Bacterial biofilm formation on indwelling urethral catheters

H. Pelling, Jonathan Nzakizwanayo, S. Milo, E.L. Denham, Wendy Macfarlane, L.J. Bock, J.M. Sutton, Brian Jones

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Urethral catheters are the most commonly deployed medical devices and used to manage a wide range of conditions in both hospital and community care settings. The use of long-term catheterization, where the catheter remains in place for a period >28 days remains common, and the care of these patients is often undermined by the acquisition of infections and formation of biofilms on catheter surfaces. Particular problems arise from colonization with urease-producing species such as Proteus mirabilis, which form unusual crystalline biofilms that encrust catheter surfaces and block urine flow. Encrustation and blockage often lead to a range of serious clinical complications and emergency hospital referrals in long-term catheterized patients. Here we review current understanding of bacterial biofilm formation on urethral catheters, with a focus on crystalline biofilm formation by P. mirabilis, as well as approaches that may be used to control biofilm formation on these devices. Significance and Impact of the Study: Urinary catheters are the most commonly used medical devices in many healthcare systems, but their use predisposes to infection and provide ideal conditions for bacterial biofilm formation. Patients managed by long-term urethral catheterization are particularly vulnerable to biofilm-related infections, with crystalline biofilm formation by urease producing species frequently leading to catheter blockage and other serious clinical complications. This review considers current knowledge regarding biofilm formation on urethral catheters, and possible strategies for their control.

Original languageEnglish
Pages (from-to)277-293
Number of pages17
JournalLetters in Applied Microbiology
Volume68
Issue number4
DOIs
Publication statusPublished - 27 Feb 2019

Fingerprint

Urinary Catheters
Indwelling Catheters
Biofilms
Catheters
Proteus mirabilis
Urease
Equipment and Supplies
Infection
Urinary Catheterization
Catheterization
Patient Care
Emergencies
Referral and Consultation
Urine
Delivery of Health Care

Bibliographical note

This is the peer reviewed version of the following article: Pelling, H. , Nzakizwanayo, J. , Milo, S. , Denham, E. L., MacFarlane, W. M., Bock, L. J., Sutton, J. M. and Jones, B. V. (2019), Bacterial biofilm formation on indwelling urethral catheters. Lett Appl Microbiol., which has been published in final form at https://onlinelibrary.wiley.com/doi/10.1111/lam.13144. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

Keywords

  • Biofilms
  • Disease processes
  • Diseases
  • resistance
  • Virulence

Cite this

Pelling, H., Nzakizwanayo, J., Milo, S., Denham, E. L., Macfarlane, W., Bock, L. J., ... Jones, B. (2019). Bacterial biofilm formation on indwelling urethral catheters. Letters in Applied Microbiology, 68(4), 277-293. https://doi.org/10.1111/lam.13144
Pelling, H. ; Nzakizwanayo, Jonathan ; Milo, S. ; Denham, E.L. ; Macfarlane, Wendy ; Bock, L.J. ; Sutton, J.M. ; Jones, Brian. / Bacterial biofilm formation on indwelling urethral catheters. In: Letters in Applied Microbiology. 2019 ; Vol. 68, No. 4. pp. 277-293.
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Pelling, H, Nzakizwanayo, J, Milo, S, Denham, EL, Macfarlane, W, Bock, LJ, Sutton, JM & Jones, B 2019, 'Bacterial biofilm formation on indwelling urethral catheters', Letters in Applied Microbiology, vol. 68, no. 4, pp. 277-293. https://doi.org/10.1111/lam.13144

Bacterial biofilm formation on indwelling urethral catheters. / Pelling, H.; Nzakizwanayo, Jonathan; Milo, S.; Denham, E.L.; Macfarlane, Wendy; Bock, L.J.; Sutton, J.M.; Jones, Brian.

In: Letters in Applied Microbiology, Vol. 68, No. 4, 27.02.2019, p. 277-293.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Bock, L.J.

AU - Sutton, J.M.

AU - Jones, Brian

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Pelling H, Nzakizwanayo J, Milo S, Denham EL, Macfarlane W, Bock LJ et al. Bacterial biofilm formation on indwelling urethral catheters. Letters in Applied Microbiology. 2019 Feb 27;68(4):277-293. https://doi.org/10.1111/lam.13144