Architectures and Mechanical Properties of Drugs and Complexes of Surface-Active Compounds at Air-Water and Oil-Water Interfaces

Research output: Contribution to journalArticle

Abstract

Abstract: Background: Drugs can represent a multitude of compounds from proteins and peptides, such as growth hormones and insulin and on to simple organic molecules such as flurbiprofen, ibuprofen and lidocaine. Given the chemical nature of these compounds two features are always present. A portion or portions of the molecule that has little affinity for apolar surfaces and media and on the contrary a series of part or one large part that has considerable affinity for hydrophilic, polar or charged media and surfaces. A series of techniques are routinely used to probe the molecular interactions that can arise between components, such as the drug, a range of surface-active excipients and flavor compounds, for example terpenoids and the solvent or dispersion medium. Results: Fifty-eight papers were included in the review, a large number (16) being of theoretical nature and an equally large number (14) directly pertaining to medicine and pharmacy; alongside experimental data and phenomenological modelling. The review therefore simultaneously represents an amalgam of review article and research paper with routinely used or established (10) and wellreported methodologies (also included in the citations within the review). Experimental data included from various sources as diverse as foam microconductivity, interferometric measurements of surface adsorbates and laser fluorescence spectroscopy (FRAP) are used to indicate the complexity and utility of foams and surface soft matter structures for a range of purposes but specifically, here for encapsulation and incorporation of therapeutics actives (pharmaceutical molecules, vaccines and excipients used in medicaments). Techniques such as interfacial tensiometry, interfacial rheology (viscosity, elasticity and viscoelasticity) and nanoparticle particle size (hydrodynamic diameter) and charge measurements (zeta potential), in addition to atomic force and scanning electron microscopy have proven to be very useful in understanding how such elemental components combine, link or replace one another (competitive displacement). They have also proven to be both beneficial and worthwhile in the sense of quantifying the unseen actions and interplay of adsorbed molecules and the macroscopic effects, such as froth formation, creaming or sedimentation that can occur as a result of these interactions.
Original languageEnglish
JournalCurrent Drug Discovery Technologies
Volume14
DOIs
Publication statusPublished - 1 Jan 2018

Bibliographical note

The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/openurl/content.php?genre=article&doi=10.2174/1570163814666171117132202

Keywords

  • adsorbed layer
  • crosslinking
  • surfactant
  • polymer
  • drug

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  • Activities

    • 1 Research degree
    • 1 Invited talk
    • 1 Oral presentation

    Masters Degree by Research (France) - Mr Victor Jasny (University of Tours at Blois)

    Dipak Sarker (Supervisor)

    1 Mar 20201 Aug 2020

    Activity: External examination and supervisionResearch degree

    Functional Foods and Food Functionalisation.

    Dipak Sarker (Presenter)

    4 Feb 2015

    Activity: External talk or presentationInvited talk

    Interfacial rheological properties of Tween20: β-lactoglobulin mixed systems as affected by phenolic antioxidant compounds.

    Dipak Sarker (Presenter)

    21 Mar 201024 Mar 2010

    Activity: External talk or presentationOral presentation

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