If you made any changes in Pure these will be visible here soon.

Personal profile

Research interests

My research spans both the laboratory and the clinic. I use a scientific approach to help understand how medicines work, how they cause harm, and how they can be used more safely and effectively. In particular I am interested in why variation exists in regards to efficacy and adverse effects, and how this can be explained by genomic variation.

My PhD was in the area of neuroscience and ageing. During this work I used a number of electrophysiology techniques to understand changes that occur during ageing in a neurone that controls feeding, and learning and memory in the CNS of a model system (Lymnaea stagnalis). This model system is a useful tool to examine age-related changes to learning and memory using a top-down, systems level approach, and raises interesting questions about the mechanisms that underlie cognitive decline in humans. I continue to have an interest in this area and supervise several undergraduate students on projects related to ageing, and ageing of the central nervous system.

 

Current research I'm involved with include:

  • The role of genotype in antidepressant response in older people (Better targeting of antidepressants in older people)
  • Do Nrf2/Keap1 polymorphisms determine ADR rates in older people (The ADR gene study)
  • Changes to Nrf2/Keap1 expression during ageing in humans
  • What is the mechanism through which antipsychotics cause metabolic syndrome and induces beta cell toxicity?

 

Education/Academic qualification

PhD, University of Brighton

Keywords

  • RM Therapeutics. Pharmacology

Fingerprint Dive into the research topics where Greg Scutt is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 7 Similar Profiles
Drug-Related Side Effects and Adverse Reactions Medicine & Life Sciences
Comorbidity Medicine & Life Sciences
Genes Medicine & Life Sciences
Sodium-Calcium Exchanger Medicine & Life Sciences
Inappropriate Prescribing Medicine & Life Sciences
Citalopram Medicine & Life Sciences
Single Nucleotide Polymorphism Medicine & Life Sciences
Patient Discharge Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2013 2019

  • 7 Article
  • 1 Conference contribution with ISSN or ISBN
  • 1 Other
  • 1 Letter

Direct oral anticoagulant (DOAC)-mediated vasodilation: Role of nitric oxide

Mabley, J., Patel, J., Sayed, A., Arya, R. & Scutt, G., 12 Feb 2019, In : Thrombosis Research. 176, p. 36-38 3 p.

Research output: Contribution to journalLetterResearchpeer-review

Vasodilation
Anticoagulants
Nitric Oxide
Vitamin K
Food-Drug Interactions

The association of a single nucleotide polymorphism in the nuclear factor erythroid derived-2 like 2 (Nrf-2) gene with adverse drug reactions, multimorbidity and frailty in older people

Scutt, G., Overall, A., Bakrania, P., Krasteva, E., Parekh, N., Ali, K., Davies, G. & Rajkumar, C., 18 May 2019, In : Journals of Gerontology, Series A.

Research output: Contribution to journalArticleResearchpeer-review

Drug-Related Side Effects and Adverse Reactions
Single Nucleotide Polymorphism
Comorbidity
Genes
Blood Cells

Age-related changes to the expression of nuclear factor erythroid 2-like 2 (Nrf2), a regulatory antioxidant and xenobiotic defence gene

Scutt, G., Overall, A., Bakrania, P., Krasteva, E., Parekh, N., Ali, K., Davies, G. & Rajkumar, C., 2018, 14th International Congress of the European Geriatric Medicine Society: Advancing Geriatric Medicine in a Modern World. (European Geriatric Medicine).

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNConference contribution with ISSN or ISBNResearchpeer-review

Xenobiotics
Antioxidants
Comorbidity
Drug-Related Side Effects and Adverse Reactions
Genes

Association of a regulatory anti-oxidant and drug-metabolising gene with multi-morbidity and adverse drug reactions in older adults

Scutt, G., Overall, A., Bakrania, P., Krasteva, E., Parekh, N., Ali, K., Davies, G. & Rajkumar, C., 2018.

Research output: Contribution to conferenceOtherResearchpeer-review

Drug-Related Side Effects and Adverse Reactions
Oxidants
Comorbidity
Morbidity
Pharmaceutical Preparations

Does the 5-HT1A rs6295 polymorphism influence the safetyand efficacy of citalopram therapy in the oldest old?

Scutt, G., Overall, A., Scott, R., Patel, B., Hachoumi, L., Yeoman, M. & Wright, J., 23 Apr 2018, In : Therapeutic Advances in Drug Safety. 9, 7, p. 355-366

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Citalopram
Genotype
Major Depressive Disorder
Bayes Theorem
Antidepressive Agents