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Personal profile

Scholarly biography

Dr Angela Sheerin is a senior lecturer in the School of Pharmacy and Biomolecular Sciences. After joining the University of Brighton as a Research Fellow in 2000, I fostered a deep interest in ageing and senescence. This has since influenced my research in the fields of impact of senescence on ageing disorders, cerebral amyloid angiopathy (CAA), ophthalmology, micro-organisms and chronic obstructive pulmonary disease (COPD).

My first degree is in biochemistry (BSc (Hons) sandwich) from the University of East London. I did my PhD in molecular gerontology; Investigation of the composition of AP-1 during ageing. I came to the University of Brighton in 2000 as a research fellow and now lecture in the field of molecular biology, pathobiology, medical genetics, endocrinology and biochemistry.

Currently she has a few areas she is working in, they are varied but have a theme of ageing, cell biology and or the eye behind them. She works in collaboration with a number of colleagues in PABS to strengthen her knowledge and skills base. Current themes are; Ageing as a risk factor for chronic obstructive pulmonary disease (COPD) and the effects that senescent cells may have or contribute to in the disease; Small molecules, often found in the diet, that can modulate pathways involved in cellular senescence; Klebsiella pneumonia, a human pathogen that can cause ophthalmic infections, and its bacteremia properties.

Outside of my research and teaching I am the founder and organiser of ‘A* scientist’. This is an outreach program that introduces 'hands on' science to primary schools in Sussex.

Roles

  • Course leader MRES Biosciences
  • Module leader on the biosciences degree programmes.
  • Tissue culture manager
  • Biological safety officer (BSO)
  • Member of the safety committee
  • Chair of the genetically modified organism’s safety committee(GMSC)
  • Member of the editorial board for the rejuvenation research journal.
  • Founder of A* Science outreach programme for primary school children
  • Reviewer of grant applications for BBSRC, SPARC and Research Into Ageing.
  • Reviewer of papers for scientific journals.
  • STEM ambassador
  • Nuffield summer placement provider (2013-present)
  • Salters festival of chemistry judge (2012-present)

Approach to teaching

I am course leader for the MRES biosciences course and a senior lecturer of the biosciences teaching team for undergraduates studying biomedical science, biological science and ecology. I lecture in the area of molecular biology, cell biology, pathobiology, medical genetics, endocrinology, ageing and biochemistry. I am an enthusiastic lecturer who likes to use new and modern technologies to translate knowledge to the students.

I believe in 'hands on' practical experience as well as interactive learning through lectures, blended learning and flip learning. I use a lot of animation, videos and pod casts in my lectures to help give a wider choice of learning material. I expect my students to explore the topic area with the extended reading given in the sessions using both primary and secondary sources.

I want my students to engage in discussion and questions during the sessions to further their understanding of the topic and how it fits into modern day research and medicine. I believe in reverse teaching with the students becoming the lecturer as this helps to embed deeper learning and reaffirms knowledge. I believe “Learning should be fun not a chore!”

Supervisory Interests

PhD students

Previous PhD students 

Vishal Birar (2016)

The effects resveratrol and new novel analogues of this stilbene have on sirt1 activation

Badr Ibrahim (2010)

Mechanisms of replicative senescence in Werner's Syndrome cells.

Dominic Burton (2007)

Analysis of replicative senescence: a genomics approach

 

MRes projects

Previous MRes students 

Tegwen Elliott 2017-2018                                

Development of an in vitro model of gastric inflammation in pernicious anaemia and the effect of treatment with cobalamin.                                                               

Rasphal Flora 2014-2015

Investigating the pathogenicity of Klebsiella pneumoniae and its associated virulence factors in cases of clinical disease.

 

MSc projects

Previous MSc students 

Shannon Furness 2016-2017                                     

The Effect of Curcumin on Cellular Senescence, Viability, Proliferation, and Apoptosis in Breast Cancer Cells in Vitro.                                                                  

Duo Li. 2015-2016

Do senescent cells contribute to mucus secretion in COPD patience?

Aimee Hunt 2014-2015

The effects of adenosine, rotenone and resveratrol on senescence and mucin secretion within an immortalised rat tracheal epithelial cell line (SPOC1).

Jack Barker 2013-2014

Efficacy of the novel antiseptic coating, gendine, in the inhibition of Klebsiella pneumoniae growth and biofilm formation on urinary catheters.

Caroline Gill 2013-2014

he Role of Virulent Klebsiella pneumoniae in Pyogenic Liver Abscesses in Diabetic Patients.

Alexandra Appell 2012-2013

A novel treatment strategy for bacterial keratopathy.

Research interests

Current research projects

I am currently involved in looking into a number of themes, including ageing as a risk factor for COPD and CAA and the effects that senescent cells may contribute to these diseases.

  • Pathogenicity of Klebsiella pneumoniae and its associated virulence factors in cases of clinical disease and endotheliitis.
  • Effects of natural lignans and polyphenol compounds; such as curcumin, Quercetin, resveratrol on senescence and ageing.
  • Does senescence play a role in mucin secretion in patients with COPD.
  • Development of a novel cells line for testing drug delivery for new COPD treatments.

Previous research projects

  • Immortalisation and characterisation of canine gingival cells.
  • Is the lifespan in a long-lived mutant mouse strain limited by cell senescence.
  • Construction of a well differentiated cell line from human corneal endothelium.
  • Use of telomerase immortalisation to develop human islet b-cell lines safe for transplantation.

 

Knowledge exchange

Consultancy

Waltham centre for pet nutrition (MARS)

Education/Academic qualification

University of Sunderland

1 Sep 199731 Aug 2000

University of East London

20 Sep 19925 Jul 1996

Fingerprint Dive into the research topics where Angela Sheerin is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 2 Similar Profiles
Werner Syndrome Medicine & Life Sciences
Fibroblasts Medicine & Life Sciences
Cell Aging Medicine & Life Sciences
Telomerase Medicine & Life Sciences
Nuclear magnetic resonance Chemical Compounds
Transcription Factor AP-1 Medicine & Life Sciences
Pyruvic Acid Chemical Compounds
Progeria Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1997 2017

Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence

Latorre, E., Birar, V., Sheerin, A., Jeynes, C. C., Hooper, A., Dawe, H., Melzer, D., Cox, L., Faragher, R., Ostler, E. & Harries, L. W., 17 Oct 2017, In : BMC Cell Biology. 18

Research output: Contribution to journalArticle

Open Access
File
Cell Aging
Cell Cycle
Messenger RNA
Telomere
Fibroblasts

Absence of premature senescence in Werner's syndrome keratinocytes

Ibrahim, B., Sheerin, A., Jennert-Burston, K., Bird, J. L. E., Massala, M. V., Illsley, M., James, S. E. & Faragher, R., 2 Aug 2016, In : Experimental Gerontology. 83, p. 139-147 9 p.

Research output: Contribution to journalArticle

Open Access
File
Werner Syndrome
Keratinocytes
Fibroblasts
Cell Aging
Premature Aging

A facile, stereoselective, one-pot synthesis of resveratrol derivatives

Birar, V., Sheerin, A., Milkovicova, J., Faragher, R. & Ostler, E., 20 May 2015, In : Chemistry Central Journal. 9

Research output: Contribution to journalArticle

Open Access
File
Derivatives
Stilbenes
Electrons
Purification
Anti-Inflammatory Agents

Characterization of cellular senescence mechanisms in human corneal endothelial cells

Sheerin, A., Smith, S. K., Jennert-Burston, K., Brook, A. J., Allen, M., Ibrahim, B., Jones, D. L., Wallis, C., Engelmann, K., Rhys-Williams, W., Faragher, R. & Kipling, D., Apr 2012, In : Aging Cell. 11, 2, p. 234-240 7 p.

Research output: Contribution to journalArticle

Resveratrol, but not dihydroresveratrol, induces premature senescence in primary human fibroblasts

Faragher, R., Burton, D., Majecha, P., Fong, N. S., Davis, T., Sheerin, A. & Ostler, E., 12 Feb 2011, In : Age. 33, 4, p. 555-564 10 p.

Research output: Contribution to journalArticle