• Sensory Neuroscience Research Group, School of Pharmacy and Biomolecular Sciences, Huxley Building, University of Brighton, Lewes Road, Brighton, BN2 4GJ

    United Kingdom

19982020
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Personal profile

Research interests

I research in cochlear physiology and biophysics. Cochlear micromechanics, energy production and propagation in the cochlea which makes the cochlea a perfect frequency analyser with enormous dynamic range are my primary research questions. I am involved in research on interaction between different types of cochlear sensory and supporting cell. Understanding of this interaction is a prerequisite for successful treatment of hearing disorders. I study generation and propagation of optoacoustic emissions. Otoacoustic emissions are widely used in clinics for objective assessment of hearing in patients and knowledge of the mechanisms of emission generation is a matter of great importance. I am interested not only in basic mechanisms of hearing but also in applied research which helps to diagnose and cure hearing disorders. My work on novel mechanisms of cochlear excitation through the round window of the cochlea provides theoretical and practical design principles for the development of new types of hearing aids. I am involved in development of methods for drug delivery into the cochlea.

Supervisory Interests

Physiology and biophysics of the mammalian cochlea with focus on cochlear micromechanics and generation of optoacoustic emissions; Hearing impairment as a consequence of genetic mutation, noise and age-related hearing loss; Development of new types of hearing aid and new ways of drug delivery into the cochlea.

Education/Academic qualification

PhD, University of Sussex

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  • 2 Similar Profiles
Cochlea Medicine & Life Sciences
Outer Auditory Hair Cells Medicine & Life Sciences
Tectorial Membrane Medicine & Life Sciences
cochlea Physics & Astronomy
Basilar Membrane Medicine & Life Sciences
membranes Physics & Astronomy
hair Physics & Astronomy
Stereocilia Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2015 2020

Research Output 1998 2019

  • 25 Article
  • 8 Conference contribution with ISSN or ISBN

Drug diffusion along an intact mammalian cochlea

Sadreev, I. I., Burwood, G. W. S., Flaherty, S. M., Kim, J., Russell, I. J., Abdullin, T. I. & Lukashkin, A. N., 26 Apr 2019, In : Frontiers in Cellular Neuroscience. 13, 161.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Cochlea
Salicylates
Pharmaceutical Preparations
Perilymph
Membranes

Roles for gap-junctions in cochlear amplification and micromechanics exposed by a conexin 30 mutation

Lukashkina, V. A., Levic, S., Strenzke, N., Lukashkin, A. N. & Russell, I. J., 31 May 2018, To the Ear and Back Again - Advances in Auditory Biophysics: Proceedings of the 13th Mechanics of Hearing Workshop. American Institute of Physics Inc., Vol. 1965. 100001. (AIP Conference Proceedings; vol. 1965, no. 1).

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNConference contribution with ISSN or ISBNResearchpeer-review

Open Access
File
micromechanics
mutations
mice
hair
hearing

Self-assembled nanoformulation of methylprednisolone succinatewith carboxylated block copolymer for local glucocorticoid therapy

Kamalova, M. I., Ðang, T., Petrova, N. V., Laikov, A. V., Luong, D., Akhmadishina, R. A., Lukashkin, A. & Abdullin, T. I., 11 Jan 2018, In : Colloids and Surfaces B: Biointerfaces. 164, p. 78-88 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Methylprednisolone Hemisuccinate
Methylprednisolone
Glucocorticoids
Block copolymers
UCON 50-HB-5100

The Mammalian Ear: Physics and the Principles of Evolution

Manley, G., Lukashkin, A., Simoes, P., Burwood, G. & Russell, I., 1 Mar 2018, In : Acoustics Today. 14, 1, p. 8-16 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Physics
Natural Selection
Physical Laws
Ear

Transgenic Tmc2 expression preserves inner ear hair cells and vestibular function in mice lacking Tmc1

Asai, Y., Pan, B., Nist-Lund, C., Galvin, A., Lukashkin, A. N., Lukashkina, V. A., Chen, T., Zhou, W., Zhu, H., Russell, I. J., Holt, J. R. & Géléoc, G. S. G., 14 Aug 2018, In : Scientific Reports. 8, 1, 12124.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Inner Auditory Hair Cells
Inner Ear
Proteins
Vestibular Hair Cells
Auditory Hair Cells