TY - JOUR
T1 - Susceptibility Patterns of Candida spp. Collected from Intensive Care Units
T2 - A Prospective Study in 2020–2022
AU - Nascimento, Teresa
AU - Inacio Silva, Joao
AU - Guerreiro, Daniela
AU - Patrício, Patrícia
AU - Diaz, Priscila
AU - Toscano, Cristina
AU - Faria, Isabel
AU - Barroso, Helena
PY - 2023/8/25
Y1 - 2023/8/25
N2 - The frequency of Candida spp. isolates as a cause of hospital infections has risen, and in vitro antifungal susceptibility testing (AST) plays an increasingly important role in guiding therapeutic decisions. This multicenter study aimed to determine AST pattern of Candida spp. isolates from Intensive Care Unit (ICU) patients. In total, 674 patients were enrolled, and axillar/inguinal swabs were collected at admission and during the ICU stay (5th and 8th day). In vitro AST was performed on 355 Candida spp. isolates, according to the concentration gradient Etest® strip technique. The overall susceptibility rates were 100%, 99.7%, 98.3%, and 97.7% for amphotericin B, voriconazole, anidulafungin, and fluconazole, respectively. The current study demonstrates that antifungal resistance remains infrequent among Candida spp. isolates in Portugal’s ICUs.
AB - The frequency of Candida spp. isolates as a cause of hospital infections has risen, and in vitro antifungal susceptibility testing (AST) plays an increasingly important role in guiding therapeutic decisions. This multicenter study aimed to determine AST pattern of Candida spp. isolates from Intensive Care Unit (ICU) patients. In total, 674 patients were enrolled, and axillar/inguinal swabs were collected at admission and during the ICU stay (5th and 8th day). In vitro AST was performed on 355 Candida spp. isolates, according to the concentration gradient Etest® strip technique. The overall susceptibility rates were 100%, 99.7%, 98.3%, and 97.7% for amphotericin B, voriconazole, anidulafungin, and fluconazole, respectively. The current study demonstrates that antifungal resistance remains infrequent among Candida spp. isolates in Portugal’s ICUs.
KW - Candida spp.
KW - ICUs
KW - Fluconazole
KW - Voriconazole
KW - Amphotericin B
KW - Anidulafungin
KW - resistance
U2 - 10.3390/msf2023022045
DO - 10.3390/msf2023022045
M3 - Article
VL - 22
JO - The 6th International Congress of CiiEM—Immediate and Future Challenges to Foster One Health
JF - The 6th International Congress of CiiEM—Immediate and Future Challenges to Foster One Health
IS - 1
M1 - 45
ER -