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Research Output 1998 2019

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2018

An overview of anti-diabetic plants used in Gabon: Pharmacology and toxicology

Bading Taika, B., Bouckandou, M., Souza, A., Bourobou Bourobou, H. P., Mackenzie, L. & Lione, L. A., 2 Jan 2018, In : Journal of Ethnopharmacology. 216, p. 203-228 26 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Gabon
Toxicology
Pharmacology
Hyperglycemia
Tabernaemontana

The non-genomic effects of the PPARβ/δ agonist GW0742 on STZ treated rat aorta

Perez-Diaz, N., Pushkarsky, I., Oweis, N., Lione, L. A. & Mackenzie, L., 31 Dec 2018, In : Current Molecular Pharmacology. 11, 2, p. 149-154 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Peroxisome Proliferator-Activated Receptors
Aorta
Dilatation
GW0742
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
2016

A New NO-Releasing Nanoformulation for the Treatment of Pulmonary Arterial Hypertension

Mohamed, N. A., Ahmetaj-Shala, B., Duluc, L., Mackenzie, L., Kirkby, N. S., Reed, D. M., Lickiss, P. D., Davies, R. P., Freeman, G. & Wojciak-Stothard, B., 9 Mar 2016, In : Journal of Cardiovascular Translational Research. 9, 2, p. 162-164 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Pulmonary Hypertension
Nitric Oxide
Nanomedicine
Hydrogel
Half-Life

Evidence that Diclofenac and Celecoxib are thyroid hormone receptor beta antagonists

Zloh, M., Perez-Diaz, N., Tang, L., Patel, P. & Mackenzie, L., 1 Feb 2016, In : Life Sciences. 146, p. 66-72 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Celecoxib
Thyroid Hormone Receptors beta
Diclofenac
Naproxen
Non-Steroidal Anti-Inflammatory Agents

Methylglyoxal, A Metabolite Increased in Diabetes is Associated with InsulinResistance, Vascular Dysfunction and Neuropathies

Shamsaldeen, Y. A., Mackenzie, L., Lione, L. A. & Benham, C. D., 1 Jan 2016, In : Current Drug Metabolism. 17, 4, p. 359-367 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Pyruvaldehyde
Blood Vessels
Diabetes Complications
Hyperglycemia
Bibliographic Databases
2015

Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: novel explanation of cardiovascular side effects associated with anti-inflammatory drugs

Ahmetaj-Shala, B., Kirkby, N. S., Knowles, R., Al’Yamani, M., Mazi, S., Wang, Z., Tucker, A. T., Mackenzie, L., Armstrong, P. C. J. & Nusing, R. M., 27 Oct 2015, In : Circulation. 131, 7, p. 633-642 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Cyclooxygenase 2
Anti-Inflammatory Agents
Kidney
omega-N-Methylarginine
Biomarkers

In silico modelling of prostacyclin and other lipid mediators to nuclear receptors reveal novel thyroid hormone receptor antagonist properties

Perez-Diaz, N., Zloh, M., Patel, P. & Mackenzie, L., 11 Dec 2015, In : Prostaglandins & Other Lipid Mediators. 122, p. 18-27 10 p.

Research output: Contribution to journalArticleResearchpeer-review

beraprost
Hormone Antagonists
Thyroid Hormone Receptors
Epoprostenol
Cytoplasmic and Nuclear Receptors

Linking Induction and Transrepression of PPARβ/δ with Cellular Function

Perez-Diaz, N. & Mackenzie, L., 26 Jan 2015, In : Annual Research and Review in Biology. 6, 4, p. 253-263 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Peroxisome Proliferator-Activated Receptors
Cytoplasmic and Nuclear Receptors
Ligands
Drug and Narcotic Control
Drug Design

Reply to Letter Regarding Article, "Evidence That Links Loss of Cyclooxygenase-2 With Increased Asymmetric Dimethylarginine: Novel Explanation of Cardiovascular Side Effects Associated With Anti-Inflammatory Drugs

Ahmetaj-Shala, B., Kirkby, N. S., Knowles, R., Al’Yamani, M., Mazi, S., Wang, Z., Tucker, A. T., Mackenzie, L., Armstrong, P. C. J. & Nusing, R. M., 24 Nov 2015, In : Circulation. 132, 17, p. 213-214 2 p.

Research output: Contribution to journalArticleResearch

2014

Role of prostacyclin in pulmonary hypertension

Mitchell, J., Ahmetaj-Shala, B., Kirkby, N. S., Wright, W. R., Mackenzie, L., Reed, D. M. & Mohamed, N. A., 31 Dec 2014, In : Global Cardiology Science and Practice. 4, p. 382-393 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Epoprostenol
Pulmonary Hypertension
Lung
Epoprostenol Receptors
Hormones

Selective inhibition of NADPH Oxidase reverses the over contraction of diabetic rat aorta

Rehman, A. U., Dugic, E., Benham, C. D., Lione, L. A. & Mackenzie, L., 1 Jan 2014, In : Redox Biology. 2, p. 61-64 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
NADPH Oxidase
Aorta
Phenylephrine
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Reactive Oxygen Species
2013

Aspirin triggered 15-epi-lipoxin A4 predicts cyclo-oxygenase-2 in the lungs of LPS treated mice but not in the circulation: implications for a clinical test

Kirkby, N. S., Chan, M., Lundberg, M. H., Massey, K. A., Edmands, W. M. B., Mackenzie, L., Holmes, E., Nicolaou, A., Warner, T. D. & Mitchell, J., 1 Jun 2013, In : Faseb journal. 27, 10, p. 3938-3946 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Prostaglandin-Endoperoxide Synthases
Aspirin
Cyclooxygenase 2
Lipoxins
Lung

Cross-talk between toll-like receptor 4 (TLR4) and proteinase-activated receptor 2 (PAR) is involved in vascular function

Bucci, M., Vellecco, V., Harrington, L., Brancaleone, V., Roviezzo, F., Mattace Raso, G., Ianaro, A., Lungarella, G., De Palma, R. & Meli, R., 1 Jan 2013, In : British Journal of Pharmacology. 168, 2, p. 411-420 10 p.

Research output: Contribution to journalArticleResearchpeer-review

PAR-2 Receptor
Toll-Like Receptor 4
Blood Vessels
Peptides
Vasodilation

Harnessing the benefits of PPARβ/δ agonists

Mackenzie, L. & Lione, L. A., 18 Dec 2013, In : Life Sciences. 93, 25-26, p. 963-967 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Peroxisome Proliferator-Activated Receptors
Mediator Complex
Clinical Trials
Lipids
Research

LC-MS/MS Confirms That COX-1 Drives Vascular Prostacyclin Whilst Gene Expression Pattern Reveals Non-Vascular Sites of COX-2 Expression

Kirkby, N. S., Zaiss, A. K., Urquhart, P., Jiao, J., Austin, P. J., Al’Yamani, M., Lundberg, M. H., Mackenzie, L., Warner, T. D. & Nicolaou, A., 9 Jul 2013, In : PLoS ONE. 8, 7

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Cyclooxygenase 1
Epoprostenol
Cyclooxygenase 2
Blood Vessels
Gene Expression

Linking phospholipase C isoforms with differentiation function in human vascular smooth muscle cells

Mackenzie, L., Lymn, J. S. & Hughes, A. D., 14 Aug 2013, In : BBA - Molecular Cell Research. 1833, 12, p. 3006-3012 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Type C Phospholipases
Vascular Smooth Muscle
Smooth Muscle Myocytes
Protein Isoforms
Actins
2012

Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system

Kirkby, N. S., Lundberg, M. H., Harrington, L., Leadbeater, P. D. M., Milne, G., Potter, C. M. F., Al’Yamani, M., Adeyemi, O., Warner, T. D. & Mitchell, J., 23 Oct 2012, In : Proceedings of the National Academy of Sciences. 109, 43, p. 17597-17602 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Cyclooxygenase 1
Epoprostenol
Cyclooxygenase 2
Cardiovascular System
Endothelium

Role of RhoB in the regulation of pulmonary endothelial and smooth muscle cell responses to hypoxia

Wojciak-Stothard, B., Zhao, L., Oliver, E., Dubois, O., Wu, Y., Kardassis, D., Vasilaki, E., Huang, M., Mitchell, J. & Harrington, L., 25 May 2012, In : Circulation Research. 110, 11, p. 1423-1434 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Smooth Muscle Myocytes
Lung
Pulmonary Hypertension
Farnesyltranstransferase
Blood Vessels
2011

Reduced endothelial dependent vasodilation in vessels from TLR4 mice is associated with increased superoxide generation

Harrington, L., Lundberg, M. H., Waight, M., Rozario, A. & Mitchell, J., 20 May 2011, In : Biochemical and biophysical research communications. 408, 4, p. 511-515 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Vasodilation
Superoxides
Mesenteric Arteries
Toll-Like Receptor 4
Vasodilator Agents

Role of shear stress in endothelial cell morphology and expression of cyclooxygenase isoforms

Potter, C. M. F., Lundberg, M. H., Harrington, L., Warboys, C. M., Warner, T. D., Berson, R. E., Moshkov, A. V., Gorelik, J., Weinburg, P. D. & Mitchell, J., 1 Feb 2011, In : Arteriosclerosis Thrombosis and Vascular Biology. 31, 2, p. 384-391 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Cyclooxygenase 1
Prostaglandin-Endoperoxide Synthases
Protein Isoforms
Cyclooxygenase 2
Endothelial Cells
2010

Nucleotide oligomerization domain 1 is a dominant pathway for NOS2 induction in vascular smooth muscle cells: comparison with Toll-like receptor 4 responses in macrophages

Moreno, L., McMaster, S. K., Gatheral, T., Harrington, L., Cartwright, N., Armstrong, P. C. J., Warner, T. D., Paul-Clark, M. & Mitchell, J., 1 Aug 2010, In : British Journal of Pharmacology. 160, p. 1997-2007 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Toll-Like Receptor 4
Vascular Smooth Muscle
Smooth Muscle Myocytes
Nucleotides
Macrophages

The PPARβ/δ agonist GW0742 relaxes pulmonary vessels and limits right heart hypertrophy in rats with hypoxia-induced pulmonary hypertension

Harrington, L., Moreno, L., Reed, A., Wort, S. J., Desvergne, B., Garland, C., Zhao, L. & Mitchell, J., 4 Mar 2010, In : PLoS ONE. 5, 3

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Peroxisome Proliferator-Activated Receptors
PPAR-beta
Cardiomegaly
Pulmonary Hypertension
Lung
2008

COX-1, and not COX-2 activity, regulates airway function: Relevance to aspirin-sensitive asthma

Mackenzie, L., Lucas, R., McMaster, S. K., Moreno, L., Scalding, G., Warner, T. D. & Mitchell, J., 27 Aug 2008, In : Faseb journal. 22, 11, p. 4005-4010 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Cyclooxygenase 1
Cyclooxygenase 2
Aspirin
Asthma
Cyclooxygenase 2 Inhibitors

Evidence for a specific influence of the nitrergic pathway on the peripheral pulse waveform in rabbits

Nier, B. A., Harrington, L., Carrier, M. J. & Weinberg, P. D., 25 Jan 2008, In : Experimental Physiology. 93, 4, p. 503-512 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Pulse
Nitric Oxide
NG-Nitroarginine Methyl Ester
Rabbits
Phentolamine

Role of nitric oxide and prostacyclin as vasoactive hormones released by the endothelium

Mitchell, J., Ali, F., Bailey, L., Moreno, L. & Harrington, L., 1 Jan 2008, In : Experimental Physiology. 93, 1, p. 141-147 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Epoprostenol
Endothelium
Nitric Oxide
Hormones
Blood Vessels
2007

Elucidation of the temporal relationship between endothelial-derived NO and EDHF in mesenteric vessels

Harrington, L., Carrier, M. J., Gallagher, N., Gilroy, D., Garland, C. J. & Mitchell, J., 1 Sep 2007, In : American Journal of Physiology-Heart and Circulatory Physiology. 293, 3, p. 1682-1688 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Endothelium
Nitric Oxide
Apamin
Acetylcholine
NG-Nitroarginine Methyl Ester

Homeostatic role of toll-like receptor 4 in the endothelium and heart

Harrington, L., Belcher, E., Moreno, L., Carrier, M. J. & Mitchell, J., 1 Dec 2007, In : Journal Of Cardiovascular Pharmacology And Therapeutics. 12, 4, p. 322-326 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Toll-Like Receptor 4
Endothelium
Dilatation
Acetylcholine
Pattern Recognition Receptors

Purinergic 2X1 Receptors Mediate Endothelial Dependent Vasodilation to ATP

Harrington, L. S., Evans, R. J., Wray, J., Norling, L., Swales, K. E., Vial, C., Ali, F., Carrier, M. J. & Mitchell, J. A., 1 Nov 2007, In : Molecular Pharmacology. 72, 5, p. 1132-1136

Research output: Contribution to journalArticleResearchpeer-review

Purinergic Receptors
Vasodilation
Adenosine Triphosphate
Purinergic P2X1 Receptors
Endothelial Cells
2006

Pharmacology of airways and vessels in lung slices in situ: Role of endogenous dilator hormones

Moreno, L., Perez-Vizcaino, F., Harrington, L., Faro, R., Sturton, G., Barnes, P. J. & Mitchell, J., 21 Aug 2006, In : Respiratory Research. 7, 1, p. 111-118 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Charybdotoxin
Apamin
Hormones
Pharmacology
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
2005

P2X receptors and the endothelium

Harrington, L. & Mitchell, J., 1 Mar 2005, In : Memórias Do Instituto Oswaldo Cruz. 100, p. 111-112 2 p.

Research output: Contribution to journalArticleResearchpeer-review

Purinergic P2X1 Receptors
Endothelium
Adenosine Triphosphate
Arteries
Smooth Muscle Myocytes
2004

Not so EEZE: the ‘EDHF’ antagonist 14, 15 epoxyeicosa-5(Z)-enoic acid has vasodilator properties in mesenteric arteries

Harrington, L. S., Falck, J. R. & Mitchell, J. A., 15 Dec 2004, In : European Journal of Pharmacology. 506, 2, p. 165-168

Research output: Contribution to journalArticleResearchpeer-review

Mesenteric Arteries
Vasodilator Agents
Acids
Methoxamine
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid

Novel role for P2X receptor activation in endothelium-dependent vasodilation

Harrington, L. S. & Mitchell, J. A., 1 Nov 2004, In : British Journal of Pharmacology. 143, 5, p. 611-617

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Vasodilation
Endothelium
Adenosine Triphosphate
Purinergic P2X1 Receptors
Mesenteric Arteries
2000

Coordinate Regulation of Metabolic Enzyme Encoding Genes During Cardiac Development and Following Carvedilol Therapy in Spontaneously Hypertensive Rats

Sack, M. N., Harrington, L. S., Jonassen, A. K. & Yello, D. M., 1 Feb 2000, In : Cardiovascular Drugs and Therapy. 14, 1, p. 31-39

Research output: Contribution to journalArticleResearchpeer-review

Cardiomegaly
Inbred SHR Rats
Fatty Acids
Enzymes
Genes
1998

Refined Genetic Mapping of the Darier Locus to a !1-cM Region of Chromosome 12q24.1, and Construction of a Complete, High-Resolution P1 Artificial Chromosome/Bacterial Artificial Chromosome Contig of the Critical Region

Sakuntabhai, A., Monk, S., Carter, S. A., Bryce, S. D., Cox, R., Harrington, L., Levy, E., Ruiz-Perez, V. L., Katsantoni, E., Kodvawala, A., Munro, C. S., Burge, S., Larrègue, M., Nagy, G., Rees, J. L., Lathrop, M., Monaco, A. P., Strachan, T. & Hovnanian, A., 22 Jan 1998, In : American Journal of Human Genetics. 62, 4, p. 890-903

Research output: Contribution to journalArticleResearchpeer-review

Open Access
chromosome
skin disorder
gene
recombination
clone