Cryogels: morphological, structural and adsorption characterisation

V.M. Gun'ko; Irina Savina; Sergey Mikhalovsky

doi:10.1016/j.cis.2012.11.001

Cryogels: morphological, structural and adsorption characterisation

V.M. Gun'ko, Irina Savina, Sergey Mikhalovsky

Research output: Contribution to journal › Article › peer-review

Abstract

Experimental results on polymer, protein, and composite cryogels and data treatment methods used for morphological, textural, structural, adsorption and diffusion characterisation of the materials are analysed and compared. Treatment of microscopic images with specific software gives quantitative structural information on both native cryogels and freeze-dried materials that is useful to analyse the drying effects on their structure. A combination of cryoporometry, relaxometry, thermoporometry, small angle X-ray scattering (SAXS), equilibrium and kinetic adsorption of low and high-molecular weight compounds, diffusion breakthrough of macromolecules within macroporous cryogel membranes, studying interactions of cells with cryogels provides a consistent and comprehensive picture of textural, structural and adsorption properties of a variety of cryogels. This analysis allows us to establish certain regularities in the cryogel properties related to narrow (diameter 0.4100 μm) with boundary sizes within modified life science pore classification. Particular attention is paid to water bound in cryogels in native superhydrated or freeze-dried states. At least, five states of water - free unbound, weakly bound (changes in the Gibbs free energy-ΔG<0.5-0.8 kJ/mol) and strongly bound (-ΔG>0.8 kJ/mol), and weakly associated (chemical shift of the proton resonance δ(H)=1-2 ppm) and strongly associated (δ(H)=3-6 ppm) waters can be distinguished in hydrated cryogels using (1)H NMR, DSC, TSDC, TG and other methods. Different software for image treatment or developed to analyse the data obtained with the adsorption, diffusion, SAXS, cryoporometry and thermoporometry methods and based on regularisation algorithms is analysed and used for the quantitative morphological, structural and adsorption characterisation of individual and composite cryogels, including polymers filled with solid nano- or microparticles.

Original language	English
Pages (from-to)	1-46
Number of pages	46
Journal	Advances in Colloid and Interface Science
Volume	187-18
DOIs	https://doi.org/10.1016/j.cis.2012.11.001
Publication status	Published - 31 Jan 2013

Bibliographical note

Journal Article, Research Support, Non-U.S. Gov't, Review. This is the author’s version of a work that was accepted for publication in Advances in Colloid and Interface Science. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Advances in Colloid and Interface Science, 187-188, (2013) DOI 10.1016/j.cis.2012.11.001

Keywords

Cryogel
Structural characteristics
Microscopic image treatment
Cryoporometry
Thermoporometry
Adsorption
Diffusion
Interfacial phenomena

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title = "Cryogels: morphological, structural and adsorption characterisation",

abstract = "Experimental results on polymer, protein, and composite cryogels and data treatment methods used for morphological, textural, structural, adsorption and diffusion characterisation of the materials are analysed and compared. Treatment of microscopic images with specific software gives quantitative structural information on both native cryogels and freeze-dried materials that is useful to analyse the drying effects on their structure. A combination of cryoporometry, relaxometry, thermoporometry, small angle X-ray scattering (SAXS), equilibrium and kinetic adsorption of low and high-molecular weight compounds, diffusion breakthrough of macromolecules within macroporous cryogel membranes, studying interactions of cells with cryogels provides a consistent and comprehensive picture of textural, structural and adsorption properties of a variety of cryogels. This analysis allows us to establish certain regularities in the cryogel properties related to narrow (diameter 0.4100 μm) with boundary sizes within modified life science pore classification. Particular attention is paid to water bound in cryogels in native superhydrated or freeze-dried states. At least, five states of water - free unbound, weakly bound (changes in the Gibbs free energy-ΔG<0.5-0.8 kJ/mol) and strongly bound (-ΔG>0.8 kJ/mol), and weakly associated (chemical shift of the proton resonance δ(H)=1-2 ppm) and strongly associated (δ(H)=3-6 ppm) waters can be distinguished in hydrated cryogels using (1)H NMR, DSC, TSDC, TG and other methods. Different software for image treatment or developed to analyse the data obtained with the adsorption, diffusion, SAXS, cryoporometry and thermoporometry methods and based on regularisation algorithms is analysed and used for the quantitative morphological, structural and adsorption characterisation of individual and composite cryogels, including polymers filled with solid nano- or microparticles.",

keywords = "Cryogel, Structural characteristics, Microscopic image treatment, Cryoporometry, Thermoporometry, Adsorption, Diffusion, Interfacial phenomena",

author = "V.M. Gun'ko and Irina Savina and Sergey Mikhalovsky",

note = "Journal Article, Research Support, Non-U.S. Gov't, Review. This is the author{\textquoteright}s version of a work that was accepted for publication in Advances in Colloid and Interface Science. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Advances in Colloid and Interface Science, 187-188, (2013) DOI 10.1016/j.cis.2012.11.001",

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doi = "10.1016/j.cis.2012.11.001",

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AU - Gun'ko, V.M.

AU - Savina, Irina

AU - Mikhalovsky, Sergey

N1 - Journal Article, Research Support, Non-U.S. Gov't, Review. This is the author’s version of a work that was accepted for publication in Advances in Colloid and Interface Science. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Advances in Colloid and Interface Science, 187-188, (2013) DOI 10.1016/j.cis.2012.11.001

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AB - Experimental results on polymer, protein, and composite cryogels and data treatment methods used for morphological, textural, structural, adsorption and diffusion characterisation of the materials are analysed and compared. Treatment of microscopic images with specific software gives quantitative structural information on both native cryogels and freeze-dried materials that is useful to analyse the drying effects on their structure. A combination of cryoporometry, relaxometry, thermoporometry, small angle X-ray scattering (SAXS), equilibrium and kinetic adsorption of low and high-molecular weight compounds, diffusion breakthrough of macromolecules within macroporous cryogel membranes, studying interactions of cells with cryogels provides a consistent and comprehensive picture of textural, structural and adsorption properties of a variety of cryogels. This analysis allows us to establish certain regularities in the cryogel properties related to narrow (diameter 0.4100 μm) with boundary sizes within modified life science pore classification. Particular attention is paid to water bound in cryogels in native superhydrated or freeze-dried states. At least, five states of water - free unbound, weakly bound (changes in the Gibbs free energy-ΔG<0.5-0.8 kJ/mol) and strongly bound (-ΔG>0.8 kJ/mol), and weakly associated (chemical shift of the proton resonance δ(H)=1-2 ppm) and strongly associated (δ(H)=3-6 ppm) waters can be distinguished in hydrated cryogels using (1)H NMR, DSC, TSDC, TG and other methods. Different software for image treatment or developed to analyse the data obtained with the adsorption, diffusion, SAXS, cryoporometry and thermoporometry methods and based on regularisation algorithms is analysed and used for the quantitative morphological, structural and adsorption characterisation of individual and composite cryogels, including polymers filled with solid nano- or microparticles.

KW - Cryogel

KW - Structural characteristics

KW - Microscopic image treatment

KW - Cryoporometry

KW - Thermoporometry

KW - Adsorption

KW - Diffusion

KW - Interfacial phenomena

U2 - 10.1016/j.cis.2012.11.001

DO - 10.1016/j.cis.2012.11.001

M3 - Article

SN - 0001-8686

VL - 187-18

SP - 1

EP - 46

JO - Advances in Colloid and Interface Science

JF - Advances in Colloid and Interface Science

ER -

Cryogels: morphological, structural and adsorption characterisation

Abstract

Bibliographical note

Keywords

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