TY - JOUR
T1 - The Effects of Exercise on Bone Mineral Density in Men
T2 - A Systematic Review and Meta-Analysis of Randomised Controlled Trials
AU - Hamilton, Blair
AU - Staines, Katherine
AU - Kelley, George
AU - Kelley, Kristi
AU - Kohrt, Wendy
AU - Pitsiladis, Yannis
AU - Guppy, Fergus
PY - 2021/8/11
Y1 - 2021/8/11
N2 - The aim of this systematic review and meta-analysis was to provide an updated analysis, including the use of more robust methods, on the effects of exercise on bone mineral density in men. Randomised Control Trials of > 24 weeks and published in English up to 01/05/20 were retrieved from 3 electronic databases, cross-referencing, and expert review. The primary outcome measures were changes in FN, LS, and lower limb BMD Standardised effect sizes were calculated from each study and pooled using the inverse heterogeneity model. A statistically significant benefit of exercise was observed on FN BMD [g = 0.21 (0.03, 0.40), Z = 2.23 p = 0.03], with no observed statistically significant benefit of exercise on LS BMD [g = 0.10 (− 0.07, 0.26), Z = 1.15 p = 0.25]. This analysis provided additional evidence to recommend ground- and/or joint-reaction force exercises for improving or maintaining FN, but not LS BMD. Additional well-designed RCTs are unlikely to alter this evidence, although interventions that include activities that directly load the lumbar spine are needed to ensure this is not a potential method of improving LS BMD.
AB - The aim of this systematic review and meta-analysis was to provide an updated analysis, including the use of more robust methods, on the effects of exercise on bone mineral density in men. Randomised Control Trials of > 24 weeks and published in English up to 01/05/20 were retrieved from 3 electronic databases, cross-referencing, and expert review. The primary outcome measures were changes in FN, LS, and lower limb BMD Standardised effect sizes were calculated from each study and pooled using the inverse heterogeneity model. A statistically significant benefit of exercise was observed on FN BMD [g = 0.21 (0.03, 0.40), Z = 2.23 p = 0.03], with no observed statistically significant benefit of exercise on LS BMD [g = 0.10 (− 0.07, 0.26), Z = 1.15 p = 0.25]. This analysis provided additional evidence to recommend ground- and/or joint-reaction force exercises for improving or maintaining FN, but not LS BMD. Additional well-designed RCTs are unlikely to alter this evidence, although interventions that include activities that directly load the lumbar spine are needed to ensure this is not a potential method of improving LS BMD.
UR - http://www.scopus.com/inward/record.url?scp=85112266795&partnerID=8YFLogxK
U2 - 10.1007/s00223-021-00893-6
DO - 10.1007/s00223-021-00893-6
M3 - Article
SN - 0171-967X
VL - 110
SP - 41
EP - 56
JO - Calcified Tissue International
JF - Calcified Tissue International
IS - 1
ER -