Determining the identity of the cochlear amplifier: Electrical stimulation of the tecta mouse cochlea

Marcia M. Mellado Lagarde, Markus Drexl, Victoria A. Lukashkina, Andrei N. Lukashkin, Ian J. Russell

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNConference contribution with ISSN or ISBN

Abstract

The sensitivity, large dynamic range and narrow frequency tuning of the mammalian cochlea is determined by the passive mechanical properties of the basilar membrane (BM) and active feedback from the outer hair cells (OHCs). Two mechanisms have been proposed to provide amplification: Hair bundle motility, and OHC somatic-motility. Acoustically- and electrically-elicited mechanical responses were measured from the BMs of the cochleae of wild type and genetically modified mice where the hair bundles are freestanding and cannot react against the tectorial membrane (TM) to contribute to amplification. We found the electrically elicited responses in mutant mice, where only somatic motility can provide amplification, to be remarkably similar to acoustical and electrical responses in the wild type animals. We, therefore, conclude that somatic, not stereocilia motility is the basis of the cochlear amplifier.

Original languageEnglish
Title of host publicationConcepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008
EditorsDavid T. Kemp, Nigel P. Cooper
PublisherWorld Scientific Publishing Co. Pte Ltd
Pages106-112
Number of pages7
ISBN (Electronic)9789812833778
Publication statusPublished - 1 Jan 2008
Event10th International Workshop on the Mechanics of Hearing - Concepts and Challenges in the Biophysics of Hearing, MoH 2008 - Newcastle, United Kingdom
Duration: 27 Jul 200831 Jul 2008

Publication series

NameConcepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008

Conference

Conference10th International Workshop on the Mechanics of Hearing - Concepts and Challenges in the Biophysics of Hearing, MoH 2008
CountryUnited Kingdom
CityNewcastle
Period27/07/0831/07/08

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    Mellado Lagarde, M. M., Drexl, M., Lukashkina, V. A., Lukashkin, A. N., & Russell, I. J. (2008). Determining the identity of the cochlear amplifier: Electrical stimulation of the tecta mouse cochlea. In D. T. Kemp, & N. P. Cooper (Eds.), Concepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008 (pp. 106-112). (Concepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008). World Scientific Publishing Co. Pte Ltd.