Andrei Lukashkin

2024

Local cochlear mechanical responses revealed through outer hair cell receptor potential measurements

Lukashkin, A. N., Russell, I. J. & Rybdylova, O., 15 Jul 2024, In: Biophysical Journal. 123, 18, p. 3163-3175 13 p.

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2022

A Gap-Junction Mutation Reveals That Outer Hair Cell Extracellular Receptor Potentials Drive High-Frequency Cochlear Amplification

Levic, S., Lukashkina, V. A., Simões, P., Lukashkin, A. N. & Russell, I. J., 9 Sept 2022, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 42, 42, p. 7875-7884 9 p.

Research output: Contribution to journal › Article › peer-review

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2021

Drug distribution along the cochlea is strongly enhanced by low-frequency round window micro vibrations

Flaherty, S. M., Russell, I. J. & Lukashkin, A. N., 26 Jun 2021, In: Drug Delivery. 28, 1, p. 1312-1320 9 p.

Research output: Contribution to journal › Article › peer-review

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2020

Emilin 2 promotes the mechanical gradient of the cochlear basilar membrane and resolution of frequencies in sound

Russell, I. J., Lukashkina, V. A., Levic, S., Cho, Y. W., Lukashkin, A. N., Ng, L. & Forrest, D., 10 Jun 2020, In: Science Advances. 6, 24, eaba2634.

Research output: Contribution to journal › Article › peer-review

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Local Drug Delivery to the Entire Cochlea without Breaching Its Boundaries

Lukashkin, A. N., Sadreev, I. I., Zakharova, N., Russell, I. J. & Yarin, Y. M., 26 Feb 2020, In: iScience. 23, 3, 100945.

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2019

Drug Diffusion Along an Intact Mammalian Cochlea

Sadreev, I. I., Burwood, G. W. S., Flaherty, S. M., Kim, J., Russell, I. J., Abdullin, T. I. & Lukashkin, A. N., 26 Apr 2019, In: Frontiers in Cellular Neuroscience. 13, p. 1-11 11 p., 161.

Research output: Contribution to journal › Article › peer-review

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2018

Roles for gap-junctions in cochlear amplification and micromechanics exposed by a conexin 30 mutation

Lukashkina, V. A., Levic, S., Strenzke, N., Lukashkin, A. N. & Russell, I. J., 31 May 2018, To the Ear and Back Again - Advances in Auditory Biophysics: Proceedings of the 13th Mechanics of Hearing Workshop. American Institute of Physics Inc., Vol. 1965. 100001. (AIP Conference Proceedings; vol. 1965, no. 1).

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Self-assembled nanoformulation of methylprednisolone succinatewith carboxylated block copolymer for local glucocorticoid therapy

Kamalova, M. I., Ðang, T., Petrova, N. V., Laikov, A. V., Luong, D., Akhmadishina, R. A., Lukashkin, A. & Abdullin, T. I., 11 Jan 2018, In: Colloids and Surfaces B: Biointerfaces. 164, p. 78-88 11 p.

Research output: Contribution to journal › Article › peer-review

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The Mammalian Ear: Physics and the Principles of Evolution

Manley, G., Lukashkin, A., Simoes, P., Burwood, G. & Russell, I., 1 Mar 2018, In: Acoustics Today. 14, 1, p. 8-16 9 p.

Research output: Contribution to journal › Article › peer-review

Transgenic Tmc2 expression preserves inner ear hair cells and vestibular function in mice lacking Tmc1

Asai, Y., Pan, B., Nist-Lund, C., Galvin, A., Lukashkin, A. N., Lukashkina, V. A., Chen, T., Zhou, W., Zhu, H., Russell, I. J., Holt, J. R. & Géléoc, G. S. G., 14 Aug 2018, In: Scientific Reports. 8, 1, p. 1-15 15 p., 12124.

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2017

A connexin30 mutation rescues hearing and reveals roles for gap junctions in cochlear amplification and micromechanics

Lukashkina, V., Levic, S., Lukashkin, A., Strenzke, N. & Russell, I., 21 Feb 2017, In: Nature Communications. 8, 14530.

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Amplification mode differs along the length of the mouse cochlea as revealed by connexin 26 deletion from specific gap junctions

Lukashkina, V., Yamashita, T., Zuo, J., Lukashkin, A. & Russell, I., 12 Jul 2017, In: Scientific Reports. 7, p. 1-11 11 p., 5185.

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Corrigendum: A connexin30 mutation rescues hearing and reveals roles for gap junctions in cochlear amplification and micromechanics

Lukashkina, V. A., Levic, S., Lukashkin, A. N., Strenzke, N. & Russell, I. J., 21 Mar 2017, In: Nature Communications. 8, 1 p.

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Rippling pattern of distortion product otoacoustic emissions evoked by high-frequency primaries in guinea pigs

Burwood, G., Russell, I. & Lukashkin, A., 11 Aug 2017, In: Journal of the Acoustical Society of America. 142, 2, p. 855-862 8 p.

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2016

Cochlear excitation by the near-field component during stimulation through the partially occluded round window

Weddell, T. D., Yarin, Y. M., Drexl, M., Russell, I. J., Elliott, S. J. & Lukashkin, A. N., 15 Jan 2016, Mechanics of Hearing: Protein to Perception - Proceedings of the 12th International Workshop on the Mechanics of Hearing. American Institute of Physics Inc., Vol. 1703. 060019

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Efficient energy transmission and amplification in the cochlea relies on frequency-dependent material properties of the tectorial membrane

Jones, G. P., Lukashkina, V. A., Russell, I. J., Elliott, S. J. & Lukashkin, A. N., 15 Jan 2016, Mechanics of Hearing: Protein to Perception - Proceedings of the 12th International Workshop on the Mechanics of Hearing. American Institute of Physics Inc., Vol. 1703. 080002

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2015

Modified Protein Expression in the Tectorial Membrane of the Cochlea Reveals Roles for the Striated Sheet Matrix

Jones, G., Elliott, S., Russell, I. & Lukashkin, A., 6 Jan 2015, In: Biophysical Journal. 108, 1, p. 203-210 8 p.

Research output: Contribution to journal › Article › peer-review

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2014

A novel mechanism of cochlear excitation during simultaneous stimulation and pressure relief through the round window

Weddell, T., Yarin, Y. M., Drexl, M., Russell, I., Elliott, S. J. & Lukashkin, A., 6 Apr 2014, In: Interface. 11, 93, p. 1-10 10 p.

Research output: Contribution to journal › Article › peer-review

Multiple indices of the 'bounce' phenomenon obtained from the same human ears

Drexl, M., Ueberfuhr, M., Weddell, T., Lukashkin, A., Wiegrebe, L., Krause, E. & Guerkov, R., 28 Feb 2014, In: Journal of the Association for Research in Otolaryngology. 15, 1, p. 57-72 16 p.

Research output: Contribution to journal › Article › peer-review

Tonotopic morphometry of the lamina reticularis of the guinea pig cochlea with associated microstructures and related mechanical implications

Yarin, Y. M., Lukashkin, A., Poznyakovskiy, A. A., Meissner, H., Fleischer, M., Baumgart, J., Richter, C., Kuhlisch, E. & Zahnert, T., 28 Feb 2014, In: Journal of the Association for Research in Otolaryngology. 15, 1, p. 1-11 11 p.

Research output: Contribution to journal › Article › peer-review

2013

Frequency-dependent properties of the tectorial membrane facilitate energy transmission and amplification in the cochlea

Jones, G. P., Lukashkina, V., Russell, I., Elliott, S. J. & Lukashkin, A., 19 Mar 2013, In: Biophysical Journal. 104, 6, p. 1357-1366 10 p.

Research output: Contribution to journal › Article › peer-review

2012

A mouse model for human deafness DFNB22 reveals that hearing impairment is due to a loss of inner hair cell stimulation

Lukashkin, A., Legan, P. K., Weddell, T., Lukashkina, V., Goodyear, R. J., Welstead, L. J., Petit, C., Russell, I. & Richardson, G. P., 20 Nov 2012, In: Proceedings of the National Academy of Sciences. 109, 47, p. 19351-19356 6 p.

Research output: Contribution to journal › Article › peer-review

2011

Basilar membrane measurements from wild type, prestin 499, and prestin KO mice

Weddell, T., Mellado-Lagarde, M., Lukashkina, V., Lukashkin, A., Zuo, J. & Russell, I., 12 Dec 2011, What Fire is in Mine Ears: Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop. p. 432-433 2 p. (AIP Conference Proceedings; vol. 1403).

Research output: Chapter in Book/Conference proceeding with ISSN or ISBN › Conference contribution with ISSN or ISBN › peer-review

Laser interferometer measurements of the viscoelastic properties of tectorial membrane mutants

Jones, G., Russell, I. & Lukashkin, A., 12 Dec 2011, What Fire is in Mine Ears: Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop. p. 419-420 2 p. (AIP Conference Proceedings; vol. 1403).

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Mechanisms of cochlear stimulation through the round window

Lukashkin, A. N., Weddell, T. & Russell, I. J., 12 Dec 2011, What Fire is in Mine Ears: Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop. Vol. 1403. p. 421-422 2 p.

Research output: Chapter in Book/Conference proceeding with ISSN or ISBN › Conference contribution with ISSN or ISBN › peer-review

Otoancorin knockout mice reveal inertia is the force for hearing

Weddell, T., Legan, P. K., Lukashkina, V. A., Goodyear, R. J., Welstead, L., Petit, C., Russell, I. J., Lukashkin, A. N. & Richardson, G. P., 12 Dec 2011, What Fire is in Mine Ears: Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop. Vol. 1403. p. 139-140 2 p.

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Prestin links extrinsic tuning to neural excitation in the mammalian cochlea

Weddell, T., Mellado-Lagarde, M., Lukashkina, V., Lukashkin, A., Zuo, J. & Russell, I., 27 Sept 2011, In: Current Biology. 21, 18, p. 682-683 2 p.

Research output: Contribution to journal › Article › peer-review

2010

Multiple roles for the tectorial membrane in the active cochlea

Lukashkin, A., Richardson, G. P. & Russell, I., 1 Jul 2010, In: Hearing Research. 266, 1-2, p. 26-35 10 p.

Research output: Contribution to journal › Article › peer-review

The dynein–tubulin motor powers active oscillations and amplification in the hearing organ of the mosquito

Warren, B., Lukashkin, A. & Russell, I., 7 Jun 2010, In: Proceedings of the Royal Society B-Biological Sciences. 277, 1688, p. 1761-1769 9 p.

Research output: Contribution to journal › Article › peer-review

The vestibular system mediates sensation of low-frequency sounds in mice

Jones, G., Lukashkina, V., Russell, I. & Lukashkin, A., 31 Dec 2010, In: Journal of the Association for Research in Otolaryngology : JARO. 11, 4, p. 725-732 8 p.

Research output: Contribution to journal › Article › peer-review

2009

Analysis of the mouse mutant Cloth-ears shows a role for the voltage-gated sodium channel Scn8a in peripheral neural hearing loss

Mackenzie, F. E., Parker, A., Parkinson, N. J., Oliver, P. L., Brooker, D., Underhill, P., Lukashkina, V., Lukashkin, A., Holmes, C. & Brown, S. D. M., 22 Jun 2009, In: Genes Brain and Behavior. 8, 7, p. 699-713 15 p.

Research output: Contribution to journal › Article › peer-review

2008

Determining the identity of the cochlear amplifier: Electrical stimulation of the tecta mouse cochlea

Mellado Lagarde, M. M., Drexl, M., Lukashkina, V. A., Lukashkin, A. N. & Russell, I. J., 1 Jan 2008, Concepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008. Kemp, D. T. & Cooper, N. P. (eds.). World Scientific Publishing Co. Pte Ltd, p. 106-112 7 p. (Concepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008).

Research output: Chapter in Book/Conference proceeding with ISSN or ISBN › Conference contribution with ISSN or ISBN › peer-review

Does the cochlea compromise on sensitivity and frequency selectivity?

Lukashkin, A. N., Lukashkina, V. A., Richardson, G. P. & Russell, I. J., 1 Jan 2008, Concepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008. Kemp, D. T. & Cooper, N. P. (eds.). World Scientific Publishing Co. Pte Ltd, p. 141-147 7 p. (Concepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008).

Research output: Chapter in Book/Conference proceeding with ISSN or ISBN › Conference contribution with ISSN or ISBN › peer-review

Novel roles for prestin in frequency tuning and neural excitation in the mouse cochlea

Mellado Lagarde, M. M., Drexl, M., Lukashkin, A. N., Zuo, J. & Russell, I. J., 1 Jan 2008, Concepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008. Kemp, D. T. & Cooper, N. P. (eds.). World Scientific Publishing Co. Pte Ltd, p. 148-154 7 p. (Concepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008).

Research output: Chapter in Book/Conference proceeding with ISSN or ISBN › Conference contribution with ISSN or ISBN › peer-review

2007

Power Amplification in the Mammalian Cochlea

Lukashkin, A. N., Walling, M. N. & Russell, I. J., 7 Aug 2007, In: Current Biology. 17, 15, p. 1340-1344 5 p.

Research output: Contribution to journal › Article › peer-review

Properties of distortion product otoacoustic emissions and neural suppression tuning curves attributable to the tectorial membrane resonance

Lukashkin, A. N., Smith, J. K. & Russell, I. J., 22 Jan 2007, In: Journal of the Acoustical Society of America. 121, 1, p. 337-343 7 p.

Research output: Contribution to journal › Article › peer-review

Sharpened cochlear tuning in a mouse with a genetically modified tectorial membrane

Russell, I., Lukashkina, V., Lukashkin, A., Legan, P. K., Goodyear, R. J. & Richardson, G. P., 28 Feb 2007, In: Nature Neuroscience. 10, 2, p. 215-223 9 p.

Research output: Contribution to journal › Article › peer-review

2005

2004

Role of the Tectorial Membrane Revealed by Otoacoustic Emissions Recorded from Wild-Type and Transgenic Tecta^ΔENT/ΔENT Mice

Lukashkin, A. N., Lukashkina, V. A., Legan, P. K., Richardson, G. P. & Russell, I. J., 1 Jan 2004, In: Journal of Neurophysiology. 91, 1, p. 163-171 9 p.

Research output: Contribution to journal › Article › peer-review