A deafness mutation isolates a second role for the tectorial membrane in hearing

P. Kevin Legan, Victoria A. Lukashkina, Richard J. Goodyear, Andrei N. Lukashkin, Kristien Verhoeven, Guy Van Camp, Ian J. Russell, Guy P. Richardson

    Research output: Contribution to journalArticlepeer-review


    α-tectorin (encoded by Tecta) is a component of the tectorial membrane, an extracellular matrix of the cochlea. In humans, the Y1870C missense mutation in TECTA causes a 50- to 80-dB hearing loss. In transgenic mice with the Y1870C mutation in Tecta, the tectorial membrane's matrix structure is disrupted, and its adhesion zone is reduced in thickness. These abnormalities do not seriously influence the tectorial membrane's known role in ensuring that cochlear feedback is optimal, because the sensitivity and frequency tuning of the mechanical responses of the cochlea are little changed. However, neural thresholds are elevated, neural tuning is broadened, and a sharp decrease in sensitivity is seen at the tip of the neural tuning curve. Thus, using TectaY1870C/+ mice, we have genetically isolated a second major role for the tectorial membrane in hearing: it enables the motion of the basilar membrane to optimally drive the inner hair cells at their best frequency.

    Original languageEnglish
    Pages (from-to)1035-1042
    Number of pages8
    JournalNature Neuroscience
    Issue number8
    Publication statusPublished - 1 Aug 2005


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