ConStruct 1.0: An R Script to distinguish between substructure and consanguinity within a population using multilocus microsatellite data

Andrew Overall

doi:10.1080/23312025.2015.1128317

ConStruct 1.0: An R Script to distinguish between substructure and consanguinity within a population using multilocus microsatellite data

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Abstract

ConStruct.1.r is an R Script that estimates the relative contributions of consanguinity and population substructure to excess homozygosity. ConStruct.1.r also offers the option of simulating data with a given FST and magnitude of consanguinity, incorporating a user-specified number of loci, number of alleles and population size. The method seems robust when population sizes are above 200 and individuals are genotyped at greater than 10 loci.

Original language	English
Journal	Cogent Biology
Volume	2
DOIs	https://doi.org/10.1080/23312025.2015.1128317
Publication status	Published - 13 Jan 2016

Bibliographical note

Keywords

R Script
consanguinity
population substructure
microsatellites
FST

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Andrew Overall
- A.D.J.Overallbrighton.acuk
Person: Academic

Cite this

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abstract = "ConStruct.1.r is an R Script that estimates the relative contributions of consanguinity and population substructure to excess homozygosity. ConStruct.1.r also offers the option of simulating data with a given FST and magnitude of consanguinity, incorporating a user-specified number of loci, number of alleles and population size. The method seems robust when population sizes are above 200 and individuals are genotyped at greater than 10 loci.",

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KW - R Script

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KW - population substructure

KW - microsatellites

KW - FST

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JO - Cogent Biology

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ConStruct 1.0: An R Script to distinguish between substructure and consanguinity within a population using multilocus microsatellite data

Abstract

Bibliographical note

Keywords

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Andrew Overall

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