Yousif Shamsaldeen
20162021

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Personal profile

Research interests

I have in-depth experience in a wide range of research areas in the field of pharmacology, molecular medicine and pharmacy including endothelial ion channels and vascular dysfunction in diabetes; atrial fibrillation and identifying novel ion channels as therapeutic targets as well as identifying noval proteins for cardiomyopathy; understanding the molecular pathophysiology of age-related macular degeneration and identifying novel therapeutic targets. Moreover, I have excellent experience in clinical research including clinical toxicology and paediatric medicine. 

 

Such research activities involve a wide range of skills including isolating primary cells; cell culturing; electrophysiology; calcium imaging; confocal microscopy: proximity ligation assay and immunocytochemistry; Western blotting and ELISA. In addition to preclinical skills, I have excellent clinical research skills exemplified by publishing retrospective data analysis and case studies.

 

As a lecturer in pharmacology, I intend to establish my research activities at the University of Brighton, and I aim to collaborate with national and international research teams.

Scholarly biography

Dr Yousif Shamsaldeen is a Lecturer in Pharmacology.  His research interests focus on cardiovascular pharmacology, retinopathy, and stem cells.

Dr Shamsaldeen's interests in pharmacology began at Ajman University (UAE) where he studied for a Bachelor in Pharmacy. His final year project researched the pharmacology of botulinum toxin A in managing preipheral symptoms of Parkinson's Disease. In 2011, he moved to the University of Hertfordshire (UK) to study MSc in Pharmacology where he studied molecular medicine; core molecular biology; core pharmacology; molecular pharmacology and drug discovery; in addition to his research project on cardiomyocytes differentiation from P19 stem cells.

 

He then was offered to study PhD (2013-2016) in Pharmacology at the University of Hertfordshire under the suprtvision of Dr Christopher Benham and Dr Lisa Lione. Whilst studying for PhD, he he was offered a job as a visiting lecturer at the University of Hertfordshire (2013-2017). His PhD was carried out partly at Professor Stuart Bevan's research lab at King's College London. Dr Shamsaldeen's PhD project was focusing on endothelial dysfunction in diabetes through which he examined the effect of diabetes on the function of endothelial TRPV4 calcium channel and the related vasodilatory pathways.

 

In 2016, he obtained a post-doctoral position at the University of Bath researching the molecular pathophysiology in age-related macular degeneration working with Dr Amanda Mackenzie and Dr Malcolm Watson. Such a shift from Hertfordshire to Bath and from vascular pharmacology to retinal pharmacology supports his confidence in working in different fields and at different institutes. 

 

In 2017, he was offered a senior postdoctoral research position at the Bristol University where his work examined the effect of different SKCa channel blockers on the eletrophysiology of human primary atrial myocytes -in collaboration with Bristol Heart Institute: Professor Raimondo Ascione- , aiming for identifying potential therapeutic targets for atrial fibrillation through a BHF-funded project. He was working under the management of Professor Neil Marrion, Professor Jules Hancox and Dr Andrew James.

 

In 2020, during the COVID-19 pandemic, Dr Shamsaldeen's returned to the clinic where he worked as a hospital pharmacist in Kuwait where he worked in two hospitals in parallel. He worked with a wide range of helathcare from paediatrics to geriatrics. In addition to providing inpatient, outpatient and casualty care, he trained and mentored pharmacy students and junior phramacists, as well as being a member of antimicrobial stewardship. 

 

In 2021, Dr Shamsaldeen returned to the UK where he was offered a postdoctoral research position at St. George's University of London working with Professor Anthony Albert. His BHF-funded research was about investigating novel proteins and calcium channels for the management of cardiomyopathy applying his extensive experience in pharmacology and electrophysiology to obtain novel findings for further funding. 

 

In October 2022, Dr Shamdaldeen has joined the Unviersity of Brighton as a Lecturer in Pharmacology teaching MPharm course and aiming to establish his research covering a wide range of research activities that he has gained through his extensive academic, clinical and preclinical career.

Approach to teaching

I teach on a wide variety of courses including the four-year MPharm degree and the five-year medical degree.

 

My teaching aims to make pharmacology understandable, joyful and applicable to clinical practice. I teach through allowing students to understand the three cornerstones: physiology, pathophysiology and pharmacology. I aim to simplify the cellular signalling and making it relevant to observed signs and symptoms as well as drugs' effects.

 

Much of my lecture material is based on visual explanation where I design 2D animations and videos. I apply a wide range of student engagement approches such as interactive questions and formative quizes after each series of lectures.

 

In addition to teaching, I supervise and support my students to participate in research to support their future career through publishing research papers and participating in national and international conferences.

Supervisory Interests

My research interests cover a wide range of fields. I am interested in how calcium channels are involved in regulating cardiovscular homeostasis and how age-related and inflammatory changes (such as diabetes) contribute  to vascular dysfunction, cardiomyopathy as well as retinopathy.

 

Additionally, my clinical research interest covers pharmacy practice and clinical toxicology.

 

My groups work uses a systems biology approach to study the effects of chronic diseases and inflammation on ion channels activities. Moreover, my other research groups work involves restrospective data collection in the field of clinical toxicology and optimising the management and prevention of poisoning and toxicity.

Education/Academic qualification

1 Feb 201415 Mar 2017

Award Date: 15 Mar 2017

PhD, University of Hertfordshire

Award Date: 15 Sep 2016

Master, University of Hertfordshire

Award Date: 1 Jun 2012

Bachelor, Ajman University

Award Date: 2 Aug 2010

College of Technological Studies Kuwait

Award Date: 12 Jan 2006

External positions

Postdoctoral research assistant, St. George's University of London

1 Apr 202130 Sep 2022

Interim hospital pharmacist, Al-Adan Hospital

31 May 202028 Feb 2021

Hospital pharmacist

15 Mar 20201 Apr 2021

Senior postdoctoral research associate, University of Bristol

13 Jun 201715 Sep 2018

Postdoctoral research associate, University of Bath

1 Dec 201631 May 2017

Visiting lecturer

15 Sep 20138 Jan 2017

QAQC analyst

1 Jul 201228 Feb 2013

Keywords

  • RM Therapeutics. Pharmacology
  • Pharmacy
  • Toxicology
  • Research Methods
  • Statistics
  • Healthcare

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