Strain differences in the anxiolytic effects of losartan in the mouse

Paul Gard, S.J. Haigh, P.T. Cambursano, C.A. Warrington

Research output: Contribution to journalArticle

Abstract

Anxiolytic effects of the angiotensin AT1 receptor antagonist losartan were studied in the elevated plus maze (EPM) and the light/dark test (LDT) in different mouse strains as were responses to angiotensin II and acetylcholine in isolated ascending colon. There were no significant strain differences in behaviour on the EPM, and diazepam was anxiolytic in C57BL/6, DBA/2 and BKW mice. Losartan was anxiolytic in BKW only. In the LDT, there were significant strain differences, with BKW mice exhibiting greatest anxiety-like behaviour; losartan was ineffective in this test. In vitro responses to angiotensin II and acetylcholine were significantly smaller in BKW than in C57BL/6 and DBA/2. These results indicate that the mouse strain exhibiting least angiotensin receptor function is the most responsive to the anxiolytic effects, suggesting a possible relationship between angiotensin receptor function and anxiolytic response to losartan.
Original languageEnglish
Pages (from-to)35-40
Number of pages6
JournalPharmacology Biochemistry and Behavior
Volume69
Issue number1-2
DOIs
Publication statusPublished - May 2001

Keywords

  • Losartan
  • Strain
  • Anxiolytic
  • Elevated plus maze
  • Light/dark test

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