Malodorous chronic wounds are associated with significant patient morbidity and can be responsible for patient social isolation and depression. A new material with favourable physical properties for easy application to difficult-to-dress bodily surfaces was tested for its ability to reduce the human detection of malodorous 2-aminoacetophenone, the dominant odour associated with chronic ulcers infected with Pseudomonas aeruginosa. The material consisted of activated carbon (AC) particles held within a plasticised agarose (PA) film. This material, PA-AC, was relatively thin and could be folded and cut to shape without appreciable loss of the AC particulates. In a study using human volunteers, the intensity of 2-AAP odour was (strongly) significantly lower for the PA-AC material when compared with controls. Additionally, mechanical studies indicated that the presence of AC did not alter the maximum load, extension at maximum load, or percentage elongation of the PA films, with no statistically significant difference between PA-AC and PA. Supplementation of the agarose films (with or without AC) with carboxymethylcellulose (CMC) enabled fluid handling to be increased by 176% and 163%, respectively. PA-AC, PA and PA-AC-CMC, PA-CMC allowed water vapour transmission at a rate previously reported to promote wound healing, while preventing tissue maceration caused by excessive sweat retention. A range of agarose films with variable odour and fluid handling properties are envisaged for further development towards wound management applications.
|Number of pages||10|
|Journal||Journal of Materials Science|
|Publication status||Published - 26 Aug 2022|
Bibliographical noteFunding Information:
The mechanical and fluid handling tests were performed by BG Healthcare (CH1 1SL, UK), using samples made and supplied by the University of Brighton.
This work has received funding from the Interreg 2 Seas programme 2014-2020 co-funded by the European Regional Development Fund under subsidy contract number DERMA 2SO1-02.
© 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.