Rapid Adsorption of Proinflammatory Cytokines by Graphene Nanoplatelets and Their Composites for Extracorporeal Detoxification

Yishan Zheng, Nicholas Pescatore, Yury Gogotsi, Boris Dyatkin, Ganesh Ingavle, Vadym Mochalin, Tochukwu Ozulumba, Sergey Mikhalovsky, Susan Sandeman

Research output: Contribution to journalArticleResearch

Abstract

Sepsis is a complex clinical syndrome that features excessive release of cytokines and other inflammatory mediators that could lead to organ dysfunction. Despite different treatment and management options, sepsis associated high morbidity and mortality rates remain. This has prompted intensive research into alternative therapeutic approaches such as targeted removal of sepsis related molecules using extracorporeal hemoperfusion. In this study, we explore the use of graphene nanoplatelets (GNP) as low- cost alternative hemosorbents for rapid removal of a broad spectrum of proinflammatory cytokine markers. Firstly, the physical characteristics, cytotoxicity, and cytokine marker adsorption profile of GNP were assessed. The results not only confirmed the surface characteristics of GNP and their ability to rapidly remove cytokine markers, but also indicated a low cytotoxicity towards the hepatic cell line HepG2. GNP were then incorporated into a freestanding flexible GNP-poly(tetrafluoroethy lm with preserved surface characteristics and cytokine adsorption profile for potential use in hemoperfusion applications.
Original languageEnglish
JournalJournal of Nanomaterials
Volume2018
DOIs
Publication statusPublished - 21 Feb 2018

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Adsorption
Cytokines
Hemoperfusion
Sepsis
Hepatocytes
Morbidity
Costs and Cost Analysis
Cell Line
Mortality
Therapeutics
Research

Bibliographical note

Copyright © 2018 Yishan Zheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Cite this

Zheng, Yishan ; Pescatore, Nicholas ; Gogotsi, Yury ; Dyatkin, Boris ; Ingavle, Ganesh ; Mochalin, Vadym ; Ozulumba, Tochukwu ; Mikhalovsky, Sergey ; Sandeman, Susan. / Rapid Adsorption of Proinflammatory Cytokines by Graphene Nanoplatelets and Their Composites for Extracorporeal Detoxification. In: Journal of Nanomaterials. 2018 ; Vol. 2018.
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abstract = "Sepsis is a complex clinical syndrome that features excessive release of cytokines and other inflammatory mediators that could lead to organ dysfunction. Despite different treatment and management options, sepsis associated high morbidity and mortality rates remain. This has prompted intensive research into alternative therapeutic approaches such as targeted removal of sepsis related molecules using extracorporeal hemoperfusion. In this study, we explore the use of graphene nanoplatelets (GNP) as low- cost alternative hemosorbents for rapid removal of a broad spectrum of proinflammatory cytokine markers. Firstly, the physical characteristics, cytotoxicity, and cytokine marker adsorption profile of GNP were assessed. The results not only confirmed the surface characteristics of GNP and their ability to rapidly remove cytokine markers, but also indicated a low cytotoxicity towards the hepatic cell line HepG2. GNP were then incorporated into a freestanding flexible GNP-poly(tetrafluoroethy lm with preserved surface characteristics and cytokine adsorption profile for potential use in hemoperfusion applications.",
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Rapid Adsorption of Proinflammatory Cytokines by Graphene Nanoplatelets and Their Composites for Extracorporeal Detoxification. / Zheng, Yishan; Pescatore, Nicholas; Gogotsi, Yury; Dyatkin, Boris; Ingavle, Ganesh; Mochalin, Vadym; Ozulumba, Tochukwu; Mikhalovsky, Sergey; Sandeman, Susan.

In: Journal of Nanomaterials, Vol. 2018, 21.02.2018.

Research output: Contribution to journalArticleResearch

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AU - Ingavle, Ganesh

AU - Mochalin, Vadym

AU - Ozulumba, Tochukwu

AU - Mikhalovsky, Sergey

AU - Sandeman, Susan

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