Towards new nanoporous biomaterials: self-assembly of sulfopillar[5]arenes with vitamin D3 into supramolecular polymers

Dmitriy Shurpik, Yulia Aleksandrova, Pavel Zelenikhin, Evgenia Subakaeva, Peter Cragg, Ivan Stoikov

Research output: Contribution to journalArticle

Abstract

Novel water-soluble, deca-substituted pillar[5]arenes containing thiasulfate and thiacarboxylate fragments were synthesized and characterized. UV-vis, 2D 1H- 1H NOESY and DOSY NMR spectroscopy revealed the ability of pillar[5]arenes containing thiasulfate fragments to form an inclusion complex with cholecalciferol (vitamin D 3) in a 1 : 2 ratio (lg K ass= 2.2). Using DLS and SEM it was found that upon concentration and/or evaporation of the solvent, the supramolecular polymer (pillar[5]arene/vitamin D 3(1 : 2)) forms a porous material with an average wall diameter of 53 nm. It was shown that the supramolecular polymer is stable during photolysis by UV radiation (k 1= 1.7 × 10 −5s −1).

Original languageEnglish
Pages (from-to)4210-4216
Number of pages7
JournalOrganic & Biomolecular Chemistry
Volume18
Issue number22
DOIs
Publication statusPublished - 31 Mar 2020

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