TY - GEN
T1 - Determining the identity of the cochlear amplifier
T2 - 10th International Workshop on the Mechanics of Hearing - Concepts and Challenges in the Biophysics of Hearing, MoH 2008
AU - Mellado Lagarde, Marcia M.
AU - Drexl, Markus
AU - Lukashkina, Victoria A.
AU - Lukashkin, Andrei N.
AU - Russell, Ian J.
PY - 2008/1/1
Y1 - 2008/1/1
N2 - The sensitivity, large dynamic range and narrow frequency tuning of the mammalian cochlea is determined by the passive mechanical properties of the basilar membrane (BM) and active feedback from the outer hair cells (OHCs). Two mechanisms have been proposed to provide amplification: Hair bundle motility, and OHC somatic-motility. Acoustically- and electrically-elicited mechanical responses were measured from the BMs of the cochleae of wild type and genetically modified mice where the hair bundles are freestanding and cannot react against the tectorial membrane (TM) to contribute to amplification. We found the electrically elicited responses in mutant mice, where only somatic motility can provide amplification, to be remarkably similar to acoustical and electrical responses in the wild type animals. We, therefore, conclude that somatic, not stereocilia motility is the basis of the cochlear amplifier.
AB - The sensitivity, large dynamic range and narrow frequency tuning of the mammalian cochlea is determined by the passive mechanical properties of the basilar membrane (BM) and active feedback from the outer hair cells (OHCs). Two mechanisms have been proposed to provide amplification: Hair bundle motility, and OHC somatic-motility. Acoustically- and electrically-elicited mechanical responses were measured from the BMs of the cochleae of wild type and genetically modified mice where the hair bundles are freestanding and cannot react against the tectorial membrane (TM) to contribute to amplification. We found the electrically elicited responses in mutant mice, where only somatic motility can provide amplification, to be remarkably similar to acoustical and electrical responses in the wild type animals. We, therefore, conclude that somatic, not stereocilia motility is the basis of the cochlear amplifier.
UR - http://www.scopus.com/inward/record.url?scp=82955251582&partnerID=8YFLogxK
M3 - Conference contribution with ISSN or ISBN
AN - SCOPUS:82955251582
T3 - Concepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008
SP - 106
EP - 112
BT - Concepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008
A2 - Kemp, David T.
A2 - Cooper, Nigel P.
PB - World Scientific Publishing Co. Pte Ltd
Y2 - 27 July 2008 through 31 July 2008
ER -