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Personal profile

Research interests

Dr Louise Mackenzie is an in vitro pharmacologist who works on numerous projects involved with molecular mechanisms that underpin numerous disease states, such as nuclear receptors involved in inflammation.

Her background has been to study vasoactive compounds that control vascular function, but more recently she has worked in multi-disciplinary groups to screen for drugs that control pancreatic diseases, both diabetes and cancer.

Supervisory Interests

Manipulating human blood derived progenitor cells to create different cell types using nuclear receptor agonists.

Deepening our understanding of how PPARβδ receptors control inflammation and disease

Defining the off-target effects of non-steroidal anti-inflammatory drugs

In vitro assay design: anti-diabetic actions of natural plant products (in collaboration with Hertfordshire University and Gabon University)

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Celecoxib Medicine & Life Sciences
Blood Vessels Medicine & Life Sciences
Cyclooxygenase 2 Medicine & Life Sciences
Peroxisome Proliferator-Activated Receptors Medicine & Life Sciences
Epoprostenol Medicine & Life Sciences
Endothelium Medicine & Life Sciences
Cyclooxygenase 1 Medicine & Life Sciences
Vasodilation Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1998 2019

Off-target interactions as novel explantion of NSAID CV risk

Dolan, G., MacKenzie, L., Zloh, M. & Lione, L., Apr 2019.

Research output: Contribution to conferenceAbstractResearch

Open Access
File
Cardiovascular Agents
Anti-Inflammatory Agents
Diclofenac
Naproxen
Cytoplasmic and Nuclear Receptors

Regulation of pulmonary artery inflamation by PPARβ/δ

Perez Diaz, N., Lione, L., MacKenzie, L. & Hutter, V., Apr 2019.

Research output: Contribution to conferenceAbstractResearch

Open Access
File
PPAR delta
Pulmonary Artery
Inflammation
Transcription Factors
Anti-Inflammatory Agents

An overview of anti-diabetic plants used in Gabon: Pharmacology and toxicology

Bading Taika, B., Bouckandou, M., Souza, A., Bourobou Bourobou, H. P., Mackenzie, L. & Lione, L. A., 2 Jan 2018, In : Journal of Ethnopharmacology. 216, p. 203-228 26 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Gabon
Toxicology
Pharmacology
Hyperglycemia
Tabernaemontana

Predicted interactions of selected NSAIDS with hERG potassium channel using Virtual Toxlab

Dolan, G., MacKenzie, L., Zloh, M. & Lione, L., Mar 2018.

Research output: Contribution to conferenceAbstractResearch

Open Access
File
Celecoxib
Potassium Channels
Anti-Inflammatory Agents
Cardiac Arrhythmias
etoricoxib

The non-genomic effects of the PPARβ/δ agonist GW0742 on STZ treated rat aorta

Perez-Diaz, N., Pushkarsky, I., Oweis, N., Lione, L. A. & Mackenzie, L., 2018, In : Current Molecular Pharmacology. 11, 2, p. 149-154 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Peroxisome Proliferator-Activated Receptors
Aorta
Dilatation
GW0742
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid