Personal profile

Research interests

My research as an in vitro pharmacologist has been to work on numerous projects involved with molecular mechanisms that underpin numerous disease states, such as nuclear receptors involved in inflammation and the use and side effects of NSAIDs. My background has been to study vasoactive compounds that control vascular function, and over the past couple of years I have worked in multi-disciplinary groups to screen for drugs that control pancreatic diseases, both diabetes and cancer. My expertise has taken me a number of interesting routes, and in collaboration with several others from Glasgow University, Lincoln University and Oxford University, we  developed a new statistical method using artificial intelligence to predict who has the virus SARS CoV2 at a very early stage of infection using only simple blood tests, and then applied these techniques to develop new prediction models for diseases. 

I am focused on improving the educational path for all students so that they may gain the career path most suited to their interests and talents. In my role of Learning and Teaching Lead for the School of Applied Sciences, I find ways to ensure there is a consistent approach taken to all aspects of assessments, ensuring transparency and parity for all. Some of my more recent research has been on how students study and engage with the large amount of content, with the aim of developing a streamlined approach to aid students.

In my teaching you will find me talking with passion about pharmacology and biochemistry, especially in Biomedical Science. I teach using primary sources of data and case studies, and make sure that students have the background knowledge so they can apply this to real world problems to solve.

Supervisory Interests

A large proportion of my previous research has focused on how nuclear receptors control transcription and thus control how cells respond on the long term to pathogens and chronic disease states.
Projects on offer involve:
1. Understanding how nuclear receptors may be manipulated to ensure a rapid response to new pathogens without harming the patient
2. Changing cell function using nuclear receptor agonists to manipulate human blood derived progenitor cells to create new organs such as lung and deepening our understanding of how PPARβδ receptors control inflammation and disease. 
Two other in vitro projects in collaboration with other universities; to isolate or identify hit compounds to control diabetes and pancreatic cancer. One set of compounds have been isolated form natural plant products from Gabon (the extract is already in use to control diabetes in humans), while the other screening cascade involves compounds have been designed via computational chemistry Collaborators: Hertfordshire University and IPHAMETRA institute, Gabon.

Education/Academic qualification

Senior Fellow HEA, The Higher Education Academy (HEA)

Award Date: 17 Jun 2024

Fellow of the IBMS, Institute of Biomedical Science

Award Date: 1 Jan 2023

Fellow of the HEA, The Higher Education Academy (HEA)

Award Date: 6 Oct 2014

Postgraduate Certificate Learning and Teaching in Higher Education, University of Hertfordshire

Award Date: 19 Sept 2014

PhD, The Role of PLC isoforms in the Regulating Differentiated function in Vascular Smooth Muscle, Imperial College London

1 Oct 20001 Oct 2003

Award Date: 30 Nov 2003

Bachelor, Biological Sciences with Microbiology, University of Warwick

Award Date: 11 Jul 1996

External positions

External Examiner

10 Oct 20249 Oct 2028

Deputy Chair Special Advisory Group (Academic), Institute of Biomedical Science

5 Jun 2024 → …

Non-Accredited Degree Assessor , Institute of Biomedical Science

21 Jul 2023 → …

Co-Chair of the Effective Feedback and Assessments Community Group

22 Jun 2022 → …

Senior Lecturer Pharmacology, University of Hertfordshire

20132018

Senior Post Doctoral Research Fellow, NHLI

20072013

Post-Doctoral Research Associate, The William Harvey Research Institute

20042007

Post-Doctoral Research Assistant, NHLI

20022004

Research Assistant, Hatter Institute

19982000

Research Assistant, Wellcome Trust for Human Genetics, University of Oxford

19971998

Fingerprint

Dive into the research topics where Louise MacKenzie is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
  • 4 Similar Profiles

Collaborations and top research areas from the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or