ARDD 2020: from aging mechanisms to interventions

Garik V. Mkrtchyan; Kotb Abdelmohsen; Pénélope Andreux; Ieva Bagdonaite; Nir Barzilai; Søren Brunak; Filipe Cabreiro; Rafael de Cabo; Judith Campisi; Ana Maria Cuervo; Marсo Demaria; Collin Y. Ewald; Evandro Fei Fang; Richard Faragher; Luigi Ferrucci; Adam Freund; Carlos G. Silva-García; Anastasia Georgievskaya; Vadim N. Gladyshev; David J. Glass; Vera Gorbunova; Aubrey de Grey; Wei Wu He; Jan Hoeijmakers; Eva Hoffmann; Steve Horvath; Riekelt H. Houtkooper; Majken K. Jensen; Martin Borch Jensen; Alice Kane; Moustapha Kassem; Peter de Keizer; Brian Kennedy; Gerard Karsenty; Dudley W. Lamming; Kai Fu Lee; Nanna MacAulay; Polina Mamoshina; Jim Mellon; Marte Molenaars; Alexey Moskalev; Andreas Mund; Laura Niedernhofer; Brenna Osborne; Heidi H. Pak; Andrey Parkhitko; Nuno Raimundo; Thomas A. Rando; Lene Juel Rasmussen; Carolina Reis; Christian G. Riedel; Anais Franco-Romero; Björn Schumacher; David A. Sinclair; Yousin Suh; Pam R. Taub; Debra Toiber; Jonas T. Treebak; Dario Riccardo Valenzano; Eric Verdin; Jan Vijg; Sergey Young; Lei Zhang; Daniela Bakula; Alex Zhavoronkov; Morten Scheibye-Knudsen

doi:10.18632/aging.202454

ARDD 2020: from aging mechanisms to interventions

Garik V. Mkrtchyan, Kotb Abdelmohsen, Pénélope Andreux, Ieva Bagdonaite, Nir Barzilai, Søren Brunak, Filipe Cabreiro, Rafael de Cabo, Judith Campisi, Ana Maria Cuervo, Marсo Demaria, Collin Y. Ewald, Evandro Fei Fang, Richard Faragher, Luigi Ferrucci, Adam Freund, Carlos G. Silva-García, Anastasia Georgievskaya, Vadim N. Gladyshev, David J. GlassVera Gorbunova, Aubrey de Grey, Wei Wu He, Jan Hoeijmakers, Eva Hoffmann, Steve Horvath, Riekelt H. Houtkooper, Majken K. Jensen, Martin Borch Jensen, Alice Kane, Moustapha Kassem, Peter de Keizer, Brian Kennedy, Gerard Karsenty, Dudley W. Lamming, Kai Fu Lee, Nanna MacAulay, Polina Mamoshina, Jim Mellon, Marte Molenaars, Alexey Moskalev, Andreas Mund, Laura Niedernhofer, Brenna Osborne, Heidi H. Pak, Andrey Parkhitko, Nuno Raimundo, Thomas A. Rando, Lene Juel Rasmussen, Carolina Reis, Christian G. Riedel, Anais Franco-Romero, Björn Schumacher, David A. Sinclair, Yousin Suh, Pam R. Taub, Debra Toiber, Jonas T. Treebak, Dario Riccardo Valenzano, Eric Verdin, Jan Vijg, Sergey Young, Lei Zhang, Daniela Bakula, Alex Zhavoronkov, Morten Scheibye-Knudsen

University of Brighton

Research output: Contribution to journal › Article › peer-review

Abstract

Aging is emerging as a druggable target with growing interest from academia, industry and investors. New technologies such as artificial intelligence and advanced screening techniques, as well as a strong influence from the industry sector may lead to novel discoveries to treat age-related diseases. The present review summarizes presentations from the 7^th Annual Aging Research and Drug Discovery (ARDD) meeting, held online on the 1^st to 4^th of September 2020. The meeting covered topics related to new methodologies to study aging, knowledge about basic mechanisms of longevity, latest interventional strategies to target the aging process as well as discussions about the impact of aging research on society and economy. More than 2000 participants and 65 speakers joined the meeting and we already look forward to an even larger meeting next year. Please mark your calendars for the 8^th ARDD meeting that is scheduled for the 31^st of August to 3^rd of September, 2021, at Columbia University, USA.

Original language	English
Pages (from-to)	24486-24503
Number of pages	18
Journal	Aging
Volume	12
Issue number	24
DOIs	https://doi.org/10.18632/aging.202454
Publication status	Published - 30 Dec 2020

Bibliographical note

Funding Information:
S.B. is supported by the Novo Nordisk Foundation (grants NNF17OC0027594 and NNF14CC0001). F.C. acknowledges funding from the Wellcome Trust/Royal Society (102532/Z/12/Z and 102531/Z/13/A). A.M.C is supported in part by grants from JPB and Rainwaters Foundation. C.G.S.G. is funded by the NIH/NIA (K99AG065508). E.F.F. is supported by HELSE SØR-ØST (#2017056), the Research Council of Norway (#262175 and #277813), the National Natural Science Foundation of China (#81971327), an Akershus University Hospital Strategic grant (#269901), and a Rosa Sløyfe grant (#207819) from the Norwegian Cancer Society. V.N.G. is supported by grants from the National Institute on Aging. D.W.L. is supported in part by research grants and funds from the National Institutes of Health (AG041765, AG050135, AG051974, AG056771 and AG062328), the Wisconsin Partnership Program, the Progeria Research Foundation, the American Federation for Aging Research, and the University of Wisconsin-Madison School of Medicine and Public Health and Department of Medicine. The Lamming laboratory is supported in part by the U.S. Department of Veterans Affairs (I01-BX004031), and this work was supported using facilities and resources from the William S. Middleton Memorial Veterans Hospital. H.H.P. is supported by a NIA F31 predoctoral fellowship (NIA F31 AG066311). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. This work does not represent the views of the Department of Veterans Affairs or the United States Government. JTT is supported by the Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR). CBMR is an independent Research Center at the University of Copenhagen and partially funded by an unrestricted donation from the Novo Nordisk Foundation (NNF18CC0034900). L.N. is funded by NIH/NIA (R01 AG063543-02S1). L.Z. work is funded by NIH/NIA (U19 AG056278 and P01 AG062412). L.J.R is supported by research grants from Nordea-fonden, Olav Thon Foundation, Novo Nordisk Foundation (NNF17OC0027812). L.J.R. is a member of the Clinical Academic Group: Recovery Capacity After Acute Illness in And Aging Population (RECAP). C.G.R. is supported by the Swedish Research Council (VR) grants (2015-03740, 2017-06088, and 2019-04868), the COST grant BM1408 (GENiE), and an ICMC project grant. D.T. work is funded by The David and Inez Myers foundation and ISF 188/17. D.A.S is supported by the Harvard Medical School Epigenetics Seed Grant and Development Grant, The Paul F. Glenn Foundation for Medical Research, and NIH awards (R01AG019719 and R37AG028730). B.S. acknowledges funding from the Deutsche Forschungsgemeinschaft (SCHU 2494/3-1, SCHU 2494/7-1, SCHU 2494/10-1, SCHU 2494/11-1, CECAD, SFB 829, KFO 286, KFO 329, and GRK2407), the Deutsche Krebshilfe (70112899), and the H2020-MSCA-ITN-2018 (Healthage and ADDRESS ITNs). D.B. is supported by the Lundbeck foundation (# R303-2018-3159). M.S.K. is funded through the Nordea Foundation (#02-2017-1749), the Novo Nordisk Foundation (#NNF17OC0027812), the Neye Foundation, the Lundbeck Foundation (#R324-2019-1492), the Ministry of Higher Education and Science (#0238-00003B) and Insilico Medicine.

Publisher Copyright:
© 2020. Mkrtchyan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. All Rights Reserved.

Keywords

aging
artificial intelligence
drug discovery
interventions

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10.18632/aging.202454Licence: CC BY

Cite this

Mkrtchyan, G. V., Abdelmohsen, K., Andreux, P., Bagdonaite, I., Barzilai, N., Brunak, S., Cabreiro, F., Cabo, R. D., Campisi, J., Cuervo, A. M., Demaria, M., Ewald, C. Y., Fang, E. F., Faragher, R., Ferrucci, L., Freund, A., Silva-García, C. G., Georgievskaya, A., Gladyshev, V. N., ... Scheibye-Knudsen, M. (2020). ARDD 2020: from aging mechanisms to interventions. Aging, 12(24), 24486-24503. https://doi.org/10.18632/aging.202454

@article{e82b7a9c4fde4527a7328ecbac00055a,

title = "ARDD 2020: from aging mechanisms to interventions",

abstract = "Aging is emerging as a druggable target with growing interest from academia, industry and investors. New technologies such as artificial intelligence and advanced screening techniques, as well as a strong influence from the industry sector may lead to novel discoveries to treat age-related diseases. The present review summarizes presentations from the 7th Annual Aging Research and Drug Discovery (ARDD) meeting, held online on the 1st to 4th of September 2020. The meeting covered topics related to new methodologies to study aging, knowledge about basic mechanisms of longevity, latest interventional strategies to target the aging process as well as discussions about the impact of aging research on society and economy. More than 2000 participants and 65 speakers joined the meeting and we already look forward to an even larger meeting next year. Please mark your calendars for the 8th ARDD meeting that is scheduled for the 31st of August to 3rd of September, 2021, at Columbia University, USA.",

keywords = "aging, artificial intelligence, drug discovery, interventions",

author = "Mkrtchyan, {Garik V.} and Kotb Abdelmohsen and P{\'e}n{\'e}lope Andreux and Ieva Bagdonaite and Nir Barzilai and S{\o}ren Brunak and Filipe Cabreiro and Cabo, {Rafael de} and Judith Campisi and Cuervo, {Ana Maria} and Marсo Demaria and Ewald, {Collin Y.} and Fang, {Evandro Fei} and Richard Faragher and Luigi Ferrucci and Adam Freund and Silva-Garc{\'i}a, {Carlos G.} and Anastasia Georgievskaya and Gladyshev, {Vadim N.} and Glass, {David J.} and Vera Gorbunova and Grey, {Aubrey de} and He, {Wei Wu} and Jan Hoeijmakers and Eva Hoffmann and Steve Horvath and Houtkooper, {Riekelt H.} and Jensen, {Majken K.} and Jensen, {Martin Borch} and Alice Kane and Moustapha Kassem and Keizer, {Peter de} and Brian Kennedy and Gerard Karsenty and Lamming, {Dudley W.} and Lee, {Kai Fu} and Nanna MacAulay and Polina Mamoshina and Jim Mellon and Marte Molenaars and Alexey Moskalev and Andreas Mund and Laura Niedernhofer and Brenna Osborne and Pak, {Heidi H.} and Andrey Parkhitko and Nuno Raimundo and Rando, {Thomas A.} and Rasmussen, {Lene Juel} and Carolina Reis and Riedel, {Christian G.} and Anais Franco-Romero and Bj{\"o}rn Schumacher and Sinclair, {David A.} and Yousin Suh and Taub, {Pam R.} and Debra Toiber and Treebak, {Jonas T.} and Valenzano, {Dario Riccardo} and Eric Verdin and Jan Vijg and Sergey Young and Lei Zhang and Daniela Bakula and Alex Zhavoronkov and Morten Scheibye-Knudsen",

note = "Funding Information: S.B. is supported by the Novo Nordisk Foundation (grants NNF17OC0027594 and NNF14CC0001). F.C. acknowledges funding from the Wellcome Trust/Royal Society (102532/Z/12/Z and 102531/Z/13/A). A.M.C is supported in part by grants from JPB and Rainwaters Foundation. C.G.S.G. is funded by the NIH/NIA (K99AG065508). E.F.F. is supported by HELSE S{\O}R-{\O}ST (#2017056), the Research Council of Norway (#262175 and #277813), the National Natural Science Foundation of China (#81971327), an Akershus University Hospital Strategic grant (#269901), and a Rosa Sl{\o}yfe grant (#207819) from the Norwegian Cancer Society. V.N.G. is supported by grants from the National Institute on Aging. D.W.L. is supported in part by research grants and funds from the National Institutes of Health (AG041765, AG050135, AG051974, AG056771 and AG062328), the Wisconsin Partnership Program, the Progeria Research Foundation, the American Federation for Aging Research, and the University of Wisconsin-Madison School of Medicine and Public Health and Department of Medicine. The Lamming laboratory is supported in part by the U.S. Department of Veterans Affairs (I01-BX004031), and this work was supported using facilities and resources from the William S. Middleton Memorial Veterans Hospital. H.H.P. is supported by a NIA F31 predoctoral fellowship (NIA F31 AG066311). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. This work does not represent the views of the Department of Veterans Affairs or the United States Government. JTT is supported by the Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR). CBMR is an independent Research Center at the University of Copenhagen and partially funded by an unrestricted donation from the Novo Nordisk Foundation (NNF18CC0034900). L.N. is funded by NIH/NIA (R01 AG063543-02S1). L.Z. work is funded by NIH/NIA (U19 AG056278 and P01 AG062412). L.J.R is supported by research grants from Nordea-fonden, Olav Thon Foundation, Novo Nordisk Foundation (NNF17OC0027812). L.J.R. is a member of the Clinical Academic Group: Recovery Capacity After Acute Illness in And Aging Population (RECAP). C.G.R. is supported by the Swedish Research Council (VR) grants (2015-03740, 2017-06088, and 2019-04868), the COST grant BM1408 (GENiE), and an ICMC project grant. D.T. work is funded by The David and Inez Myers foundation and ISF 188/17. D.A.S is supported by the Harvard Medical School Epigenetics Seed Grant and Development Grant, The Paul F. Glenn Foundation for Medical Research, and NIH awards (R01AG019719 and R37AG028730). B.S. acknowledges funding from the Deutsche Forschungsgemeinschaft (SCHU 2494/3-1, SCHU 2494/7-1, SCHU 2494/10-1, SCHU 2494/11-1, CECAD, SFB 829, KFO 286, KFO 329, and GRK2407), the Deutsche Krebshilfe (70112899), and the H2020-MSCA-ITN-2018 (Healthage and ADDRESS ITNs). D.B. is supported by the Lundbeck foundation (# R303-2018-3159). M.S.K. is funded through the Nordea Foundation (#02-2017-1749), the Novo Nordisk Foundation (#NNF17OC0027812), the Neye Foundation, the Lundbeck Foundation (#R324-2019-1492), the Ministry of Higher Education and Science (#0238-00003B) and Insilico Medicine. Publisher Copyright: {\textcopyright} 2020. Mkrtchyan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. All Rights Reserved.",

year = "2020",

month = dec,

day = "30",

doi = "10.18632/aging.202454",

language = "English",

volume = "12",

pages = "24486--24503",

number = "24",

}

Mkrtchyan, GV, Abdelmohsen, K, Andreux, P, Bagdonaite, I, Barzilai, N, Brunak, S, Cabreiro, F, Cabo, RD, Campisi, J, Cuervo, AM, Demaria, M, Ewald, CY, Fang, EF, Faragher, R, Ferrucci, L, Freund, A, Silva-García, CG, Georgievskaya, A, Gladyshev, VN, Glass, DJ, Gorbunova, V, Grey, AD, He, WW, Hoeijmakers, J, Hoffmann, E, Horvath, S, Houtkooper, RH, Jensen, MK, Jensen, MB, Kane, A, Kassem, M, Keizer, PD, Kennedy, B, Karsenty, G, Lamming, DW, Lee, KF, MacAulay, N, Mamoshina, P, Mellon, J, Molenaars, M, Moskalev, A, Mund, A, Niedernhofer, L, Osborne, B, Pak, HH, Parkhitko, A, Raimundo, N, Rando, TA, Rasmussen, LJ, Reis, C, Riedel, CG, Franco-Romero, A, Schumacher, B, Sinclair, DA, Suh, Y, Taub, PR, Toiber, D, Treebak, JT, Valenzano, DR, Verdin, E, Vijg, J, Young, S, Zhang, L, Bakula, D, Zhavoronkov, A & Scheibye-Knudsen, M 2020, 'ARDD 2020: from aging mechanisms to interventions', Aging, vol. 12, no. 24, pp. 24486-24503. https://doi.org/10.18632/aging.202454

TY - JOUR

T1 - ARDD 2020

T2 - from aging mechanisms to interventions

AU - Mkrtchyan, Garik V.

AU - Abdelmohsen, Kotb

AU - Andreux, Pénélope

AU - Bagdonaite, Ieva

AU - Barzilai, Nir

AU - Brunak, Søren

AU - Cabreiro, Filipe

AU - Cabo, Rafael de

AU - Campisi, Judith

AU - Cuervo, Ana Maria

AU - Demaria, Marсo

AU - Ewald, Collin Y.

AU - Fang, Evandro Fei

AU - Faragher, Richard

AU - Ferrucci, Luigi

AU - Freund, Adam

AU - Silva-García, Carlos G.

AU - Georgievskaya, Anastasia

AU - Gladyshev, Vadim N.

AU - Glass, David J.

AU - Gorbunova, Vera

AU - Grey, Aubrey de

AU - He, Wei Wu

AU - Hoeijmakers, Jan

AU - Hoffmann, Eva

AU - Horvath, Steve

AU - Houtkooper, Riekelt H.

AU - Jensen, Majken K.

AU - Jensen, Martin Borch

AU - Kane, Alice

AU - Kassem, Moustapha

AU - Keizer, Peter de

AU - Kennedy, Brian

AU - Karsenty, Gerard

AU - Lamming, Dudley W.

AU - Lee, Kai Fu

AU - MacAulay, Nanna

AU - Mamoshina, Polina

AU - Mellon, Jim

AU - Molenaars, Marte

AU - Moskalev, Alexey

AU - Mund, Andreas

AU - Niedernhofer, Laura

AU - Osborne, Brenna

AU - Pak, Heidi H.

AU - Parkhitko, Andrey

AU - Raimundo, Nuno

AU - Rando, Thomas A.

AU - Rasmussen, Lene Juel

AU - Reis, Carolina

AU - Riedel, Christian G.

AU - Franco-Romero, Anais

AU - Schumacher, Björn

AU - Sinclair, David A.

AU - Suh, Yousin

AU - Taub, Pam R.

AU - Toiber, Debra

AU - Treebak, Jonas T.

AU - Valenzano, Dario Riccardo

AU - Verdin, Eric

AU - Vijg, Jan

AU - Young, Sergey

AU - Zhang, Lei

AU - Bakula, Daniela

AU - Zhavoronkov, Alex

AU - Scheibye-Knudsen, Morten

N1 - Funding Information: S.B. is supported by the Novo Nordisk Foundation (grants NNF17OC0027594 and NNF14CC0001). F.C. acknowledges funding from the Wellcome Trust/Royal Society (102532/Z/12/Z and 102531/Z/13/A). A.M.C is supported in part by grants from JPB and Rainwaters Foundation. C.G.S.G. is funded by the NIH/NIA (K99AG065508). E.F.F. is supported by HELSE SØR-ØST (#2017056), the Research Council of Norway (#262175 and #277813), the National Natural Science Foundation of China (#81971327), an Akershus University Hospital Strategic grant (#269901), and a Rosa Sløyfe grant (#207819) from the Norwegian Cancer Society. V.N.G. is supported by grants from the National Institute on Aging. D.W.L. is supported in part by research grants and funds from the National Institutes of Health (AG041765, AG050135, AG051974, AG056771 and AG062328), the Wisconsin Partnership Program, the Progeria Research Foundation, the American Federation for Aging Research, and the University of Wisconsin-Madison School of Medicine and Public Health and Department of Medicine. The Lamming laboratory is supported in part by the U.S. Department of Veterans Affairs (I01-BX004031), and this work was supported using facilities and resources from the William S. Middleton Memorial Veterans Hospital. H.H.P. is supported by a NIA F31 predoctoral fellowship (NIA F31 AG066311). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. This work does not represent the views of the Department of Veterans Affairs or the United States Government. JTT is supported by the Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR). CBMR is an independent Research Center at the University of Copenhagen and partially funded by an unrestricted donation from the Novo Nordisk Foundation (NNF18CC0034900). L.N. is funded by NIH/NIA (R01 AG063543-02S1). L.Z. work is funded by NIH/NIA (U19 AG056278 and P01 AG062412). L.J.R is supported by research grants from Nordea-fonden, Olav Thon Foundation, Novo Nordisk Foundation (NNF17OC0027812). L.J.R. is a member of the Clinical Academic Group: Recovery Capacity After Acute Illness in And Aging Population (RECAP). C.G.R. is supported by the Swedish Research Council (VR) grants (2015-03740, 2017-06088, and 2019-04868), the COST grant BM1408 (GENiE), and an ICMC project grant. D.T. work is funded by The David and Inez Myers foundation and ISF 188/17. D.A.S is supported by the Harvard Medical School Epigenetics Seed Grant and Development Grant, The Paul F. Glenn Foundation for Medical Research, and NIH awards (R01AG019719 and R37AG028730). B.S. acknowledges funding from the Deutsche Forschungsgemeinschaft (SCHU 2494/3-1, SCHU 2494/7-1, SCHU 2494/10-1, SCHU 2494/11-1, CECAD, SFB 829, KFO 286, KFO 329, and GRK2407), the Deutsche Krebshilfe (70112899), and the H2020-MSCA-ITN-2018 (Healthage and ADDRESS ITNs). D.B. is supported by the Lundbeck foundation (# R303-2018-3159). M.S.K. is funded through the Nordea Foundation (#02-2017-1749), the Novo Nordisk Foundation (#NNF17OC0027812), the Neye Foundation, the Lundbeck Foundation (#R324-2019-1492), the Ministry of Higher Education and Science (#0238-00003B) and Insilico Medicine. Publisher Copyright: © 2020. Mkrtchyan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. All Rights Reserved.

PY - 2020/12/30

Y1 - 2020/12/30

N2 - Aging is emerging as a druggable target with growing interest from academia, industry and investors. New technologies such as artificial intelligence and advanced screening techniques, as well as a strong influence from the industry sector may lead to novel discoveries to treat age-related diseases. The present review summarizes presentations from the 7th Annual Aging Research and Drug Discovery (ARDD) meeting, held online on the 1st to 4th of September 2020. The meeting covered topics related to new methodologies to study aging, knowledge about basic mechanisms of longevity, latest interventional strategies to target the aging process as well as discussions about the impact of aging research on society and economy. More than 2000 participants and 65 speakers joined the meeting and we already look forward to an even larger meeting next year. Please mark your calendars for the 8th ARDD meeting that is scheduled for the 31st of August to 3rd of September, 2021, at Columbia University, USA.

AB - Aging is emerging as a druggable target with growing interest from academia, industry and investors. New technologies such as artificial intelligence and advanced screening techniques, as well as a strong influence from the industry sector may lead to novel discoveries to treat age-related diseases. The present review summarizes presentations from the 7th Annual Aging Research and Drug Discovery (ARDD) meeting, held online on the 1st to 4th of September 2020. The meeting covered topics related to new methodologies to study aging, knowledge about basic mechanisms of longevity, latest interventional strategies to target the aging process as well as discussions about the impact of aging research on society and economy. More than 2000 participants and 65 speakers joined the meeting and we already look forward to an even larger meeting next year. Please mark your calendars for the 8th ARDD meeting that is scheduled for the 31st of August to 3rd of September, 2021, at Columbia University, USA.

KW - aging

KW - artificial intelligence

KW - drug discovery

KW - interventions

UR - http://www.scopus.com/inward/record.url?scp=85098933913&partnerID=8YFLogxK

U2 - 10.18632/aging.202454

DO - 10.18632/aging.202454

M3 - Article

C2 - 33378272

AN - SCOPUS:85098933913

SN - 1945-4589

VL - 12

SP - 24486

EP - 24503

JO - Aging

JF - Aging

IS - 24

ER -

ARDD 2020: from aging mechanisms to interventions

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Keywords

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