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Personal profile

Research interests

My research spans both the laboratory and the clinic. I use a scientific approach to help understand how medicines work, how they cause harm, and how they can be used more safely and effectively. In particular I am interested in why variation exists in regards to efficacy and adverse effects, and how this can be explained by genomic variation.

My PhD was in the area of neuroscience and ageing. During this work I used a number of electrophysiology techniques to understand changes that occur during ageing in a neurone that controls feeding, and learning and memory in the CNS of a model system (Lymnaea stagnalis). This model system is a useful tool to examine age-related changes to learning and memory using a top-down, systems level approach, and raises interesting questions about the mechanisms that underlie cognitive decline in humans. I continue to have an interest in this area and supervise several undergraduate students on projects related to ageing, and ageing of the central nervous system.

 

Current research I'm involved with include:

  • The role of genotype in antidepressant response in older people (Better targeting of antidepressants in older people)
  • Do Nrf2/Keap1 polymorphisms determine ADR rates in older people (The ADR gene study)
  • Changes to Nrf2/Keap1 expression during ageing in humans
  • What is the mechanism through which antipsychotics cause metabolic syndrome and induces beta cell toxicity?

 

Education/Academic qualification

PhD, University of Brighton

Keywords

  • RM Therapeutics. Pharmacology

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Research Output 2013 2018

  • 6 Article
  • 1 Conference contribution with ISSN or ISBN
  • 1 Other

Age-related changes to the expression of nuclear factor erythroid 2-like 2 (Nrf2), a regulatory antioxidant and xenobiotic defence gene

Scutt, G., Overall, A., Bakrania, P., Krasteva, E., Parekh, N., Ali, K., Davies, G. & Rajkumar, C. 2018 14th International Congress of the European Geriatric Medicine Society: Advancing Geriatric Medicine in a Modern World. (European Geriatric Medicine)

Research output: Chapter in Book/Report/Conference proceedingConference contribution with ISSN or ISBN

Xenobiotics
Antioxidants
Comorbidity
Drug-Related Side Effects and Adverse Reactions
Messenger RNA

Association of a regulatory anti-oxidant and drug-metabolising gene with multi-morbidity and adverse drug reactions in older adults

Scutt, G., Overall, A., Bakrania, P., Krasteva, E., Parekh, N., Ali, K., Davies, G. & Rajkumar, C. 2018

Research output: Contribution to conferenceOther

Drug-Related Side Effects and Adverse Reactions
Oxidants
Comorbidity
Morbidity
Pharmaceutical Preparations

Does the 5-HT1A rs6295 polymorphism influence the safetyand efficacy of citalopram therapy in the oldest old?

Scutt, G., Overall, A., Scott, R., Patel, B., Hachoumi, L., Yeoman, M. & Wright, J. 23 Apr 2018 9, 7, p. 355-366

Research output: Contribution to journalArticle

Open Access
File
Citalopram
Genotype
Major Depressive Disorder
Bayes Theorem
Antidepressive Agents

Identification of clinical factors predicting warfarin sensitivity after cardiac surgery

Tyson, K., Hutchinson, N., Williams, S. & Scutt, G. 5 Jun 2018

Research output: Contribution to journalArticle

Open Access
File
Warfarin
Thoracic Surgery
International Normalized Ratio
Stroke Volume
Linear Models

Using simulation to facilitate understanding of medicines

Scutt, G. & Allen, M. 1 Sep 2017 99, 366, p. 85-86 2 p.

Research output: Contribution to journalArticle

Open Access
File
Pharmacists
Patient Care
Learning
Students