TY - JOUR
T1 - Nanoporous activated carbon beads and monolithic columns as effective hemoadsorbents for inflammatory cytokines
AU - Howell, Carol
AU - Sandeman, Susan
AU - Phillips, Gary
AU - Mikhalovsky, Sergey
AU - Tennison, S.R.
AU - Rawlinson, A.P.
AU - Kozynchenko, O.P.
PY - 2013/10/3
Y1 - 2013/10/3
N2 - The aim of the present study was to develop and investigate nanoporous activated carbon materials for their ability to adsorb inflammatory cytokines directly from blood, for a range of therapeutic applications, including: systemic inflammatory response syndrome (SIRS) related to sepsis, cardio-pulmonary by-pass surgery, or ischemic reperfusion injury. Building on the previously established relationship between the porous structure of beaded polymer-derived activated carbon and its capacity to adsorb inflammatory molecules, we have developed and characterized monolithic porous carbon columns produced from the same polymer precursor matrix as carbon microbeads. The monolithic columns developed were assessed for their ability to adsorb inflammatory molecules from blood in a circulating system. Preliminary findings demonstrated good removal of the inflammatory cytokines IL-8 (100% removal), IL-6 (80% removal), and TNF (51% removal) from blood. The efficiency of cleansing is dependent on the size of the adsorbed molecule and the porous structure of the monolith, highlighting their potential for use as a hemoadsorption device.
AB - The aim of the present study was to develop and investigate nanoporous activated carbon materials for their ability to adsorb inflammatory cytokines directly from blood, for a range of therapeutic applications, including: systemic inflammatory response syndrome (SIRS) related to sepsis, cardio-pulmonary by-pass surgery, or ischemic reperfusion injury. Building on the previously established relationship between the porous structure of beaded polymer-derived activated carbon and its capacity to adsorb inflammatory molecules, we have developed and characterized monolithic porous carbon columns produced from the same polymer precursor matrix as carbon microbeads. The monolithic columns developed were assessed for their ability to adsorb inflammatory molecules from blood in a circulating system. Preliminary findings demonstrated good removal of the inflammatory cytokines IL-8 (100% removal), IL-6 (80% removal), and TNF (51% removal) from blood. The efficiency of cleansing is dependent on the size of the adsorbed molecule and the porous structure of the monolith, highlighting their potential for use as a hemoadsorption device.
KW - Activated charcoal
KW - Cytokines
KW - Extracorporeal circulation
KW - Porosity
U2 - 10.5301/ijao.5000231
DO - 10.5301/ijao.5000231
M3 - Article
SN - 0391-3988
VL - 36
SP - 624
EP - 632
JO - International Journal of Artificial Organs
JF - International Journal of Artificial Organs
IS - 9
ER -