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Personal profile

Scholarly biography

Dr Alison Lansley is a Principal Lecturer in Biopharmaceutics in the School of Pharmacy and Biomolecular Sciences at the University of Brighton. She graduated with a degree in Pharmacy and then studied the effect of preservatives on nasal mucociliary clearance for her PhD (both at the University of Brighton). After this, she went on to research ciliary activity and the role of calcium ions in intercellular communication at the University of California, Los Angeles.

Subsequently, Alison took up a postdoctoral and then lecturing position at King’s College London where she studied drug delivery to the airways. After a career break she was awarded a Daphne Jackson fellowship at the University of Sussex and from this she moved to her current position where her research interests include the effect of mucus on drug absorption in the respiratory tract and factors affecting mucociliary clearance, as well as optimising the treatment of asthma in children.

She teaches biopharmaceutics to undergraduate and postgraduate students and serves on the committee of the Inhalation Focus Group of the Academy of Pharmaceutical Sciences. She has supervised PhD students and postdoctoral researchers with funding from research councils, charities and industry and has published papers and book chapters on pulmonary and nasal drug delivery.

Approach to teaching

I teach on a wide variety of courses, both undergraduate and postgraduate, including the four-year pharmacy degree (MPharm). I specialise in biopharmaceutics and mainly teach about the factors affecting the bioavailability of drugs delivered by a number of different routes, considering the features of these routes as well as the physiocochemical properties of the drugs. I aim to engage the students by making my lectures interactive, with lots of questions and answers. I support this with Powerpoint slides and podcasts which student feedback indicates are particularly popular.

Research interests

I am interested in the delivery of drugs to the nose and lungs, particularly the use of in vivo-reflective in vitro cell culture models of the airway epithelium; the barrier to drug absorption. My interest in this area of pulmonary biopharmaceutics began in 1991; having worked on the Caco-2 cell culture model of the intestine I was interested in developing a similar model of the nose and/or lung. Most recently, our group has been studying the effect of mucus on airway drug absorption using two mucus-secreting cell lines (SPOC-1 and UNC-NT3) and the absorption of drugs from nanoparticles. In addition, I am interested in the role of mucociliary clearance on airway drug delivery, particularly the effect of formulation variables on this primary defence mechanism of the nose and lung. More recently I have also become interested in the bioavailability of inhaled drugs in children and adults and how this can be optimised.

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Mucociliary Clearance Medicine & Life Sciences
Surface-Active Agents Chemical Compounds
Oils Chemical Compounds
cefuroxime axetil Medicine & Life Sciences
Microemulsions Chemical Compounds
Respiratory System Medicine & Life Sciences
Peptides Chemical Compounds
Pharmaceutical Preparations Medicine & Life Sciences

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Research Output 1988 2017

Open Access
File
Pharmacy Students
Microbial Drug Resistance
Students
Anti-Bacterial Agents
R Factors

How can we optimise inhaled beta2 agonist dose as 'reliever' medicine for wheezy pre-school children? Study protocol for a randomised controlled trial

Mukhopadhyay, S., Seddon, P., Earl, G., Wileman, E., Symes, L., Olden, C., Alberti, C., Bremner, S., Lansley, A., Palmer, C. N. A. & Beydon, N. 11 Nov 2016 17

Research output: Contribution to journalArticle

Open Access
File
Albuterol
Randomized Controlled Trials
Medicine
Airway Resistance
Genetic Polymorphisms

Nasal drug delivery

Martin, G. & Lansley, A. 1 Jan 2013 Aulton’s Pharmaceutics: The Design and Manufacture of Medicines (International edition). Edinburgh, p. 657-674 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Endothelin increases the ciliary beat frequency of ovine airway epithelium via its interaction with endothelin a receptors

Pawsey, J., Lansley, A. & Lethem, M. 1 Jun 2011 24, 5, p. 602-609 8 p.

Research output: Contribution to journalArticle

Alcohol ethoxylates mediate their bacteriostatic effect by altering the cell membrane of Escherichia coli NCTC 8196

Moore, S. L., Denyer, S., Hanlon, G., Olliff, C. J., Lansley, A., Rabone, K. & Jones, M. Dec 2006 28, 6, p. 503-513 11 p.

Research output: Contribution to journalArticle

Microbial Sensitivity Tests
Alcohols
Cell Membrane
Escherichia coli
Surface-Active Agents