The basics and underlying mechanisms of mucoadhesion

Research output: Contribution to journalArticle

Abstract

Mucoadhesion is where two surfaces, one of which is a mucous membrane, adhere to each other. This has been of interest in the pharmaceutical sciences in order to enhance localised drug delivery, or to deliver ‘difficult’ molecules (proteins and oligonucleotides) into the systemic circulation. Mucoadhesive materials are hydrophilic macromolecules containing numerous hydrogen bond forming groups, the carbomers and chitosans being two well-known examples. The mechanism by which mucoadhesion takes place has been said to have two stages, the contact (wetting) stage followed by the consolidation stage (the establishment of the adhesive interactions). The relative importance of each stage will depend on the individual application. For example, adsorption is a key stage if the dosage form cannot be applied directly to the mucosa of interest, while consolidation is important if the formulation is exposed to significant dislodging stresses. Adhesive joint failure will inevitably occur as a result of overhydration of a dosage form, or as a result of epithelia or mucus turnover. New mucoadhesive materials with optimal adhesive properties are now being developed, and these should enhance the potential applications of this technology.
Original languageEnglish
Pages (from-to)1556-1568
Number of pages13
JournalAdvanced Drug Delivery Reviews
Volume57
Issue number11
DOIs
Publication statusPublished - Nov 2005

Fingerprint

Dosage Forms
Consolidation
Adhesives
Adhesive joints
Chitosan
Macromolecules
Drug delivery
Oligonucleotides
Wetting
Hydrogen bonds
Adsorption
Molecules
Pharmaceutical Preparations
Proteins
Mucous Membrane
carbomer

Keywords

  • Mucoadhesion
  • Mucoadhesives
  • Bioadhesion
  • Bioadhesives
  • Mucosal delivery
  • Carbomers

Cite this

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The basics and underlying mechanisms of mucoadhesion. / Smart, John.

In: Advanced Drug Delivery Reviews, Vol. 57, No. 11, 11.2005, p. 1556-1568.

Research output: Contribution to journalArticle

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