TY - JOUR
T1 - Renin- angiotensin- system gene polymorphisms and depression
AU - Saab, Y.
AU - Gard, Paul
AU - Yeoman, Mark
AU - El-Moalem, H.
AU - Mfarrej, B.
AU - Ingram, Matthew
PY - 2007/6/30
Y1 - 2007/6/30
N2 - Given the abundance of the renin–angiotensin system (RAS) components in the brain, their importance in behavior and cognition, and the data that implicates them in the etiology and treatment of depression, it is possible that those RAS gene polymorphisms associated with increased RAS activity may also be associated with depression.
The frequencies of common polymorphisms of genes encoding for components of the RAS, namely angiotensinogen (M235T), angiotensin converting enzyme (ACE) (insertion, I; deletion, D), angiotensin receptor type I (A1166C), and angiotensin receptor type II (C3123A) were determined in DNA extracted from buccal cells from a Lebanese population of 132 depressed patients and their first-degree relative case-controls.
The angiotensin receptor type 1 (A1166C) CC genotype was significantly associated with depression (p = 0.036). None of the other common RAS-associated polymorphisms were significantly associated.
The results support the hypothesis that increased RAS activity may increase relative risk of depression in that the angiotensin receptor type 1 (A1166C) CC genotype is associated with increased responsiveness to angiotensin II.
AB - Given the abundance of the renin–angiotensin system (RAS) components in the brain, their importance in behavior and cognition, and the data that implicates them in the etiology and treatment of depression, it is possible that those RAS gene polymorphisms associated with increased RAS activity may also be associated with depression.
The frequencies of common polymorphisms of genes encoding for components of the RAS, namely angiotensinogen (M235T), angiotensin converting enzyme (ACE) (insertion, I; deletion, D), angiotensin receptor type I (A1166C), and angiotensin receptor type II (C3123A) were determined in DNA extracted from buccal cells from a Lebanese population of 132 depressed patients and their first-degree relative case-controls.
The angiotensin receptor type 1 (A1166C) CC genotype was significantly associated with depression (p = 0.036). None of the other common RAS-associated polymorphisms were significantly associated.
The results support the hypothesis that increased RAS activity may increase relative risk of depression in that the angiotensin receptor type 1 (A1166C) CC genotype is associated with increased responsiveness to angiotensin II.
U2 - 10.1016/j.pnpbp.2007.04.002
DO - 10.1016/j.pnpbp.2007.04.002
M3 - Article
SN - 0278-5846
VL - 31
SP - 1113
EP - 1118
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
IS - 5
ER -