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Personal profile

Scholarly biography

Dr Alison Lansley is a Principal Lecturer in Biopharmaceutics in the School of Pharmacy and Biomolecular Sciences at the University of Brighton. She graduated with a degree in Pharmacy and then studied the effect of preservatives on nasal mucociliary clearance for her PhD (both at the University of Brighton). After this, she went on to research ciliary activity and the role of calcium ions in intercellular communication at the University of California, Los Angeles.

Subsequently, Alison took up a postdoctoral and then lecturing position at King’s College London where she studied drug delivery to the airways. After a career break she was awarded a Daphne Jackson fellowship at the University of Sussex and from this she moved to her current position where her research interests include the effect of mucus on drug absorption in the respiratory tract and factors affecting mucociliary clearance, as well as optimising the treatment of asthma in children.

She teaches biopharmaceutics to undergraduate and postgraduate students and serves on the committee of the Inhalation Focus Group of the Academy of Pharmaceutical Sciences. She has supervised PhD students and postdoctoral researchers with funding from research councils, charities and industry and has published papers and book chapters on pulmonary and nasal drug delivery.

Approach to teaching

I teach on a wide variety of courses, both undergraduate and postgraduate, including the four-year pharmacy degree (MPharm). I specialise in biopharmaceutics and mainly teach about the factors affecting the bioavailability of drugs delivered by a number of different routes, considering the features of these routes as well as the physiocochemical properties of the drugs. I aim to engage the students by making my lectures interactive, with lots of questions and answers. I support this with Powerpoint slides and podcasts which student feedback indicates are particularly popular.

Research interests

I am interested in the delivery of drugs to the nose and lungs, particularly the use of in vivo-reflective in vitro cell culture models of the airway epithelium; the barrier to drug absorption. My interest in this area of pulmonary biopharmaceutics began in 1991; having worked on the Caco-2 cell culture model of the intestine I was interested in developing a similar model of the nose and/or lung. Most recently, our group has been studying the effect of mucus on airway drug absorption using two mucus-secreting cell lines (SPOC-1 and UNC-NT3) and the absorption of drugs from nanoparticles. In addition, I am interested in the role of mucociliary clearance on airway drug delivery, particularly the effect of formulation variables on this primary defence mechanism of the nose and lung. More recently I have also become interested in the bioavailability of inhaled drugs in children and adults and how this can be optimised.

Supervisory Interests

I am interested the in the absorption of drugs and particulates (including air pollution) in the airway and brain and their effect on permeability (cell junctions).  A particular interest is the role of mucus and mucociary clearance in drug/particulate delivery to the airway. I have supervised 11 successful PhD students and 5 postdoctoral scientists. Current projects available for supervision include: 

1. The delivery of drugs and particles to the nose and lungs, particularly the use of in vivo-reflective in vitro cell culture models of the airway epithelium and the role mucus and mucociliary clearance plays in drug and particulate delivery to the airways.

2. The bioavailability of inhaled drugs in children and adults and how this can be optimised in asthma and COPD.

3. Determining the impact of ultra-fine particulate air pollution (UFPs) on mucus secretion, ciliary activity and epithelial permeability in the young and ageing lung. Do UFPs accelerate lung ageing?

4. The mechanisms by which air pollution (ultrafine particles) crosses the blood brain barrier.


  • RS Pharmacy and materia medica
  • Nasal respiratory drug absorption epithelia

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Mucociliary Clearance Medicine & Life Sciences
Surface-Active Agents Chemical Compounds
Peptides Chemical Compounds
Oils Chemical Compounds
cefuroxime axetil Medicine & Life Sciences
Microemulsions Chemical Compounds
Respiratory System Medicine & Life Sciences
Monolayers Chemical Compounds

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Research Output 1988 2018

Nasal drug delivery

Lansley, A. & Martin, G., 1 Jan 2018, Aulton’s Pharmaceutics: The Design and Manufacture of Medicines (International edition). Aulton, M. & Taylor, K. (eds.). Edinburgh, p. 671-689 19 p.

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapterResearchpeer-review

Open Access
Pharmacy Students
Microbial Drug Resistance
Anti-Bacterial Agents
R Factors

How can we optimise inhaled beta2 agonist dose as 'reliever' medicine for wheezy pre-school children? Study protocol for a randomised controlled trial

Mukhopadhyay, S., Seddon, P., Earl, G., Wileman, E., Symes, L., Olden, C., Alberti, C., Bremner, S., Lansley, A., Palmer, C. N. A. & Beydon, N., 11 Nov 2016, In : Trials. 17

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Randomized Controlled Trials
Airway Resistance
Genetic Polymorphisms

Nasal drug delivery

Martin, G. & Lansley, A., 1 Jan 2013, Aulton’s Pharmaceutics: The Design and Manufacture of Medicines (International edition). Edinburgh, p. 657-674 18 p.

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapterResearch

Endothelin increases the ciliary beat frequency of ovine airway epithelium via its interaction with endothelin a receptors

Pawsey, J., Lansley, A. & Lethem, M., 1 Jun 2011, In : Pulmonary Pharmacology and Therapeutics. 24, 5, p. 602-609 8 p.

Research output: Contribution to journalArticleResearchpeer-review