Activated carbon-plasticised agarose composite films for the adsorption of thiol as a model of wound malodour

Matthew Illsley, A. Akhmetova, Cressida Bowyer, T. Nurgozhin, Sergey Mikhalovsky, J. Farrer, Peter Dubruel, Iain Allan

Research output: Contribution to journalArticle

Abstract

Conditions such as diabetes, cardiovascular disease and long-term immobilisation can precipitate the development of chronic dermal ulcers. Such wounds are associated with inflammation and bacterial contamination which in turn can lead to the liberation of offensive odours that cause patient embarrassment and, in some instances, social isolation. Activated carbon-containing dressings have been used to manage the odours from such wounds. However, these can be bulky and can become fouled by wound exudate. Agarose is a natural polysaccharide derived from seaweed that forms brittle free-standing films that can be made pliable by addition of a plasticiser. In this study, activated carboncontaining plasticised agarose films were evaluated for their ability to sequester thiol-containing molecules from solution and the gaseous phase. The water vapour transmission rate was also evaluated to determine the potential breathability of these films should they be considered for application to the skin. It was found that the adsorption of thiols was directly proportional to the activated carbon content of the films. Water vapour was found to pass relatively freely through the films indicating that sweat-induced tissue maceration would be unlikely to occur if applied clinically. In conclusion, activated carbon-containing plasticised agarose films have some potential in the sequestration of malodourous molecules such as those liberated from chronic dermal wounds.
Original languageEnglish
JournalJournal of Materials Science: Materials in Medicine
Volume28
Issue number10
DOIs
Publication statusPublished - 1 Sep 2017

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Sulfhydryl Compounds
Sepharose
Adsorption
Carbon
Steam
Wounds and Injuries
Skin Ulcer
Plasticizers
Seaweed
Social Isolation
Skin
Aptitude
Sweat
Exudates and Transudates
Bandages
Immobilization
Polysaccharides
Cardiovascular Diseases
Inflammation
Odorants

Bibliographical note

This is a post-peer-review, pre-copyedit version of an article published in Journal of Materials Science: Materials in Medicine. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10856-017-5964-x

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Illsley, Matthew ; Akhmetova, A. ; Bowyer, Cressida ; Nurgozhin, T. ; Mikhalovsky, Sergey ; Farrer, J. ; Dubruel, Peter ; Allan, Iain. / Activated carbon-plasticised agarose composite films for the adsorption of thiol as a model of wound malodour. In: Journal of Materials Science: Materials in Medicine. 2017 ; Vol. 28, No. 10.
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Activated carbon-plasticised agarose composite films for the adsorption of thiol as a model of wound malodour. / Illsley, Matthew; Akhmetova, A.; Bowyer, Cressida; Nurgozhin, T.; Mikhalovsky, Sergey; Farrer, J.; Dubruel, Peter; Allan, Iain.

In: Journal of Materials Science: Materials in Medicine, Vol. 28, No. 10, 01.09.2017.

Research output: Contribution to journalArticle

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AU - Illsley, Matthew

AU - Akhmetova, A.

AU - Bowyer, Cressida

AU - Nurgozhin, T.

AU - Mikhalovsky, Sergey

AU - Farrer, J.

AU - Dubruel, Peter

AU - Allan, Iain

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