The preservation of nasal preparations

Alison Lansley; Claire Marriott

doi:10.1016/0265-3036(88)90071-1

The preservation of nasal preparations

Alison Lansley, Claire Marriott

University of Brighton

Research output: Contribution to journal › Article › peer-review

Abstract

The intranasal route of administration provides an effective and convenient means of delivering a number of compounds to the systemic circulation when the more usual oral or parenteral routes are inappropriate. The preservation of multi-dose nasal drops and sprays is essential. However, preservatives should not impair any of the normal functions of the nasal cavity, such as mucociliary clearance, since patients with compromised clearance can suffer extensively from respiratory tract infections. This paper reviews the results of a number of investigations into the effects of a range of commonly used preservatives on the mucociliary clearance apparatus.

Original language	English
Pages (from-to)	7-15
Number of pages	9
Journal	International Biodeterioration
Volume	24
Issue number	1
DOIs	https://doi.org/10.1016/0265-3036(88)90071-1
Publication status	Published - 31 Dec 1988

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title = "The preservation of nasal preparations",

abstract = "The intranasal route of administration provides an effective and convenient means of delivering a number of compounds to the systemic circulation when the more usual oral or parenteral routes are inappropriate. The preservation of multi-dose nasal drops and sprays is essential. However, preservatives should not impair any of the normal functions of the nasal cavity, such as mucociliary clearance, since patients with compromised clearance can suffer extensively from respiratory tract infections. This paper reviews the results of a number of investigations into the effects of a range of commonly used preservatives on the mucociliary clearance apparatus.",

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AB - The intranasal route of administration provides an effective and convenient means of delivering a number of compounds to the systemic circulation when the more usual oral or parenteral routes are inappropriate. The preservation of multi-dose nasal drops and sprays is essential. However, preservatives should not impair any of the normal functions of the nasal cavity, such as mucociliary clearance, since patients with compromised clearance can suffer extensively from respiratory tract infections. This paper reviews the results of a number of investigations into the effects of a range of commonly used preservatives on the mucociliary clearance apparatus.

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The preservation of nasal preparations

Abstract

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