ed., Vol. 102, pp. 379-413). (Sub-cellular biochemistry). Springer Nature. https://doi.org/10.1007/978-3-031-21410-3_15

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Yeoman, M 2023, Age-Related Changes in Central Nervous System 5-Hydroxytryptamine Signalling and Its Potential Effects on the Regulation of Lifespan. in JR Harris & V Korolchuk (eds), Biochemistry and Cell Biology of Ageing: Part III Biomedical Science. 3 edn, vol. 102, Sub-cellular biochemistry, Springer Nature, Switzerland, pp. 379-413. https://doi.org/10.1007/978-3-031-21410-3_15

Age-Related Changes in Central Nervous System 5-Hydroxytryptamine Signalling and Its Potential Effects on the Regulation of Lifespan. / ; Yeoman, Mark.
Biochemistry and Cell Biology of Ageing: Part III Biomedical Science. ed. / J. Robin Harris; Viktor Korolchuk. Vol. 102 3. ed. Switzerland: Springer Nature, 2023. p. 379-413 (Sub-cellular biochemistry).

Research output: Chapter in Book/Conference proceeding with ISSN or ISBN › Chapter › peer-review

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Yeoman M. Age-Related Changes in Central Nervous System 5-Hydroxytryptamine Signalling and Its Potential Effects on the Regulation of Lifespan. In Harris JR, Korolchuk V, editors, Biochemistry and Cell Biology of Ageing: Part III Biomedical Science. 3 ed. Vol. 102. Switzerland: Springer Nature. 2023. p. 379-413. (Sub-cellular biochemistry). doi: 10.1007/978-3-031-21410-3_15

Age-Related Changes in Central Nervous System 5-Hydroxytryptamine Signalling and Its Potential Effects on the Regulation of Lifespan

Abstract

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