TY - JOUR
T1 - Outer hair cell somatic, not hair bundle, motility is the basis of the cochlear amplifier
AU - Mellado Lagarde, M.M.
AU - Drexl, M.
AU - Lukashkina, Victoria
AU - Lukashkin, Andrei
AU - Russell, Ian
PY - 2008/5/30
Y1 - 2008/5/30
N2 - Sensitivity, dynamic range and frequency tuning of the cochlea are attributed to amplification involving outer hair cell stereocilia and/or somatic motility. We measured acoustically and electrically elicited basilar membrane displacements from the cochleae of wild-type and TectaENT/ENT mice, in which stereocilia are unable to contribute to amplification near threshold. Electrically elicited responses from TectaENT/ENT mice were markedly similar to acoustically and electrically elicited responses from wild-type mice. We conclude that somatic, and not stereocilia, motility is the basis of cochlear amplification.
AB - Sensitivity, dynamic range and frequency tuning of the cochlea are attributed to amplification involving outer hair cell stereocilia and/or somatic motility. We measured acoustically and electrically elicited basilar membrane displacements from the cochleae of wild-type and TectaENT/ENT mice, in which stereocilia are unable to contribute to amplification near threshold. Electrically elicited responses from TectaENT/ENT mice were markedly similar to acoustically and electrically elicited responses from wild-type mice. We conclude that somatic, and not stereocilia, motility is the basis of cochlear amplification.
U2 - 10.1038/nn.2129
DO - 10.1038/nn.2129
M3 - Article
SN - 1097-6256
VL - 11
SP - 746
EP - 748
JO - Nature Neuroscience
JF - Nature Neuroscience
IS - 7
ER -