The preservation of nasal preparations

Alison Lansley, Claire Marriott

Research output: Contribution to journalArticlepeer-review


The intranasal route of administration provides an effective and convenient means of delivering a number of compounds to the systemic circulation when the more usual oral or parenteral routes are inappropriate. The preservation of multi-dose nasal drops and sprays is essential. However, preservatives should not impair any of the normal functions of the nasal cavity, such as mucociliary clearance, since patients with compromised clearance can suffer extensively from respiratory tract infections. This paper reviews the results of a number of investigations into the effects of a range of commonly used preservatives on the mucociliary clearance apparatus.
Original languageEnglish
Pages (from-to)7-15
Number of pages9
JournalInternational Biodeterioration
Issue number1
Publication statusPublished - 31 Dec 1988


Dive into the research topics of 'The preservation of nasal preparations'. Together they form a unique fingerprint.

Cite this