Outer hair cell somatic, not hair bundle, motility is the basis of the cochlear amplifier

M.M. Mellado Lagarde, M. Drexl, Victoria Lukashkina, Andrei Lukashkin, Ian Russell

Research output: Contribution to journalArticle

Abstract

Sensitivity, dynamic range and frequency tuning of the cochlea are attributed to amplification involving outer hair cell stereocilia and/or somatic motility. We measured acoustically and electrically elicited basilar membrane displacements from the cochleae of wild-type and TectaENT/ENT mice, in which stereocilia are unable to contribute to amplification near threshold. Electrically elicited responses from TectaENT/ENT mice were markedly similar to acoustically and electrically elicited responses from wild-type mice. We conclude that somatic, and not stereocilia, motility is the basis of cochlear amplification.
Original languageEnglish
Pages (from-to)746-748
Number of pages3
JournalNature Neuroscience
Volume11
Issue number7
DOIs
Publication statusPublished - 30 May 2008

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