New model for the interaction of IQGAP1 with CDC42 and RAC1

Kazem Nouri, David Timson, Mohammad R. Ahmadian

Research output: Contribution to journalArticle

Abstract

The specific and rapid formation of protein complexes, involving IQGAP family proteins,is essential for diverse cellular processes, such as adhesion, polarization, and directional migration. Although CDC42 and RAC1, prominent members of the RHO GTPase family, have been implicated in binding to and activating IQGAP1, the exact nature of this protein-protein recognition process has remained obscure. Here, we propose a mechanistic framework model that is based on a multiple-step binding process, which is a prerequisite for the dynamic functions of IQGAP1 as a scaffolding protein and a critical mechanism in temporal regulation andintegration of cellular pathways.
Original languageEnglish
JournalSmall GTPases
DOIs
Publication statusPublished - 19 Jun 2017

Fingerprint

Proteins
GTP Phosphohydrolases
Adhesion
Polarization

Bibliographical note

This is an Accepted Manuscript of an article published by Taylor & Francis in Small GTPases on 16/06/2017, available online: http://www.tandfonline.com/10.1080/21541248.2017.1321169

Keywords

  • CDC42
  • IQGAP1
  • RAC1
  • RHO effectors
  • RHO GTPases

Cite this

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abstract = "The specific and rapid formation of protein complexes, involving IQGAP family proteins,is essential for diverse cellular processes, such as adhesion, polarization, and directional migration. Although CDC42 and RAC1, prominent members of the RHO GTPase family, have been implicated in binding to and activating IQGAP1, the exact nature of this protein-protein recognition process has remained obscure. Here, we propose a mechanistic framework model that is based on a multiple-step binding process, which is a prerequisite for the dynamic functions of IQGAP1 as a scaffolding protein and a critical mechanism in temporal regulation andintegration of cellular pathways.",
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New model for the interaction of IQGAP1 with CDC42 and RAC1. / Nouri, Kazem; Timson, David; Ahmadian, Mohammad R.

In: Small GTPases, 19.06.2017.

Research output: Contribution to journalArticle

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T1 - New model for the interaction of IQGAP1 with CDC42 and RAC1

AU - Nouri, Kazem

AU - Timson, David

AU - Ahmadian, Mohammad R.

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PY - 2017/6/19

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AB - The specific and rapid formation of protein complexes, involving IQGAP family proteins,is essential for diverse cellular processes, such as adhesion, polarization, and directional migration. Although CDC42 and RAC1, prominent members of the RHO GTPase family, have been implicated in binding to and activating IQGAP1, the exact nature of this protein-protein recognition process has remained obscure. Here, we propose a mechanistic framework model that is based on a multiple-step binding process, which is a prerequisite for the dynamic functions of IQGAP1 as a scaffolding protein and a critical mechanism in temporal regulation andintegration of cellular pathways.

KW - CDC42

KW - IQGAP1

KW - RAC1

KW - RHO effectors

KW - RHO GTPases

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