ConStruct 1.0: An R Script to distinguish between substructure and consanguinity within a population using multilocus microsatellite data

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Abstract

ConStruct.1.r is an R Script that estimates the relative contributions of consanguinity and population substructure to excess homozygosity. ConStruct.1.r also offers the option of simulating data with a given FST and magnitude of consanguinity, incorporating a user-specified number of loci, number of alleles and population size. The method seems robust when population sizes are above 200 and individuals are genotyped at greater than 10 loci.
Original languageEnglish
JournalCogent Biology
Volume2
DOIs
Publication statusPublished - 13 Jan 2016

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population size
microsatellite repeats
loci
homozygosity
alleles
methodology

Bibliographical note

© 2016 The Author(s). This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license.

Keywords

  • R Script
  • consanguinity
  • population substructure
  • microsatellites
  • FST

Cite this

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abstract = "ConStruct.1.r is an R Script that estimates the relative contributions of consanguinity and population substructure to excess homozygosity. ConStruct.1.r also offers the option of simulating data with a given FST and magnitude of consanguinity, incorporating a user-specified number of loci, number of alleles and population size. The method seems robust when population sizes are above 200 and individuals are genotyped at greater than 10 loci.",
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author = "Andrew Overall",
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AB - ConStruct.1.r is an R Script that estimates the relative contributions of consanguinity and population substructure to excess homozygosity. ConStruct.1.r also offers the option of simulating data with a given FST and magnitude of consanguinity, incorporating a user-specified number of loci, number of alleles and population size. The method seems robust when population sizes are above 200 and individuals are genotyped at greater than 10 loci.

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