• Sensory Neuroscience Research Group, School of Pharmacy and Biomolecular Sciences, Huxley Building, University of Brighton, Lewes Road, Brighton, BN2 4GJ

    United Kingdom

19982020
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Research Output 1998 2019

  • 25 Article
  • 8 Conference contribution with ISSN or ISBN
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Article
2019

Drug diffusion along an intact mammalian cochlea

Sadreev, I. I., Burwood, G. W. S., Flaherty, S. M., Kim, J., Russell, I. J., Abdullin, T. I. & Lukashkin, A. N., 26 Apr 2019, In : Frontiers in Cellular Neuroscience. 13, 161.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Cochlea
Salicylates
Pharmaceutical Preparations
Perilymph
Membranes
2018

Self-assembled nanoformulation of methylprednisolone succinatewith carboxylated block copolymer for local glucocorticoid therapy

Kamalova, M. I., Ðang, T., Petrova, N. V., Laikov, A. V., Luong, D., Akhmadishina, R. A., Lukashkin, A. & Abdullin, T. I., 11 Jan 2018, In : Colloids and Surfaces B: Biointerfaces. 164, p. 78-88 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Methylprednisolone Hemisuccinate
Methylprednisolone
Glucocorticoids
Block copolymers
UCON 50-HB-5100

The Mammalian Ear: Physics and the Principles of Evolution

Manley, G., Lukashkin, A., Simoes, P., Burwood, G. & Russell, I., 1 Mar 2018, In : Acoustics Today. 14, 1, p. 8-16 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Physics
Natural Selection
Physical Laws
Ear

Transgenic Tmc2 expression preserves inner ear hair cells and vestibular function in mice lacking Tmc1

Asai, Y., Pan, B., Nist-Lund, C., Galvin, A., Lukashkin, A. N., Lukashkina, V. A., Chen, T., Zhou, W., Zhu, H., Russell, I. J., Holt, J. R. & Géléoc, G. S. G., 14 Aug 2018, In : Scientific Reports. 8, 1, 12124.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Inner Auditory Hair Cells
Inner Ear
Proteins
Vestibular Hair Cells
Auditory Hair Cells
2017

A connexin30 mutation rescues hearing and reveals roles for gap junctions in cochlear amplification and micromechanics

Lukashkina, V., Levic, S., Lukashkin, A., Strenzke, N. & Russell, I., 21 Feb 2017, In : Nature Communications. 8

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Amplification mode differs along the length of the mouse cochlea as revealed by connexin 26 deletion from specific gap junctions

Lukashkina, V., Yamashita, T., Zuo, J., Lukashkin, A. & Russell, I., 12 Jul 2017, In : Scientific Reports. 7

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Gap Junctions
Cochlea
Outer Auditory Hair Cells
Basilar Membrane
Sensory Receptor Cells

Corrigendum: A connexin30 mutation rescues hearing and reveals roles for gap junctions in cochlear amplification and micromechanics

Lukashkina, V. A., Levic, S., Lukashkin, A. N., Strenzke, N. & Russell, I. J., 21 Mar 2017, In : Nature Communications. 8, 1 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Rippling pattern of distortion product otoacoustic emissions evoked by high-frequency primaries in guinea pigs

Burwood, G., Russell, I. & Lukashkin, A., 11 Aug 2017, In : Journal of the Acoustical Society of America. 142, 2, p. 855-862 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
pig
ripple
product
standing wave
oscillation
2015

Modified protein expression in the tectorial membrane of the cochlea reveals roles for the striated sheet matrix

Jones, G., Elliott, S., Russell, I. & Lukashkin, A., 6 Jan 2015, In : Biophysical Journal. 108, p. 203-210 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Tectorial Membrane
Cochlea
Outer Auditory Hair Cells
Proteins
Deafness
2014

A novel mechanism of cochlear excitation during simultaneous stimulation and pressure relief through the round window

Weddell, T., Yarin, Y. M., Drexl, M., Russell, I., Elliott, S. J. & Lukashkin, A., 6 Apr 2014, In : Interface. 11, 93, p. 1-10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Multiple indices of the 'bounce' phenomenon obtained from the same human ears

Drexl, M., Ueberfuhr, M., Weddell, T., Lukashkin, A., Wiegrebe, L., Krause, E. & Guerkov, R., 28 Feb 2014, In : Journal of the Association for Research in Otolaryngology. 15, 1, p. 57-72 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Tonotopic morphometry of the lamina reticularis of the guinea pig cochlea with associated microstructures and related mechanical implications

Yarin, Y. M., Lukashkin, A., Poznyakovskiy, A. A., Meissner, H., Fleischer, M., Baumgart, J., Richter, C., Kuhlisch, E. & Zahnert, T., 28 Feb 2014, In : Journal of the Association for Research in Otolaryngology. 15, 1, p. 1-11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

Frequency-dependent properties of the tectorial membrane facilitate energy transmission and amplification in the cochlea

Jones, G. P., Lukashkina, V., Russell, I., Elliott, S. J. & Lukashkin, A., 19 Mar 2013, In : Biophysical Journal. 104, 6, p. 1357-1366 10 p.

Research output: Contribution to journalArticleResearchpeer-review

cochlea
membranes
energy
traveling waves
stiffness
2012

A mouse model for human deafness DFNB22 reveals that hearing impairment is due to a loss of inner hair cell stimulation

Lukashkin, A., Legan, P. K., Weddell, T., Lukashkina, V., Goodyear, R. J., Welstead, L. J., Petit, C., Russell, I. & Richardson, G. P., 20 Nov 2012, In : Proceedings of the National Academy of Sciences. 109, 47, p. 19351-19356 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Inner Auditory Hair Cells
Tectorial Membrane
Organ of Corti
Deafness
Hearing Loss
2011

Prestin links extrinsic tuning to neural excitation in the mammalian cochlea

Weddell, T., Mellado-Lagarde, M., Lukashkina, V., Lukashkin, A., Zuo, J. & Russell, I., 27 Sep 2011, In : Current Biology. 21, 18, p. 682-683 2 p.

Research output: Contribution to journalArticleResearchpeer-review

cochlea
hair
tuning
excitation
organs
2010

Multiple roles for the tectorial membrane in the active cochlea

Lukashkin, A., Richardson, G. P. & Russell, I., 1 Jul 2010, In : Hearing Research. 266, 1-2, p. 26-35 10 p.

Research output: Contribution to journalArticleResearchpeer-review

The dynein–tubulin motor powers active oscillations and amplification in the hearing organ of the mosquito

Warren, B., Lukashkin, A. & Russell, I., 7 Jun 2010, In : Proceedings of the Royal Society B-Biological Sciences. 277, 1688, p. 1761-1769 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The vestibular system mediates sensation of low-frequency sounds in mice

Jones, G., Lukashkina, V., Russell, I. & Lukashkin, A., 31 Dec 2010, In : Journal of the Association for Research in Otolaryngology : JARO. 11, 4, p. 725-732 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Cochlea
Otolithic Membrane
Startle Reflex
Acoustics
Hearing
2009

Analysis of the mouse mutant Cloth-ears shows a role for the voltage-gated sodium channel Scn8a in peripheral neural hearing loss

Mackenzie, F. E., Parker, A., Parkinson, N. J., Oliver, P. L., Brooker, D., Underhill, P., Lukashkina, V., Lukashkin, A., Holmes, C. & Brown, S. D. M., 22 Jun 2009, In : Genes Brain and Behavior. 8, 7, p. 699-713 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

Outer hair cell somatic, not hair bundle, motility is the basis of the cochlear amplifier

Mellado Lagarde, M. M., Drexl, M., Lukashkina, V., Lukashkin, A. & Russell, I., 30 May 2008, In : Nature Neuroscience. 11, 7, p. 746-748 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Outer Auditory Hair Cells
Stereocilia
Cochlea
Basilar Membrane

Prestin's role in cochlear frequency tuning and transmission of mechanical responses to neural excitation

Mellado-Lagarde, M., Drexl, M., Lukashkin, A., Zuo, J. & Russell, I., 12 Feb 2008, In : Current Biology. 18, 3, p. 200-202 3 p.

Research output: Contribution to journalArticleResearchpeer-review

cochlea
tuning
mice
hair
vibration

The role of prestin in the generation of electrically evoked otoacoustic emissions in mice

Drexl, M., Mellado Lagarde, M. M., Zuo, J., Lukashkin, A. & Russell, I., 30 Apr 2008, In : Journal of Neurophysiology. 99, 4, p. 1607-1615 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Outer Auditory Hair Cells
Cochlea
Tectorial Membrane
Organ of Corti
Salicylates

The tectorial membrane: one slice of a complex cochlear sandwich

Richardson, G. P., Lukashkin, A. & Russell, I., 31 Oct 2008, In : Current Opinion in Otolaryngology & Head and Neck Surgery. 16, 5, p. 458-464 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

Sharpened cochlear tuning in a mouse with a genetically modified tectorial membrane

Russell, I., Lukashkina, V., Lukashkin, A., Legan, P. K., Goodyear, R. J. & Richardson, G. P., 28 Feb 2007, In : Nature Neuroscience. 10, 2, p. 215-223 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Tectorial Membrane
Cochlea
Basilar Membrane
Outer Auditory Hair Cells
Hearing Loss
1998

A descriptive model of the receptor potential nonlinearities generated by the hair cell mechanoelectrical transducer

Lukashkin, A. & Russell, I., 1 Feb 1998, In : Journal of the Acoustical Society of America. 103, 2, p. 973-980 8 p.

Research output: Contribution to journalArticleResearchpeer-review

hair
transducers
nonlinearity
retarding
cochlea