Risk factors and future directions for preventing and diagnosing exertional rhabdomyolysis

Andréia  Carneiro; Diego  Viana-Gomes; Janaina  Macedo-da-Silva; Giscard Humberto Oliveira  Lima; Simone  Mitri; Sergio Rabello  Alves; Alexander Kolliari-Turner; Edmar  Zanoteli; Francisco Radler de Aquino  Neto; Giuseppe  Palmisano; João Bosco  Pesquero; Josino Costa  Moreira; Marcos Dias  Pereira

doi:10.1016/j.nmd.2021.04.007

Risk factors and future directions for preventing and diagnosing exertional rhabdomyolysis

Andréia Carneiro, Diego Viana-Gomes, Janaina Macedo-da-Silva, Giscard Humberto Oliveira Lima, Simone Mitri, Sergio Rabello Alves, Alexander Kolliari-Turner, Edmar Zanoteli, Francisco Radler de Aquino Neto, Giuseppe Palmisano, João Bosco Pesquero, Josino Costa Moreira, Marcos Dias Pereira

Doctoral College

Research output: Contribution to journal › Article › peer-review

Abstract

Exertional rhabdomyolysis may occur when an individual is subjected to strenuous physical exercise. It is occasionally associated with myoglobinuria (i.e. “cola-colored” urine) alongside muscle pain and weakness. The pathophysiology of exertional rhabdomyolysis involves striated muscle damage and the release of cellular components into extracellular fluid and bloodstream. This can cause acute renal failure, electrolyte abnormalities, arrhythmias and potentially death. Exertional rhabdomyolysis is observed in high-performance athletes who are subjected to intense, repetitive and/or prolonged exercise but is also observed in untrained individuals and highly trained or elite groups of military personnel. Several risk factors have been reported to increase the likelihood of the condition in athletes, including: viral infection, drug and alcohol abuse, exercise in intensely hot and humid environments, genetic polymorphisms (e.g. sickle cell trait and McArdle disease) and epigenetic modifications. This article reviews several of these risk factors and proposes screening protocols to identify individual susceptibility to exertional rhabdomyolysis as well as the relevance of proteomics for the evaluation of potential biomarkers of muscle damage.

Original language	English
Pages (from-to)	583-595
Number of pages	13
Journal	Neuromuscular Disorders
Volume	31
Issue number	7
DOIs	https://doi.org/10.1016/j.nmd.2021.04.007
Publication status	Published - 5 May 2021

Bibliographical note

Funding Information: The authors would like to thank the Comando do Material do Corpo de Fuzileiros Navais, Marinha do Brasil, Centro de Instru??o Almirante Sylvio de Camargo, Marinha do Brasil; Centro de Tecnologia do Corpo dos Fuzileiros Navais, Marinha do Brasil. We also thank the Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES), Conselho Nacional de Pesquisas e Desenvolvimento Tecnol?gico (CNPq), Funda??o Carlos Chagas de Amparo ? Pesquisa do Rio de Janeiro (FAPERJ) and Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo (FAPESP - 2018/18257-1, 2018/15549-1, 2020/04923-0 and 2014/27298-8) who provided financial support for this study. Funding Information: The authors would like to thank the Comando do Material do Corpo de Fuzileiros Navais, Marinha do Brasil, Centro de Instrução Almirante Sylvio de Camargo, Marinha do Brasil; Centro de Tecnologia do Corpo dos Fuzileiros Navais, Marinha do Brasil. We also thank the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Conselho Nacional de Pesquisas e Desenvolvimento Tecnológico (CNPq), Fundação Carlos Chagas de Amparo à Pesquisa do Rio de Janeiro (FAPERJ) and Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP - 2018/18257-1, 2018/15549-1, 2020/04923-0 and 2014/27298-8) who provided financial support for this study.

Keywords

Acute renal failure
Epigenetics
Exertional rhabdomyolysis
Genetic polymorphisms
Military personnel
Proteomics
Risk factors

Access to Document

10.1016/j.nmd.2021.04.007

Cite this

Carneiro, A., Viana-Gomes, D., Macedo-da-Silva, J., Lima, G. H. O., Mitri, S., Alves, S. R., Kolliari-Turner, A., Zanoteli, E., Neto, F. R. D. A., Palmisano, G., Pesquero, J. B., Moreira, J. C., & Pereira, M. D. (2021). Risk factors and future directions for preventing and diagnosing exertional rhabdomyolysis. Neuromuscular Disorders, 31(7), 583-595. https://doi.org/10.1016/j.nmd.2021.04.007

@article{ce6b551ef04b41eaba8a1975e68b73c9,

title = "Risk factors and future directions for preventing and diagnosing exertional rhabdomyolysis",

abstract = "Exertional rhabdomyolysis may occur when an individual is subjected to strenuous physical exercise. It is occasionally associated with myoglobinuria (i.e. “cola-colored” urine) alongside muscle pain and weakness. The pathophysiology of exertional rhabdomyolysis involves striated muscle damage and the release of cellular components into extracellular fluid and bloodstream. This can cause acute renal failure, electrolyte abnormalities, arrhythmias and potentially death. Exertional rhabdomyolysis is observed in high-performance athletes who are subjected to intense, repetitive and/or prolonged exercise but is also observed in untrained individuals and highly trained or elite groups of military personnel. Several risk factors have been reported to increase the likelihood of the condition in athletes, including: viral infection, drug and alcohol abuse, exercise in intensely hot and humid environments, genetic polymorphisms (e.g. sickle cell trait and McArdle disease) and epigenetic modifications. This article reviews several of these risk factors and proposes screening protocols to identify individual susceptibility to exertional rhabdomyolysis as well as the relevance of proteomics for the evaluation of potential biomarkers of muscle damage.",

keywords = "Acute renal failure, Epigenetics, Exertional rhabdomyolysis, Genetic polymorphisms, Military personnel, Proteomics, Risk factors",

author = "Andr{\'e}ia Carneiro and Diego Viana-Gomes and Janaina Macedo-da-Silva and Lima, {Giscard Humberto Oliveira} and Simone Mitri and Alves, {Sergio Rabello} and Alexander Kolliari-Turner and Edmar Zanoteli and Neto, {Francisco Radler de Aquino} and Giuseppe Palmisano and Pesquero, {Jo{\~a}o Bosco} and Moreira, {Josino Costa} and Pereira, {Marcos Dias}",

note = "Funding Information: The authors would like to thank the Comando do Material do Corpo de Fuzileiros Navais, Marinha do Brasil, Centro de Instru??o Almirante Sylvio de Camargo, Marinha do Brasil; Centro de Tecnologia do Corpo dos Fuzileiros Navais, Marinha do Brasil. We also thank the Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES), Conselho Nacional de Pesquisas e Desenvolvimento Tecnol?gico (CNPq), Funda??o Carlos Chagas de Amparo ? Pesquisa do Rio de Janeiro (FAPERJ) and Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo (FAPESP - 2018/18257-1, 2018/15549-1, 2020/04923-0 and 2014/27298-8) who provided financial support for this study. Funding Information: The authors would like to thank the Comando do Material do Corpo de Fuzileiros Navais, Marinha do Brasil, Centro de Instru{\c c}{\~a}o Almirante Sylvio de Camargo, Marinha do Brasil; Centro de Tecnologia do Corpo dos Fuzileiros Navais, Marinha do Brasil. We also thank the Coordena{\c c}{\~a}o de Aperfei{\c c}oamento de Pessoal de N{\'i}vel Superior (CAPES), Conselho Nacional de Pesquisas e Desenvolvimento Tecnol{\'o}gico (CNPq), Funda{\c c}{\~a}o Carlos Chagas de Amparo {\`a} Pesquisa do Rio de Janeiro (FAPERJ) and Funda{\c c}{\~a}o de Amparo {\`a} Pesquisa do Estado de S{\~a}o Paulo (FAPESP - 2018/18257-1, 2018/15549-1, 2020/04923-0 and 2014/27298-8) who provided financial support for this study.",

year = "2021",

month = may,

day = "5",

doi = "10.1016/j.nmd.2021.04.007",

language = "English",

volume = "31",

pages = "583--595",

journal = "Neuromuscular Disorders",

issn = "0960-8966",

number = "7",

}

Carneiro, A, Viana-Gomes, D, Macedo-da-Silva, J, Lima, GHO, Mitri, S, Alves, SR, Kolliari-Turner, A, Zanoteli, E, Neto, FRDA, Palmisano, G, Pesquero, JB, Moreira, JC & Pereira, MD 2021, 'Risk factors and future directions for preventing and diagnosing exertional rhabdomyolysis', Neuromuscular Disorders, vol. 31, no. 7, pp. 583-595. https://doi.org/10.1016/j.nmd.2021.04.007

TY - JOUR

T1 - Risk factors and future directions for preventing and diagnosing exertional rhabdomyolysis

AU - Carneiro, Andréia

AU - Viana-Gomes, Diego

AU - Macedo-da-Silva, Janaina

AU - Lima, Giscard Humberto Oliveira

AU - Mitri, Simone

AU - Alves, Sergio Rabello

AU - Kolliari-Turner, Alexander

AU - Zanoteli, Edmar

AU - Neto, Francisco Radler de Aquino

AU - Palmisano, Giuseppe

AU - Pesquero, João Bosco

AU - Moreira, Josino Costa

AU - Pereira, Marcos Dias

N1 - Funding Information: The authors would like to thank the Comando do Material do Corpo de Fuzileiros Navais, Marinha do Brasil, Centro de Instru??o Almirante Sylvio de Camargo, Marinha do Brasil; Centro de Tecnologia do Corpo dos Fuzileiros Navais, Marinha do Brasil. We also thank the Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES), Conselho Nacional de Pesquisas e Desenvolvimento Tecnol?gico (CNPq), Funda??o Carlos Chagas de Amparo ? Pesquisa do Rio de Janeiro (FAPERJ) and Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo (FAPESP - 2018/18257-1, 2018/15549-1, 2020/04923-0 and 2014/27298-8) who provided financial support for this study. Funding Information: The authors would like to thank the Comando do Material do Corpo de Fuzileiros Navais, Marinha do Brasil, Centro de Instrução Almirante Sylvio de Camargo, Marinha do Brasil; Centro de Tecnologia do Corpo dos Fuzileiros Navais, Marinha do Brasil. We also thank the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Conselho Nacional de Pesquisas e Desenvolvimento Tecnológico (CNPq), Fundação Carlos Chagas de Amparo à Pesquisa do Rio de Janeiro (FAPERJ) and Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP - 2018/18257-1, 2018/15549-1, 2020/04923-0 and 2014/27298-8) who provided financial support for this study.

PY - 2021/5/5

Y1 - 2021/5/5

N2 - Exertional rhabdomyolysis may occur when an individual is subjected to strenuous physical exercise. It is occasionally associated with myoglobinuria (i.e. “cola-colored” urine) alongside muscle pain and weakness. The pathophysiology of exertional rhabdomyolysis involves striated muscle damage and the release of cellular components into extracellular fluid and bloodstream. This can cause acute renal failure, electrolyte abnormalities, arrhythmias and potentially death. Exertional rhabdomyolysis is observed in high-performance athletes who are subjected to intense, repetitive and/or prolonged exercise but is also observed in untrained individuals and highly trained or elite groups of military personnel. Several risk factors have been reported to increase the likelihood of the condition in athletes, including: viral infection, drug and alcohol abuse, exercise in intensely hot and humid environments, genetic polymorphisms (e.g. sickle cell trait and McArdle disease) and epigenetic modifications. This article reviews several of these risk factors and proposes screening protocols to identify individual susceptibility to exertional rhabdomyolysis as well as the relevance of proteomics for the evaluation of potential biomarkers of muscle damage.

AB - Exertional rhabdomyolysis may occur when an individual is subjected to strenuous physical exercise. It is occasionally associated with myoglobinuria (i.e. “cola-colored” urine) alongside muscle pain and weakness. The pathophysiology of exertional rhabdomyolysis involves striated muscle damage and the release of cellular components into extracellular fluid and bloodstream. This can cause acute renal failure, electrolyte abnormalities, arrhythmias and potentially death. Exertional rhabdomyolysis is observed in high-performance athletes who are subjected to intense, repetitive and/or prolonged exercise but is also observed in untrained individuals and highly trained or elite groups of military personnel. Several risk factors have been reported to increase the likelihood of the condition in athletes, including: viral infection, drug and alcohol abuse, exercise in intensely hot and humid environments, genetic polymorphisms (e.g. sickle cell trait and McArdle disease) and epigenetic modifications. This article reviews several of these risk factors and proposes screening protocols to identify individual susceptibility to exertional rhabdomyolysis as well as the relevance of proteomics for the evaluation of potential biomarkers of muscle damage.

KW - Acute renal failure

KW - Epigenetics

KW - Exertional rhabdomyolysis

KW - Genetic polymorphisms

KW - Military personnel

KW - Proteomics

KW - Risk factors

UR - http://www.scopus.com/inward/record.url?scp=85108957754&partnerID=8YFLogxK

U2 - 10.1016/j.nmd.2021.04.007

DO - 10.1016/j.nmd.2021.04.007

M3 - Article

SN - 0960-8966

VL - 31

SP - 583

EP - 595

JO - Neuromuscular Disorders

JF - Neuromuscular Disorders

IS - 7

ER -

Risk factors and future directions for preventing and diagnosing exertional rhabdomyolysis

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this