Projects per year
Personal profile
Research interests
My research as an in vitro pharmacologist has been to work on numerous projects involved with molecular mechanisms that underpin numerous disease states, such as nuclear receptors involved in inflammation and the use and side effects of NSAIDs. My background has been to study vasoactive compounds that control vascular function, and over the past couple of years I have worked in multi-disciplinary groups to screen for drugs that control pancreatic diseases, both diabetes and cancer. My expertise has taken me a number of interesting routes, and in collaboration with several others from Glasgow University, Lincoln University and Oxford University, we developed a new statistical method using artificial intelligence to predict who has the virus SARS CoV2 at a very early stage of infection using only simple blood tests, and then applied these techniques to develop new prediction models for diseases.
I am focused on improving the educational path for all students so that they may gain the career path most suited to their interests and talents. In my role of Learning and Teaching Lead for the School of Applied Sciences, I find ways to ensure there is a consistent approach taken to all aspects of assessments, ensuring transparency and parity for all. Some of my more recent research has been on how students study and engage with the large amount of content, with the aim of developing a streamlined approach to aid students.
In my teaching you will find me talking with passion about pharmacology and biochemistry, especially in Biomedical Science. I teach using primary sources of data and case studies, and make sure that students have the background knowledge so they can apply this to real world problems to solve.
Supervisory Interests
A large proportion of my previous research has focused on how nuclear receptors control transcription and thus control how cells respond on the long term to pathogens and chronic disease states.
Projects on offer involve:
1. Understanding how nuclear receptors may be manipulated to ensure a rapid response to new pathogens without harming the patient
2. Changing cell function using nuclear receptor agonists to manipulate human blood derived progenitor cells to create new organs such as lung and deepening our understanding of how PPARβδ receptors control inflammation and disease.
Two other in vitro projects in collaboration with other universities; to isolate or identify hit compounds to control diabetes and pancreatic cancer. One set of compounds have been isolated form natural plant products from Gabon (the extract is already in use to control diabetes in humans), while the other screening cascade involves compounds have been designed via computational chemistry Collaborators: Hertfordshire University and IPHAMETRA institute, Gabon.
Education/Academic qualification
Senior Fellow HEA, The Higher Education Academy (HEA)
Award Date: 17 Jun 2024
Fellow of the IBMS, Institute of Biomedical Science
Award Date: 1 Jan 2023
Fellow of the HEA, The Higher Education Academy (HEA)
Award Date: 6 Oct 2014
Postgraduate Certificate Learning and Teaching in Higher Education, University of Hertfordshire
Award Date: 19 Sept 2014
PhD, The Role of PLC isoforms in the Regulating Differentiated function in Vascular Smooth Muscle, Imperial College London
1 Oct 2000 → 1 Oct 2003
Award Date: 30 Nov 2003
Bachelor, Biological Sciences with Microbiology, University of Warwick
Award Date: 11 Jul 1996
External positions
External Examiner
10 Oct 2024 → 9 Oct 2028
Deputy Chair Special Advisory Group (Academic), Institute of Biomedical Science
5 Jun 2024 → …
Non-Accredited Degree Assessor , Institute of Biomedical Science
21 Jul 2023 → …
Co-Chair of the Effective Feedback and Assessments Community Group
22 Jun 2022 → …
Senior Lecturer Pharmacology, University of Hertfordshire
2013 → 2018
Senior Post Doctoral Research Fellow, NHLI
2007 → 2013
Post-Doctoral Research Associate, The William Harvey Research Institute
2004 → 2007
Post-Doctoral Research Assistant, NHLI
2002 → 2004
Research Assistant, Hatter Institute
1998 → 2000
Research Assistant, Wellcome Trust for Human Genetics, University of Oxford
1997 → 1998
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- 4 Similar Profiles
Collaborations and top research areas from the last five years
Projects
- 1 Finished
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Tabernanthe iboga (TiAE) in isolated pancreatic islets of Langerhan
MacKenzie, L. (PI), Macfarlane, W. (CoI), Lione, L. (CoI), BADING-TAIKA, B. (PI), Zloh, M. (CoI) & Souza, A. (PI)
1/01/14 → 31/12/18
Project: Research
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A robust COVID‑19 mortality prediction calculator based on Lymphocyte count, Urea, C‑Reactive Protein, Age and Sex (LUCAS) with chest X‑rays
Ray, S., Banerjee, A., Swift, A. J., Fanstone, J., Mamalakis, M., Vorselaars, B., Wilkie, C., Cole, J., Mackenzie, L. S. & Weeks, S., 29 Oct 2022, In: Scientific Reports. 12, 1, 14 p., 18220.Research output: Contribution to journal › Article › peer-review
Open Access -
Development of a Mortality Prediction Model in Hospitalised SARS-CoV-2 Positive Patients Based on Routine Kidney Biomarkers
Boss, A., Banerjee, A., Mamalakis, M., Ray, S., Swift, A. J., Wilkie, C., Fanstone, J., Vorselaars, B., Cole, J., Weeks, S. & Mackenzie, L. S., 30 Jun 2022, In: International Journal of Molecular Sciences. 23, 13, 13 p., 7260.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
A simplified risk tool, LUCAS, which predicts the outcome for patients with SARS-CoV-2 also predicts survival from Influenza A and Influenza B infections.
Wilkie, C., Ray, S., Banerjee, A., Mamalakis, M., Swift, A. J., Vorselaars, B., Fanstone, J., Weeks, S. & Mackenzie, L. S., 7 Sept 2021.Research output: Contribution to conference › Abstract › peer-review
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Can kidney function be used to predict survival of COVID-19 in hospitals? Predictive modelling in a retrospective cohort study.
Mackenzie, L. S., Wilkie, C., Ray, S., Banerjee, A., Mamalakis, M., Swift, A. J., Vorselaars, B., Fanstone, J. & Weeks, S., 7 Sept 2021.Research output: Contribution to conference › Abstract › peer-review
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Co-Incubation with PPARβ/δ Agonists and Antagonists Modeled Using Computational Chemistry: Effect on LPS Induced Inflammatory Markers in Pulmonary Artery
Perez Diaz, N., Lione, L., Hutter, V. & Mackenzie, L. S., 19 Mar 2021, In: International Journal of Molecular Sciences. 22, 6, p. 1-19 19 p., 3158.Research output: Contribution to journal › Article › peer-review
Open AccessFile