New model for the interaction of IQGAP1 with CDC42 and RAC1

Kazem Nouri; David Timson; Mohammad R. Ahmadian

doi:10.1080/21541248.2017.1321169

New model for the interaction of IQGAP1 with CDC42 and RAC1

Kazem Nouri, David Timson, Mohammad R. Ahmadian

Research output: Contribution to journal › Article › peer-review

Abstract

The specific and rapid formation of protein complexes, involving IQGAP family proteins,is essential for diverse cellular processes, such as adhesion, polarization, and directional migration. Although CDC42 and RAC1, prominent members of the RHO GTPase family, have been implicated in binding to and activating IQGAP1, the exact nature of this protein-protein recognition process has remained obscure. Here, we propose a mechanistic framework model that is based on a multiple-step binding process, which is a prerequisite for the dynamic functions of IQGAP1 as a scaffolding protein and a critical mechanism in temporal regulation andintegration of cellular pathways.

Original language	English
Journal	Small GTPases
DOIs	https://doi.org/10.1080/21541248.2017.1321169
Publication status	Published - 19 Jun 2017

Bibliographical note

This is an Accepted Manuscript of an article published by Taylor & Francis in Small GTPases on 16/06/2017, available online: http://www.tandfonline.com/10.1080/21541248.2017.1321169

Keywords

CDC42
IQGAP1
RAC1
RHO effectors
RHO GTPases

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abstract = "The specific and rapid formation of protein complexes, involving IQGAP family proteins,is essential for diverse cellular processes, such as adhesion, polarization, and directional migration. Although CDC42 and RAC1, prominent members of the RHO GTPase family, have been implicated in binding to and activating IQGAP1, the exact nature of this protein-protein recognition process has remained obscure. Here, we propose a mechanistic framework model that is based on a multiple-step binding process, which is a prerequisite for the dynamic functions of IQGAP1 as a scaffolding protein and a critical mechanism in temporal regulation andintegration of cellular pathways.",

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AU - Timson, David

AU - Ahmadian, Mohammad R.

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KW - CDC42

KW - IQGAP1

KW - RAC1

KW - RHO effectors

KW - RHO GTPases

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M3 - Article

SN - 2154-1248

JO - Small GTPases

JF - Small GTPases

ER -

New model for the interaction of IQGAP1 with CDC42 and RAC1

Abstract

Bibliographical note

Keywords

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