19972017

Research output per year

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Personal profile

Research interests

Her research is currently focusing on a few areas, they are varied but have a theme of ageing, cell biology cellular senescence and disease at their root. She is currently involved in looking at the impact cellular senescence may contribute to dementia and other age-related pathologies, such as CAA. She also has a been interest in ageing as a risk factor for COPD and CAA and the effects that senescent cells may contribute to these diseases and the effects novel senolytics have in clearing their senescent cells. In addition, she is involved with the recurrence of UTI infections in dementia patients and the impact this has to their cognitivity as well as developing an early detection system for use in the home or healthcare environment.

She works in collaboration with a number of colleagues in PABS to strengthen her knowledge and skills base as well as working with colleagues in other universities and is in the process of developing an NHS based partnership to bridge the gaps between bedside and research.

Outside of my research and teaching she is the founder and organiser of ‘A* scientist’. This is an outreach program that introduces 'hands on' science to primary schools in Sussex.

Current research projects

  • Modelling blood brain barrier (BBB) to investigate the impact senescence cells have in CAA and effects of recurrent UTIs on neuroplasticity environment and astrocyte functionality.

  • Development of a novel early detection system for UTI in the home or healthcare environment.  

  • Effects of natural lignans and polyphenol compounds; such as curcumin, Quercetin, resveratrol on senescence and ageing.

  • Does senescence play a role in mucin secretion in patients with COPD and CAA.

  • Pathogenicity of Klebsiella pneumoniae and its associated virulence factors in cases of clinical disease and endotheliitis.

  • Development of a novel cells line for testing drug delivery for new COPD treatments.

    Previous research projects

  • Immortalisation and characterisation of canine gingival cells.

  • Is the lifespan in a long-lived mutant mouse strain limited by cell senescence.

  • Construction of a well differentiated cell line from human corneal endothelium.

  • Use of telomerase immortalisation to develop human islet b-cell lines safe for transplantation.

Scholarly biography

Dr Angela Sheerin is a senior lecturer in the School of Pharmacy and Biomolecular Sciences. After joining the University of Brighton as a Research Fellow in 2000, I fostered a deep interest in ageing and senescence. This has since influenced my research in the fields of impact of senescence on ageing disorders, cerebral amyloid angiopathy (CAA), ophthalmology, micro-organisms and chronic obstructive pulmonary disease (COPD).

My first degree is in biochemistry (BSc (Hons) sandwich) from the University of East London. I did my PhD in molecular gerontology; Investigation of the composition of AP-1 during ageing. I came to the University of Brighton in 2000 as a research fellow and now lecture in the field of molecular biology, pathobiology, medical genetics, endocrinology and biochemistry.

Roles

  • Course leader MRES Biosciences
  • Module leader on the biosciences degree programmes.
  • Tissue culture manager
  • Biological safety officer (BSO)
  • Member of the safety committee
  • Chair of the genetically modified organism’s safety committee(GMSC)
  • Member of the editorial board for the rejuvenation research journal.
  • Founder of A* Science outreach programme for primary school children
  • Reviewer of grant applications for BBSRC, SPARC and Research Into Ageing.
  • Reviewer of papers for scientific journals.
  • STEM ambassador
  • Nuffield summer placement provider (2013-present)
  • Salters festival of chemistry judge (2012-present)

Approach to teaching

I am course leader for the MRES biosciences course and a senior lecturer of the biosciences teaching team for undergraduates studying biomedical science, biological science and ecology. I lecture in the area of molecular biology, cell biology, pathobiology, medical genetics, endocrinology, ageing and biochemistry. I am an enthusiastic lecturer who likes to use new and modern technologies to translate knowledge to the students.

I believe in 'hands on' practical experience as well as interactive learning through lectures, blended learning and flip learning. I use a lot of animation, videos and pod casts in my lectures to help give a wider choice of learning material. I expect my students to explore the topic area with the extended reading given in the sessions using both primary and secondary sources.

I want my students to engage in discussion and questions during the sessions to further their understanding of the topic and how it fits into modern day research and medicine. I believe in reverse teaching with the students becoming the lecturer as this helps to embed deeper learning and reaffirms knowledge. I believe “Learning should be fun not a chore!”

Supervisory Interests

PhD students

Previous PhD students 

Vishal Birar (2016)

The effects resveratrol and new novel analogues of this stilbene have on sirt1 activation

Badr Ibrahim (2010)

Mechanisms of replicative senescence in Werner's Syndrome cells.

Dominic Burton (2007)

Analysis of replicative senescence: a genomics approach

 

MRes projects

Previous MRes students 

Tegwen Elliott 2017-2018                                

Development of an in vitro model of gastric inflammation in pernicious anaemia and the effect of treatment with cobalamin.                                                               

Rasphal Flora 2014-2015

Investigating the pathogenicity of Klebsiella pneumoniae and its associated virulence factors in cases of clinical disease.

 

MSc projects

Previous MSc students 

Shannon Furness 2016-2017                                     

The Effect of Curcumin on Cellular Senescence, Viability, Proliferation, and Apoptosis in Breast Cancer Cells in Vitro.                                                                  

Duo Li. 2015-2016

Do senescent cells contribute to mucus secretion in COPD patience?

Aimee Hunt 2014-2015

The effects of adenosine, rotenone and resveratrol on senescence and mucin secretion within an immortalised rat tracheal epithelial cell line (SPOC1).

Jack Barker 2013-2014

Efficacy of the novel antiseptic coating, gendine, in the inhibition of Klebsiella pneumoniae growth and biofilm formation on urinary catheters.

Caroline Gill 2013-2014

he Role of Virulent Klebsiella pneumoniae in Pyogenic Liver Abscesses in Diabetic Patients.

Alexandra Appell 2012-2013

A novel treatment strategy for bacterial keratopathy.

Knowledge exchange

Consultancy

Waltham centre for pet nutrition (MARS)

Education/Academic qualification

University of Sunderland

1 Sep 199731 Aug 2000

University of East London

20 Sep 19925 Jul 1996

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Research Output

Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence

Latorre, E., Birar, V., Sheerin, A., Jeynes, C. C., Hooper, A., Dawe, H., Melzer, D., Cox, L., Faragher, R., Ostler, E. & Harries, L. W., 17 Oct 2017, In : BMC Cell Biology. 18

Research output: Contribution to journalArticle

Open Access
File
  • Absence of premature senescence in Werner's syndrome keratinocytes

    Ibrahim, B., Sheerin, A., Jennert-Burston, K., Bird, J. L. E., Massala, M. V., Illsley, M., James, S. E. & Faragher, R., 2 Aug 2016, In : Experimental Gerontology. 83, p. 139-147 9 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • A facile, stereoselective, one-pot synthesis of resveratrol derivatives

    Birar, V., Sheerin, A., Milkovicova, J., Faragher, R. & Ostler, E., 20 May 2015, In : Chemistry Central Journal. 9

    Research output: Contribution to journalArticle

    Open Access
    File
  • Characterization of cellular senescence mechanisms in human corneal endothelial cells

    Sheerin, A., Smith, S. K., Jennert-Burston, K., Brook, A. J., Allen, M., Ibrahim, B., Jones, D. L., Wallis, C., Engelmann, K., Rhys-Williams, W., Faragher, R. & Kipling, D., Apr 2012, In : Aging Cell. 11, 2, p. 234-240 7 p.

    Research output: Contribution to journalArticle

    Resveratrol, but not dihydroresveratrol, induces premature senescence in primary human fibroblasts

    Faragher, R., Burton, D., Majecha, P., Fong, N. S., Davis, T., Sheerin, A. & Ostler, E., 12 Feb 2011, In : Age. 33, 4, p. 555-564 10 p.

    Research output: Contribution to journalArticle