Structurally plastic peptide capsules for synthetic antimicrobial viruses

Valeria Castelletto, Emiliana De Santis, Hasan Alkassem, Baptiste Lamarre, James E. Noble, Santanu Ray, Angelo Bella, Jonathan R. Burns, Bart W. Hoogenboom, Maxim G. Ryadnov

Research output: Contribution to journalArticle

Abstract

A conceptual design for artificial antimicrobial viruses is described. The design emulates viral assembly and function to create self-assembling peptide capsules that promote efficient gene delivery and silencing in mammalian cells. Unlike viruses, however, the capsules are antimicrobial, which allows them to exhibit a dual biological function: gene transport and antimicrobial activity. Unlike other antimicrobials, the capsules act as pre-concentrated antimicrobial agents that elicit rapid and localised membrane-disrupting responses by converting into individual pores at their precise landing positions on membranes. The concept holds promise for engineering virus-like scaffolds with biologically tuneable properties.

Original languageEnglish
Pages (from-to)1707-1711
Number of pages5
JournalChemical Science
Volume7
Issue number3
DOIs
Publication statusPublished - 21 Dec 2015

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Viruses
Capsules
Plastics
Peptides
Genes
Membranes
Anti-Infective Agents
Conceptual design
Landing
Scaffolds
Cells

Cite this

Castelletto, V., De Santis, E., Alkassem, H., Lamarre, B., Noble, J. E., Ray, S., ... Ryadnov, M. G. (2015). Structurally plastic peptide capsules for synthetic antimicrobial viruses. Chemical Science, 7(3), 1707-1711. https://doi.org/10.1039/c5sc03260a
Castelletto, Valeria ; De Santis, Emiliana ; Alkassem, Hasan ; Lamarre, Baptiste ; Noble, James E. ; Ray, Santanu ; Bella, Angelo ; Burns, Jonathan R. ; Hoogenboom, Bart W. ; Ryadnov, Maxim G. / Structurally plastic peptide capsules for synthetic antimicrobial viruses. In: Chemical Science. 2015 ; Vol. 7, No. 3. pp. 1707-1711.
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Castelletto, V, De Santis, E, Alkassem, H, Lamarre, B, Noble, JE, Ray, S, Bella, A, Burns, JR, Hoogenboom, BW & Ryadnov, MG 2015, 'Structurally plastic peptide capsules for synthetic antimicrobial viruses', Chemical Science, vol. 7, no. 3, pp. 1707-1711. https://doi.org/10.1039/c5sc03260a

Structurally plastic peptide capsules for synthetic antimicrobial viruses. / Castelletto, Valeria; De Santis, Emiliana; Alkassem, Hasan; Lamarre, Baptiste; Noble, James E.; Ray, Santanu; Bella, Angelo; Burns, Jonathan R.; Hoogenboom, Bart W.; Ryadnov, Maxim G.

In: Chemical Science, Vol. 7, No. 3, 21.12.2015, p. 1707-1711.

Research output: Contribution to journalArticle

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AU - Bella, Angelo

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Castelletto V, De Santis E, Alkassem H, Lamarre B, Noble JE, Ray S et al. Structurally plastic peptide capsules for synthetic antimicrobial viruses. Chemical Science. 2015 Dec 21;7(3):1707-1711. https://doi.org/10.1039/c5sc03260a