Projects per year
Personal profile
Research interests
I research in cochlear physiology and biophysics. Cochlear micromechanics, energy production and propagation in the cochlea which makes the cochlea a perfect frequency analyser with enormous dynamic range are my primary research questions. I am involved in research on interaction between different types of cochlear sensory and supporting cell. Understanding of this interaction is a prerequisite for successful treatment of hearing disorders. I study generation and propagation of optoacoustic emissions. Otoacoustic emissions are widely used in clinics for objective assessment of hearing in patients and knowledge of the mechanisms of emission generation is a matter of great importance. I am interested not only in basic mechanisms of hearing but also in applied research which helps to diagnose and cure hearing disorders. My work on novel mechanisms of cochlear excitation through the round window of the cochlea provides theoretical and practical design principles for the development of new types of hearing aids. I am involved in development of methods for drug delivery into the cochlea.
Supervisory Interests
Physiology and biophysics of the mammalian cochlea with focus on cochlear micromechanics and generation of optoacoustic emissions; Hearing impairment as a consequence of genetic mutation, noise and age-related hearing loss; Development of new types of hearing aid and new ways of drug delivery into the cochlea.
Education/Academic qualification
Master
PhD, University of Sussex
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Collaborations and top research areas from the last five years
Projects
- 4 Finished
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Bioengineering devices for the treatment of hearing loss
Lukashkin, A. (PI), Flaherty, S. (CoI), Russell, I. (CoI) & Lukashkina, V. (CoI)
1/10/17 → 30/09/21
Project: Research Councils / Government Depts.
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Amphiphilic polymer-based enhancers for local drugs delivery to the inner ear
Lukashkin, A. (PI), Savina, I. (CoI), Smart, J. (CoI) & Lukashkina, V. (CoI)
1/09/16 → 31/07/18
Project: EU / International
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Amphiphillic polymer-based enhancers for local drugs delivery to the inner ear
Lukashkin, A. (PI)
1/07/16 → 1/07/18
Project: Charities
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Interaction between sensory and supporting cells in the organ of Corti: basis for sensitivity and frequency selectivity of mammalian cochlea
Lukashkin, A. (PI), Russell, I. (PI), Lukashkina, V. (CoI) & Simoes, P. (CoI)
1/09/15 → 31/08/20
Project: Grant
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Local cochlear mechanical responses revealed through outer hair cell receptor potential measurements
Lukashkin, A. N., Russell, I. J. & Rybdylova, O., 15 Jul 2024, In: Biophysical Journal. 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
A Gap-Junction Mutation Reveals That Outer Hair Cell Extracellular Receptor Potentials Drive High-Frequency Cochlear Amplification
Levic, S., Lukashkina, V. A., Simões, P., Lukashkin, A. N. & Russell, I. J., 9 Sept 2022, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 42, 42, p. 7875-7884 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Drug distribution along the cochlea is strongly enhanced by low-frequency round window micro vibrations
Flaherty, S. M., Russell, I. J. & Lukashkin, A. N., 26 Jun 2021, In: Drug Delivery. 28, 1, p. 1312-1320 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Emilin 2 promotes the mechanical gradient of the cochlear basilar membrane and resolution of frequencies in sound
Russell, I. J., Lukashkina, V. A., Levic, S., Cho, Y. W., Lukashkin, A. N., Ng, L. & Forrest, D., 10 Jun 2020, In: Science Advances. 6, 24, eaba2634.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Local Drug Delivery to the Entire Cochlea without Breaching Its Boundaries
Lukashkin, A. N., Sadreev, I. I., Zakharova, N., Russell, I. J. & Yarin, Y. M., 26 Feb 2020, In: iScience. 23, 3, 100945.Research output: Contribution to journal › Article › peer-review
Open AccessFile