The asymmetric synthesis, spectral properties and incorporation into solid phase peptide synthesis are described for L-(6,7-dimethoxy-4-coumaryl)alanine (Dca). Dca has great utility as a specific and highly sensitive intrinsic probe for fluorescence labelling and quantitation of peptides and proteins.
Bennett, F., Barlow, D. J., Dodoo, A. N. O., Hider, R. C., Lansley, A., Lawrence, J. M., & Marriott, C. (1997). L-(6,7-dimethoxy-4-coumaryl) alanine: an intrinsic probe for the labelling of peptides. Tetrahedron Letters, 38(42), 7449-7452. https://doi.org/10.1016/S0040-4039(97)01753-X