Projects per year
Personal profile
Research interests
I am a neuroscientist who studies the molecular biology, cellular biology and biophysics of the normal function and dysfunction of the cochlea in relation to its role in hearing and deafness. I have studied cochlear mechanisms involved in echolocation by bats. I also investigate acoustic behaviour and the physiology of the auditory system by mosquitoes.
Scholarly biography
I was in the first cohort of 11+ entry to Chatham Technical School where I became interested in physics and engineering and took Zoology at Chatham Technical College. I went on to study marine biology and physics at Queen Mary College, University of London under the inspirational tutelage of Professors Eric Smith and Gordon Newell. A Commonwealth Studentship in 1964 to study the significance for fishes of underwater noise under the supportive guidance of David Randall at the University of British Columbia began an endless cycle of grant applications that has kept me in continuous research funding to date. On the basis of presenting a paper on the lateral line system at a meeting in New York I was invited by Hans Lissman, the discoverer of electroreception and electro-communication by fishes, to complete my PhD in Cambridge with a research studentship at Trinity Hall. My research was on a multidisciplinary approach to the efferent control of the lateral line system, which enabled me to consult with experts in widely different research fields all of which would now be classified as Neuroscience and who met at the Saturday Club (the foundation of Neuroscience at Cambridge) in an attic above my lab in Zoology. Following completion of my PhD, I won research fellowships at Magdalene and with the SRC (BBSRC) but spent most of my time at the Plymouth Marine lab working together with Barry Roberts on the lateral lines of dogfish and their functional significance during swimming. We were supported by the stimulating discussion, insight and encouragement of the director Eric Denton and Sir John Gray. During this period, I won a Royal Society Research Fellowship to work with Åke Flock on the cellular basis of sensory transduction in lateral line hair cells and its efferent control. The year in Stockholm was an intense and incredibly rewarding period. Åke was a brilliant, imaginative, innovative and very kind person who made the experience productive and enjoyable. Immediately at the end of the year (1970), I took up a lectureship in Neurobiology at the University of Sussex. Possibly the first ever appointment of its kind. The exciting challenge was to be part of the team of biologists and experimental psychologist led by Richard Andrew who designed and initiated the first undergraduate Neurobiology major. Later, I assembled majors in Cognitive Neuroscience, Medical Neuroscience and contributed to Psychology with Neuroscience. Through collaboration with my friend and colleague, Peter Sellick, we defied reason and the BBSRC and made intracellular recordings from sensory cells in the mammalian cochlea. So began research with stimulating and productive colleagues and research students and funded initially from unclaimed prize money from the Reader’s Digest, initiated by the divine intervention of Colin Blakemore, and then largely through programme grants from the MRC and Wellcome Trust which continues at Brighton under the direction of Andrei Lukashkin. Andrei has been pivotal to the research since he joined the lab in 1995 as a remarkable research student who won a Wellcome Prize Studentship in Mathematical Biology to support his DPhil. We continue another line of research on audition and auditory behaviour of mosquitoes begun by chance following a fairly coherent conversation in a pub in Lewes with Gay Gibson, which is overseen by Patricio Simoes who has taken the research in new and exciting directions.
Education/Academic qualification
Fellow of the Royal Society of Biology, Royal Society of Biology
1 Sept 2011 → …
Award Date: 1 Sept 2011
Award of Merit The Association for Research in Otolaryngology , The Association for Research in Otolaryngology
14 Feb 2010 → …
Award Date: 14 Feb 2010
Fellow of the Royal Society, Royal Society
1 May 1989 → …
Award Date: 1 May 1989
Lecturer, Reader, Professor, in Neurobiology, University of Sussex, University of Sussex
1 Jan 1971 → 30 Sept 2011
Award Date: 1 Jan 1971
Research Fellow Magdalene College, Cambridge, SRC Research Fellowship, Roy al Society Travelling Fellowship , University of Cambridge
1 Sept 1969 → 31 Dec 1970
Award Date: 1 Sept 1969
PhD, PhD, Zoology, University of Cambridge, University of Cambridge
30 Sept 1966 → 31 Aug 1969
Award Date: 21 Jun 1969
Master, MSc, Zoology, University of British Columbia, University of British Columbia
1 Sept 1964 → 31 Aug 1966
Award Date: 21 Aug 1966
Bachelor, B Sc, Zoology (Marine Biology), 1st Hons, Queen Mary, University of London , Queen Mary University of London
1 Sept 1961 → 30 Jun 1964
Award Date: 21 Jun 1964
Keywords
- QP Physiology
- Neuroscience
- Hearing
- Cochlea
- Mosquito
- Echolocation
- Deafness
- Auditory behaviour
- QL Zoology
- Marine Biology
- Hearing by fish and amphibia
- Lateral line system
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Collaborations and top research areas from the last five years
Projects
- 2 Finished
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Bioengineering devices for the treatment of hearing loss
Lukashkin, A. (PI), Flaherty, S. (CoI), Russell, I. (CoI) & Lukashkina, V. (CoI)
1/10/17 → 30/09/21
Project: Research Councils / Government Depts.
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Interaction between sensory and supporting cells in the organ of Corti: basis for sensitivity and frequency selectivity of mammalian cochlea
Lukashkin, A. (PI), Russell, I. (PI), Lukashkina, V. (CoI) & Simoes, P. (CoI)
1/09/15 → 31/08/20
Project: Grant
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Local cochlear mechanical responses revealed through outer hair cell receptor potential measurements
Lukashkin, A. N., Russell, I. J. & Rybdylova, O., 15 Jul 2024, In: Biophysical Journal. 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Optogenetics reveals roles for supporting cells in force transmission to and from outer hair cells in the mouse cochlea
Lukashkina, V. A., Levic, S., Simões, P., Xu, Z., Li, Y., Haugen, T., Zuo, J., Lukashin, A. N. & Russell, I. J., 1 Dec 2023, In: The Journal of neuroscience : the official journal of the Society for Neuroscience.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
A Gap-Junction Mutation Reveals That Outer Hair Cell Extracellular Receptor Potentials Drive High-Frequency Cochlear Amplification
Levic, S., Lukashkina, V. A., Simões, P., Lukashkin, A. N. & Russell, I. J., 9 Sept 2022, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 42, 42, p. 7875-7884 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Auditory sensory range of male mosquitoes for the detection of female flight sound
Nakata, T., Simões, P., Walker, S. M., Russell, I. J. & Bomphrey, R. J., 24 Aug 2022, In: Interface. 19, 193, 10 p., 20220285.Research output: Contribution to journal › Article › peer-review
Open Access -
The role of hearing in mosquito behaviour
Feugère, L., Simões, P. M. V., Russell, I. J. & Gibson, G., 22 Dec 2022, Sensory ecology of disease vectors. Ignell, R., Lazzari, C. R. & Hill, S. R. (eds.). Wageningen Academic Publishers, p. 683-708 26 p. (Sensory ecology of disease vectors).Research output: Chapter in Book/Conference proceeding with ISSN or ISBN › Chapter › peer-review
Open Access