Multiple TLRs elicit alternative NLRP3 inflammasome activation in primary human monocytes independent of RIPK1 kinase activity

Pharmacology, Toxicology and Pharmaceutical Science

• Receptor 100%
• Phosphotransferase 100%
• Toll Like Receptor 4 100%
• Protein Kinases 100%
• Inflammasome 100%
• Pyrin 100%
• Nucleotide Binding Oligomerization Domain Like Receptor 100%
• Pyroptosis 80%
• Potassium Ion 60%
• Effusion 60%
• Toll Like Receptor 40%
• Interferon 20%
• Interleukin 1beta Converting Enzyme 20%
• Caspase 8 20%
• Toll Like Receptor 7 20%
• Adaptor Protein 20%
• Toll Like Receptor 8 20%
• Toll Like Receptor 2 20%
• Toll Like Receptor 1 20%

Keyphrases

• Interleukin-1β 100%
• Receptor-interacting Protein Kinase 1 (RIPK1) 100%
• Kinase Activity 100%
• Inflammasome Activation 100%
• Primary Monocytes 100%
• NOD-like Receptor Protein 3 (NLRP3) 100%
• Alternative Pathway 45%
• Gasdermin D (GSDMD) 45%
• Toll-like Receptor 4 (TLR4) 36%
• Pyroptosis 36%
• Monocytes 27%
• Toll-like 27%
• K+ Efflux 27%
• Secondary Signal 18%
• Interferon-α (IFN-α) 9%
• Caspase-1 9%
• Toll-like Receptor 2 (TLR2) 9%
• Pore Formation 9%
• Caspase-8 9%
• Human Support 9%
• TIR Domain 9%
• Toll-like Receptor 8 (TLR8) 9%
• TLR1 9%
• Toll-like Receptor 7 (TLR7) 9%
• Death Domain 9%
• Inflammasome 9%
• Inflammasome Pathway 9%
• Unconventional Secretory Pathway 9%
• Adapter 9%
• Dual-ligand 9%
• Adaptor Protein 9%

Immunology and Microbiology

• Inflammasome 100%