The coronavirus disease 2019 (COVID-19) is a vaccine-preventable disease amongst all ages; however, parental attitudes, perceptions and concerns towards children’s vaccination can hamper immunization efforts and leave this vulnerable group of the society unprotected. The aim of this study is to assess the attitude, perception and concern towards children’s vaccination amidst the COVID-19 Pandemic among selected workers in a Nigerian population. Methods: This web-based study was conducted among a selected Nigerian population between the month of February and May 2021 using an online self-administered structured questionnaire hosted by Survey Monkey. The invitation to take part in the poll was sent out to a total of 180 persons through social networking platforms including Facebook, Twitter, and WhatsApp. Version 25 of the Statistical Package for the Social Sciences (SPSS) was used to analyze the data collected and results presented using tables, bar charts and pie charts. The cutoff point was established at a level of significance equal to P < 0.05. Results: Vaccine hesitant score on childhood acceptance rates shows that 28 (15.6%) had low acceptance rates, 125 (69.4%) had moderate acceptance rates, and 27 (15.0%) had high acceptance rates. There was significant association between age and overall vaccine hesitance on children’s vaccination acceptance rates at χ2 = 16.804, P = 0.032. Conclusion: More than two-thirds of study participants supported children's vaccination. Those with low compliance may lack a realistic perception of infection risk, poor-quality information about immunizations and the disease, and general understanding.