The immunological synapse

R.J. Creusot, N.A. Mitchison, Nadia Terrazzini

Research output: Contribution to journalArticlepeer-review


The immunological synapse plays a central role in organising the immune system. Through their synaptic activity both T and B cells usually, but not always, acquire the information that critically determines the level and nature of the responses that they make. For T cells much of that information comes from epicrine and paracrine cell-cell interactions in the cluster that forms around a dendritic cell. These interactions are being dissected by experiments in which two populations of TCR-transgenic T cells are combined in vivo. Another important aspect of synaptic activity is the way in which different levels of expression of MHC class II molecules influence Th1/Th2 balance. In exploring this form of control we are learning something of general importance about cis-regulation.
Original languageEnglish
Pages (from-to)997-1002
Number of pages6
JournalMolecular Immunology
Issue number12-13
Publication statusPublished - 1 May 2002


  • Synaptic activity
  • T cells
  • Dendritic cell


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