LIAD-fs scheme for studies of ultrafast laser interactions with gas phase biomolecules

C. R. Calvert; L. Belshaw; M. J. Duffy; O. Kelly; R. B. King; A. G. Smyth; T. J. Kelly; J. T. Costello; D. J. Timson; W. A. Bryan; T. Kierspel; P. Rice; I. C.E. Turcu; C. M. Cacho; E. Springate; I. D. Williams; J. B. Greenwood

doi:10.1039/c2cp23840c

LIAD-fs scheme for studies of ultrafast laser interactions with gas phase biomolecules

C. R. Calvert, L. Belshaw, M. J. Duffy, O. Kelly, R. B. King, A. G. Smyth, T. J. Kelly, J. T. Costello, D. J. Timson, W. A. Bryan, T. Kierspel, P. Rice, I. C.E. Turcu, C. M. Cacho, E. Springate, I. D. Williams, J. B. Greenwood

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Abstract

Laser induced acoustic desorption (LIAD) has been used for the first time to study the parent ion production and fragmentation mechanisms of a biological molecule in an intense femtosecond (fs) laser field. The photoacoustic shock wave generated in the analyte substrate (thin Ta foil) has been simulated using the hydrodynamic HYADES code, and the full LIAD process has been experimentally characterised as a function of the desorption UV-laser pulse parameters. Observed neutral plumes of densities >10 ⁹ cm ^-3 which are free from solvent or matrix contamination demonstrate the suitability and potential of the source for studying ultrafast dynamics in the gas phase using fs laser pulses. Results obtained with phenylalanine show that through manipulation of fundamental femtosecond laser parameters (such as pulse length, intensity and wavelength), energy deposition within the molecule can be controlled to allow enhancement of parent ion production or generation of characteristic fragmentation patterns. In particular by reducing the pulse length to a timescale equivalent to the fastest vibrational periods in the molecule, we demonstrate how fragmentation of the molecule can be minimised whilst maintaining a high ionisation efficiency.

Original language	English
Pages (from-to)	6289-6297
Number of pages	9
Journal	Physical Chemistry Chemical Physics
Volume	14
Issue number	18
DOIs	https://doi.org/10.1039/c2cp23840c
Publication status	Published - 14 May 2012

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Calvert, C. R., Belshaw, L., Duffy, M. J., Kelly, O., King, R. B., Smyth, A. G., Kelly, T. J., Costello, J. T., Timson, D. J., Bryan, W. A., Kierspel, T., Rice, P., Turcu, I. C. E., Cacho, C. M., Springate, E., Williams, I. D., & Greenwood, J. B. (2012). LIAD-fs scheme for studies of ultrafast laser interactions with gas phase biomolecules. Physical Chemistry Chemical Physics, 14(18), 6289-6297. https://doi.org/10.1039/c2cp23840c

@article{c2977e5480dd451ab51947dd195466cd,

title = "LIAD-fs scheme for studies of ultrafast laser interactions with gas phase biomolecules",

abstract = "Laser induced acoustic desorption (LIAD) has been used for the first time to study the parent ion production and fragmentation mechanisms of a biological molecule in an intense femtosecond (fs) laser field. The photoacoustic shock wave generated in the analyte substrate (thin Ta foil) has been simulated using the hydrodynamic HYADES code, and the full LIAD process has been experimentally characterised as a function of the desorption UV-laser pulse parameters. Observed neutral plumes of densities >10 9 cm -3 which are free from solvent or matrix contamination demonstrate the suitability and potential of the source for studying ultrafast dynamics in the gas phase using fs laser pulses. Results obtained with phenylalanine show that through manipulation of fundamental femtosecond laser parameters (such as pulse length, intensity and wavelength), energy deposition within the molecule can be controlled to allow enhancement of parent ion production or generation of characteristic fragmentation patterns. In particular by reducing the pulse length to a timescale equivalent to the fastest vibrational periods in the molecule, we demonstrate how fragmentation of the molecule can be minimised whilst maintaining a high ionisation efficiency.",

author = "Calvert, {C. R.} and L. Belshaw and Duffy, {M. J.} and O. Kelly and King, {R. B.} and Smyth, {A. G.} and Kelly, {T. J.} and Costello, {J. T.} and Timson, {D. J.} and Bryan, {W. A.} and T. Kierspel and P. Rice and Turcu, {I. C.E.} and Cacho, {C. M.} and E. Springate and Williams, {I. D.} and Greenwood, {J. B.}",

year = "2012",

month = may,

day = "14",

doi = "10.1039/c2cp23840c",

language = "English",

volume = "14",

pages = "6289--6297",

journal = "Physical Chemistry Chemical Physics",

issn = "1463-9076",

number = "18",

}

Calvert, CR, Belshaw, L, Duffy, MJ, Kelly, O, King, RB, Smyth, AG, Kelly, TJ, Costello, JT, Timson, DJ, Bryan, WA, Kierspel, T, Rice, P, Turcu, ICE, Cacho, CM, Springate, E, Williams, ID & Greenwood, JB 2012, 'LIAD-fs scheme for studies of ultrafast laser interactions with gas phase biomolecules', Physical Chemistry Chemical Physics, vol. 14, no. 18, pp. 6289-6297. https://doi.org/10.1039/c2cp23840c

TY - JOUR

T1 - LIAD-fs scheme for studies of ultrafast laser interactions with gas phase biomolecules

AU - Calvert, C. R.

AU - Belshaw, L.

AU - Duffy, M. J.

AU - Kelly, O.

AU - King, R. B.

AU - Smyth, A. G.

AU - Kelly, T. J.

AU - Costello, J. T.

AU - Timson, D. J.

AU - Bryan, W. A.

AU - Kierspel, T.

AU - Rice, P.

AU - Turcu, I. C.E.

AU - Cacho, C. M.

AU - Springate, E.

AU - Williams, I. D.

AU - Greenwood, J. B.

PY - 2012/5/14

Y1 - 2012/5/14

N2 - Laser induced acoustic desorption (LIAD) has been used for the first time to study the parent ion production and fragmentation mechanisms of a biological molecule in an intense femtosecond (fs) laser field. The photoacoustic shock wave generated in the analyte substrate (thin Ta foil) has been simulated using the hydrodynamic HYADES code, and the full LIAD process has been experimentally characterised as a function of the desorption UV-laser pulse parameters. Observed neutral plumes of densities >10 9 cm -3 which are free from solvent or matrix contamination demonstrate the suitability and potential of the source for studying ultrafast dynamics in the gas phase using fs laser pulses. Results obtained with phenylalanine show that through manipulation of fundamental femtosecond laser parameters (such as pulse length, intensity and wavelength), energy deposition within the molecule can be controlled to allow enhancement of parent ion production or generation of characteristic fragmentation patterns. In particular by reducing the pulse length to a timescale equivalent to the fastest vibrational periods in the molecule, we demonstrate how fragmentation of the molecule can be minimised whilst maintaining a high ionisation efficiency.

AB - Laser induced acoustic desorption (LIAD) has been used for the first time to study the parent ion production and fragmentation mechanisms of a biological molecule in an intense femtosecond (fs) laser field. The photoacoustic shock wave generated in the analyte substrate (thin Ta foil) has been simulated using the hydrodynamic HYADES code, and the full LIAD process has been experimentally characterised as a function of the desorption UV-laser pulse parameters. Observed neutral plumes of densities >10 9 cm -3 which are free from solvent or matrix contamination demonstrate the suitability and potential of the source for studying ultrafast dynamics in the gas phase using fs laser pulses. Results obtained with phenylalanine show that through manipulation of fundamental femtosecond laser parameters (such as pulse length, intensity and wavelength), energy deposition within the molecule can be controlled to allow enhancement of parent ion production or generation of characteristic fragmentation patterns. In particular by reducing the pulse length to a timescale equivalent to the fastest vibrational periods in the molecule, we demonstrate how fragmentation of the molecule can be minimised whilst maintaining a high ionisation efficiency.

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U2 - 10.1039/c2cp23840c

DO - 10.1039/c2cp23840c

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AN - SCOPUS:84861910368

SN - 1463-9076

VL - 14

SP - 6289

EP - 6297

JO - Physical Chemistry Chemical Physics

JF - Physical Chemistry Chemical Physics

IS - 18

ER -

LIAD-fs scheme for studies of ultrafast laser interactions with gas phase biomolecules

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