• Sensory Neuroscience Research Group, School of Pharmacy and Biomolecular Sciences, Huxley Building, University of Brighton, Lewes Road, Brighton, BN2 4GJ

    United Kingdom

19972020

Research output per year

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Personal profile

Research interests

I research in cochlear physiology and biophysics. Cochlear micromechanics, energy production and propagation in the cochlea which makes the cochlea a perfect frequency analyser with enormous dynamic range are my primary research questions. I am involved in research on interaction between different types of cochlear sensory and supporting cell. Understanding of this interaction is a prerequisite for successful treatment of hearing disorders. I study generation and propagation of optoacoustic emissions. Otoacoustic emissions are widely used in clinics for objective assessment of hearing in patients and knowledge of the mechanisms of emission generation is a matter of great importance. I am interested not only in basic mechanisms of hearing but also in applied research which helps to diagnose and cure hearing disorders. My work on novel mechanisms of cochlear excitation through the round window of the cochlea provides theoretical and practical design principles for the development of new types of hearing aids. I am involved in development of methods for drug delivery into the cochlea.

Supervisory Interests

Physiology and biophysics of the mammalian cochlea with focus on cochlear micromechanics and generation of optoacoustic emissions; Hearing impairment as a consequence of genetic mutation, noise and age-related hearing loss; Development of new types of hearing aid and new ways of drug delivery into the cochlea.

Education/Academic qualification

PhD, University of Sussex

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Projects

Research Output

  • 44 Article
  • 10 Conference contribution with ISSN or ISBN

Emilin 2 promotes the mechanical gradient of the cochlear basilar membrane and resolution of frequencies in sound

Russell, I. J., Lukashkina, V. A., Levic, S., Levic, S., Cho, Y. W., Lukashkin, A. N., Ng, L. & Forrest, D., 10 Jun 2020, In : Science Advances. 6, 24, EABA2634.

Research output: Contribution to journalArticle

Open Access
File
  • Local Drug Delivery to the Entire Cochlea without Breaching Its Boundaries

    Lukashkin, A. N., Sadreev, I. I., Zakharova, N., Russell, I. J. & Yarin, Y. M., 26 Feb 2020, In : iScience. 23, 3, 100945.

    Research output: Contribution to journalArticle

    Open Access
    File
  • Drug diffusion along an intact mammalian cochlea

    Sadreev, I. I., Burwood, G. W. S., Flaherty, S. M., Kim, J., Russell, I. J., Abdullin, T. I. & Lukashkin, A. N., 26 Apr 2019, In : Frontiers in Cellular Neuroscience. 13, 161.

    Research output: Contribution to journalArticle

    Open Access
    File
  • Roles for gap-junctions in cochlear amplification and micromechanics exposed by a conexin 30 mutation

    Lukashkina, V. A., Levic, S., Strenzke, N., Lukashkin, A. N. & Russell, I. J., 31 May 2018, To the Ear and Back Again - Advances in Auditory Biophysics: Proceedings of the 13th Mechanics of Hearing Workshop. American Institute of Physics Inc., Vol. 1965. 100001. (AIP Conference Proceedings; vol. 1965, no. 1).

    Research output: Chapter in Book/Conference proceeding with ISSN or ISBNConference contribution with ISSN or ISBN

    Open Access
    File
  • Self-assembled nanoformulation of methylprednisolone succinatewith carboxylated block copolymer for local glucocorticoid therapy

    Kamalova, M. I., Ðang, T., Petrova, N. V., Laikov, A. V., Luong, D., Akhmadishina, R. A., Lukashkin, A. & Abdullin, T. I., 11 Jan 2018, In : Colloids and Surfaces B: Biointerfaces. 164, p. 78-88 11 p.

    Research output: Contribution to journalArticle

    Open Access
    File