ConStruct.1.r is an R Script that estimates the relative contributions of consanguinity and population substructure to excess homozygosity. ConStruct.1.r also offers the option of simulating data with a given FST and magnitude of consanguinity, incorporating a user-specified number of loci, number of alleles and population size. The method seems robust when population sizes are above 200 and individuals are genotyped at greater than 10 loci.
Bibliographical note© 2016 The Author(s). This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license.
- R Script
- population substructure
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- School of Applied Sciences - Senior Lecturer
- Ecology, Conservation and Zoonosis Research and Enterprise Group