Mammalian triokinase and dihydroxyacetone kinase are the same enzyme

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Abstract

It is widely accepted that the ATP-dependent phosphorylation of D-glyceraldehyde in the fructokinase pathway of fructose metabolism requires the enzyme "triokinase". However, experimental data on this enzyme are remarkably scarce. The enzyme has been purified from a variety of sources and peptides derived from the pig kidney enzyme show high similarity to human dihydroxyacetone kinase - an enzyme which also has FMN cyclase activity in high manganese ion concentrations. The properties of the two enzymes are also highly similar. Therefore it is proposed that mammalian triokinase and dihydroxyacetone kinase are, in fact, the same enzyme. This has consequences for investigations of normal and aberrant fructose metabolism and for the teaching of biochemistry in medical and science courses.

Original languageEnglish
Title of host publicationFructose
Subtitle of host publicationSynthesis, Functions and Health Implications
PublisherNova Science Publishers Inc
Pages153-160
Number of pages8
ISBN (Print)9781620811269
Publication statusPublished - 1 Mar 2012

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