Transformation of a series of saturated 3α-substituted 17-keto and 17a-oxa-D-homo-steroids by aspergillus tamarii KITA reveals stereochemical restriction of steroid binding orientation in the minor hydroxylation pathway

A.C. Hunter; H. Khueni-Brady; P. Barrett; H.T. Dodd; Cynthia Dedi

doi:10.1016/j.jsbmb.2009.12.003

Transformation of a series of saturated 3α-substituted 17-keto and 17a-oxa-D-homo-steroids by aspergillus tamarii KITA reveals stereochemical restriction of steroid binding orientation in the minor hydroxylation pathway

A.C. Hunter, H. Khueni-Brady, P. Barrett, H.T. Dodd, Cynthia Dedi

University of Brighton

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	171-176
Number of pages	6
Journal	The Journal of Steroid Biochemistry and Molecular Biology
Volume	118
Issue number	3
DOIs	https://doi.org/10.1016/j.jsbmb.2009.12.003
Publication status	Published - 2010

Keywords

Aspergillus tamarii
3α-Steroid transformation
Hindered hydroxylase binding
Baeyer–Villiger oxidation
Enzyme induction
Biocatalyst

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10.1016/j.jsbmb.2009.12.003Licence: Unspecified

http://www.sciencedirect.com/science/article/pii/S0960076009002854Licence: Unspecified

Cite this

Hunter, A. C., Khueni-Brady, H., Barrett, P., Dodd, H. T., & Dedi, C. (2010). Transformation of a series of saturated 3α-substituted 17-keto and 17a-oxa-D-homo-steroids by aspergillus tamarii KITA reveals stereochemical restriction of steroid binding orientation in the minor hydroxylation pathway. The Journal of Steroid Biochemistry and Molecular Biology, 118(3), 171-176. https://doi.org/10.1016/j.jsbmb.2009.12.003

Hunter, A.C. ; Khueni-Brady, H. ; Barrett, P. et al. / Transformation of a series of saturated 3α-substituted 17-keto and 17a-oxa-D-homo-steroids by aspergillus tamarii KITA reveals stereochemical restriction of steroid binding orientation in the minor hydroxylation pathway. In: The Journal of Steroid Biochemistry and Molecular Biology. 2010 ; Vol. 118, No. 3. pp. 171-176.

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title = "Transformation of a series of saturated 3α-substituted 17-keto and 17a-oxa-D-homo-steroids by aspergillus tamarii KITA reveals stereochemical restriction of steroid binding orientation in the minor hydroxylation pathway",

keywords = "Aspergillus tamarii, 3α-Steroid transformation, Hindered hydroxylase binding, Baeyer–Villiger oxidation, Enzyme induction, Biocatalyst",

author = "A.C. Hunter and H. Khueni-Brady and P. Barrett and H.T. Dodd and Cynthia Dedi",

year = "2010",

doi = "10.1016/j.jsbmb.2009.12.003",

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Hunter, AC, Khueni-Brady, H, Barrett, P, Dodd, HT & Dedi, C 2010, 'Transformation of a series of saturated 3α-substituted 17-keto and 17a-oxa-D-homo-steroids by aspergillus tamarii KITA reveals stereochemical restriction of steroid binding orientation in the minor hydroxylation pathway', The Journal of Steroid Biochemistry and Molecular Biology, vol. 118, no. 3, pp. 171-176. https://doi.org/10.1016/j.jsbmb.2009.12.003

Transformation of a series of saturated 3α-substituted 17-keto and 17a-oxa-D-homo-steroids by aspergillus tamarii KITA reveals stereochemical restriction of steroid binding orientation in the minor hydroxylation pathway. / Hunter, A.C.; Khueni-Brady, H.; Barrett, P. et al.
In: The Journal of Steroid Biochemistry and Molecular Biology, Vol. 118, No. 3, 2010, p. 171-176.

Research output: Contribution to journal › Article › peer-review

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AU - Hunter, A.C.

AU - Khueni-Brady, H.

AU - Barrett, P.

AU - Dodd, H.T.

AU - Dedi, Cynthia

PY - 2010

Y1 - 2010

KW - Aspergillus tamarii

KW - 3α-Steroid transformation

KW - Hindered hydroxylase binding

KW - Baeyer–Villiger oxidation

KW - Enzyme induction

KW - Biocatalyst

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DO - 10.1016/j.jsbmb.2009.12.003

M3 - Article

SN - 0960-0760

VL - 118

SP - 171

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JO - The Journal of Steroid Biochemistry and Molecular Biology

JF - The Journal of Steroid Biochemistry and Molecular Biology

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Hunter AC, Khueni-Brady H, Barrett P, Dodd HT, Dedi C. Transformation of a series of saturated 3α-substituted 17-keto and 17a-oxa-D-homo-steroids by aspergillus tamarii KITA reveals stereochemical restriction of steroid binding orientation in the minor hydroxylation pathway. The Journal of Steroid Biochemistry and Molecular Biology. 2010;118(3):171-176. doi: 10.1016/j.jsbmb.2009.12.003